First‐derivative synchronous spectrofluorimetric method for estimation of losartan potassium and atorvastatin in their pure forms and in tablets

Abstract

Losartan potassium (LOS) and atorvastatin (ATR) are used in combination for longterm treatment of stroke and for treatment of hypertension with high-level cholesterol. Both drugs were simultaneously determined and validated using a novel, easy, fast, and economical first-derivative synchronous fluorescence spectroscopic method. Methanol was used as the solvent for both drugs at a Δλ 80 nm and with a scanning rate of 600 nm/min. Peaks were determined as at 288.1 nm and 263.6 nm for LOS and ATR, respectively. The proposed method was validated according to International Conference on Harmonization guidelines and, subsequently, the developed method was applicable to the analysis of the two compounds in their different formulations without interference from each other. Amplitude-concentration plots were rectilinear over the concentration ranges 1.0-10.0 μg/ml and 0.5-5.0 μg/ml for LOS and ATR, respectively. Detection limits were found to be 0.096 μg/ml and 0.030 μg/ml and quantitation limits were 0.291 μg/ml and 0.093 μg/ml for LOS and ATR, respectively. The proposed method was successfully applied to the analysis of both compounds in synthetic mixtures and in laboratory-prepared tablets. These results were in accordance with the results acquired using the comparison method, high-performance liquid chromatography. K E Y W O R D Satorvastatin, losartan potassium, prepared tablets, synchronous fluorescence spectroscopy

Eco‐friendly simultaneous estimation of atenolol and losartan potassium in spiked human plasma via synchronous fluorescence with sustainability assessment

“…It is primarily used for the management of hypertension and diabetic nephropathy, also indicated for the reduction of stroke risk. It was determined alone or simultaneously with other drugs by various techniques including spectroscopic techniques [12][13][14][15][16][17][18][19], electrochemical methods [20,21], and chromatographic techniques [22,23].…”

Machine Learning-Assisted Synchronous Fluorescence Sensing Approach for Rapid and Simultaneous Quantification of Thiabendazole and Fuberidazole in Red Wine

“…Synchronous fluorescence spectrometry, a technique initially described by Lloyd [16] in 1971 to map fluorescence spectra in the presence of simultaneous scanning of both excitation and emission monochromators, has been widely utilized for the investigation of mixtures. The simultaneous fluorescence approach is used by a growing number of scientists for the determination of compounds in complicated matrices, and it may be combined with other techniques, such as derivative technique, to accomplish further spectral separations [17][18][19][20][21][22]. Among these, the constant-energy synchronous fluorescence approach utilized in this work can effectively simplify the spectra, narrow the spectral band, and eliminate the influence of scattered light by selecting an appropriate constant-energy difference, making it advantageous for the detection of mixtures.…”