A Jupiter-family comet, 17P/Holmes, underwent outbursts in 1892 and 2007. In particular, the 2007 outburst is known as the greatest outburst over the past century. However, little is known about the activity before the outburst because it was unpredicted. In addition, the time evolution of the nuclear physical status has not been systematically studied. Here we study the activity of 17P/Holmes before and after the 2007 outburst through optical and mid-infrared observations. We found that the nucleus highly depleted its near-surface icy component before but became activated after the -3 -2007 outburst. Assuming a conventional 1-µm-sized grain model, we derived a surface fractional active area of 0.58% ± 0.14% before the outburst whereas it was enlarged by a factor of ∼50 after the 2007 outburst. We also found that large (≥1 mm) particles could be dominant in the dust tail observed around aphelion. Based on the size of the particles, the dust production rate was 170 kg s −1 at the heliocentric distance r h = 4.1 AU, suggesting that the nucleus still held active status around the aphelion passage. The nucleus color was similar to that of the dust particles and average for a Jupiter-family comet but different from most Kuiper Belt objects, implying that the color may be inherent to icy bodies in the solar system. On the basis of these results, we concluded that more than 76 m surface materials were blown off by the 2007 outburst.