First detection of OXA-48-producing Klebsiella pneumoniae in community-acquired urinary tract infection in Algeria

Loucif, Lotfi; Chelaghma, Widad; Helis, Yassine; Sebaa, Farida; Baoune, Rayane Douniazed; Zaatout, Wafa; Rolain, Jean‐Marc

doi:10.1016/j.jgar.2017.12.017

Cited by 14 publications

(8 citation statements)

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“…However, since 2015, multiple countries have inter-regional spread and bla OXA-48 is endemic in Malta and Turkey [ 147 ]. Further afield, extensively drug resistant (XDR) strains co-harbouring bla NDM and bla OXA-48 have been identified in the Middle East [ 177, 178 ], and bla OXA-48 strains have emerged in Canada [ 173 ], Algeria [ 179 ] and Korea [ 180 ]. Shewanella spp.…”

Section: Cpementioning

confidence: 99%

Extended-spectrum β-lactamase-producing and carbapenemase-producing Enterobacteriaceae

Wilson

Török

2018

Microbial Genomics

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Antimicrobial resistance (AMR) is a global public-health emergency, which threatens the advances made by modern medical care over the past century. The World Health Organization has recently published a global priority list of antibiotic-resistant bacteria, which includes extended-spectrum β-lactamase-producing Enterobacteriaceae and carbapenemase-producing Enterobacteriaceae. In this review, we highlight the mechanisms of resistance and the genomic epidemiology of these organisms, and the impact of AMR.

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Section: Cpementioning

confidence: 99%

Extended-spectrum β-lactamase-producing and carbapenemase-producing Enterobacteriaceae

Wilson

Török

2018

Microbial Genomics

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“…Indeed, various studies on OXA-48-like-producing Enterobacteriaceae have been published in Algeria, involving clinical strains recovered from various hospitals located in different regions in Algeria including outbreaks [6] , [7] , from companion and wild animals, river water and from fresh vegetables [7] . More recently, the bla OXA-48 gene has also been detected in Algerian community [5] . The OXA-48-producing E. cloacae isolate identified in the current study was shown to belong to the sequence type 108.…”

Section: Discussionmentioning

confidence: 96%

“…Thus, carbapenems have become among the last-resort drugs in the treatment of severe infections caused by these bacteria. Unfortunately, widespread use of carbapenems has led to the emergence of carbapenem-resistant GNB [5] , [6] .…”

Section: Introductionmentioning

confidence: 99%

First detection of an OXA-48-producing Enterobacter cloacae isolate from currency coins in Algeria

Bendjama

Loucif

Chelaghma

et al. 2020

Journal of Global Antimicrobial Resistance

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Highlights First report of bla OXA-48 gene in enterobacterial strain isolated from coins. Coins as a reservoir of carbapenem-resistant Enterobacteriaceae. First detection of CTX-M-27-producing Raoultella ornithinolytica from money. First detection of CTX-M-14-producing E. coli from money.

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“…In this study, the sampled areas were located in environments with a high human population, close to hospitals and wastewater, known reservoirs of antibiotic-resistance genes, where the birds can access water and food that is contaminated with pharmaceutical products such as antibiotics. In this context and in the same city where our study was conducted, the first detection of the p bla OXA-48 gene was described in 2014 at Batna university hospital, then from migratory birds, community-acquired infection, currency, and more recently from hospital wastewater [ 20 , 21 , 42 , 43 , 44 ], suggesting that the detected genes in pigeon are related to their feeding mode in different locations including hospitals and wastewater or by contact with other birds such as migratory birds. From pigeons, only two studies have reported the detection of carbapenemase-producing Gram-negative bacteria worldwide.…”

Section: Discussionmentioning

confidence: 99%

Detection of blaOXA-48 and mcr-1 Genes in Escherichia coli Isolates from Pigeon (Columba livia) in Algeria

et al. 2022

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The emergence and spread of β-lactams and colistin-resistant Escherichia coli in birds deserve a special concern worldwide. This study aimed to investigate the presence of β-lactams and colistin-resistant Escherichia coli strains isolated from the faeces of urban and rural pigeons in Batna, Algeria, and to characterise their molecular traits of resistance. Between March and April 2019, a total of 276 faecal droppings samples were collected in Batna, Algeria. Samples were subjected to selective isolation of β-lactams and colistin-resistant Escherichia coli. The representative colonies were then identified using Matrix-Assisted Laser Desorption-Ionization Time-of-Flight Mass Spectrometry. Antimicrobial susceptibility testing was performed using the disc diffusion method. β-lactamases, as well as mcr genes, were screened for by PCR and confirmed by sequencing. Genetic relatedness of the mcr-positive E. coli strains was determined using multi-locus sequence typing analysis. Transferability features of carbapenemase genes were assessed by conjugation experiments. Overall, thirty-five E. coli isolates were obtained only from urban pigeon samples. All carbapenem-resistant isolates harboured the blaOXA-48 gene as the only carbapenemase gene detected (n = 11), while blaESBL genes were detected in eighteen isolates. Out of the thirty-five isolates, four E. coli isolates were positive for the mcr-1 gene. The obtained mcr-1 positive E. coli isolates belonged to four STs, including ST1485, ST224, ST46, and a new ST. This study is the first to report the isolation of E. coli strains carrying the mcr-1 gene from pigeon faeces in Algeria and also the first to report the detection of blaOXA-48-positive E. coli in pigeons. Close surveillance is, therefore, urgently needed to monitor the dissemination of blaOXA-48 and mcr-1 producing E. coli strains in wildlife.

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First detection of OXA-48-producing Klebsiella pneumoniae in community-acquired urinary tract infection in Algeria

Cited by 14 publications

References 3 publications

Extended-spectrum β-lactamase-producing and carbapenemase-producing Enterobacteriaceae

Extended-spectrum β-lactamase-producing and carbapenemase-producing Enterobacteriaceae

First detection of an OXA-48-producing Enterobacter cloacae isolate from currency coins in Algeria

Detection of blaOXA-48 and mcr-1 Genes in Escherichia coli Isolates from Pigeon (Columba livia) in Algeria

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