First-Derivative Spectrophotometric Determination of a Mixture of Pirbuterol Hydrochloride and Butorphanol Tartrate

Mohamed, M. E.

doi:10.1080/00032718608066304

Cited by 24 publications

(5 citation statements)

References 20 publications

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“…Spectrophotometry may be helpful in the analysis of simple mixtures by direct determination at the wavelength of maximum absorption (λ max). Some methods employed spectral manipulation for the determination of overlapped spectral data in binary mixtures such as derivative [1], [2], derivative ratio [3][4][5][6], dual-wavelength [7][8][9], H-point standard additions [10][11][12] and ratio difference [13][14][15] methods. However, only a few conventional methods based on simple mathematical manipulation were able to introduce solutions for the analysis of complex ternary mixtures.…”

Section: Introductionmentioning

confidence: 99%

Novel spectrophotometric method for the analysis of ternary mixtures

Saad

Hamdy

Merey

et al. 2022

ERU Research Journal

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Though simple, rugged and reliable classical spectrophotometric methods have not proven adequate selectivity in the analysis of ternary mixtures with overlapped spectral data. Recently emerging methods incorporates several steps of mathematical manipulations to resolve the spectral overlap. The work introduces the novel H-point derivative ratio method (HDR) and compares its performance with the recently developed dual wavelength in ratio spectrum (DWRS). The resolution power of the H-point standard additions and the derivative ratio methods-resolve binary mixtures-merge to engender the HDR for the analysis of ternary mixtures. HDR and DWRS methods were applied to resolve the severely overlapped spectral data of the ternary mixture: caffeine, propyphenazone and paracetamol. The latter is the first line antipyretic in COVID19 symptomatic relief. One-way ANOVA statistical analysis proved the absence of significant differences between the analytical results of HDR, DWRS and the reported method. Validation parameters were assessed according to the ICH guidelines. The developed HDR method expressed sensitivity and selectivity potentials for routine analysis of the analytes in their pure powder form, ternary mixture and pharmaceutical formulation without prior extraction or interference from additives.Keywords: H-point derivative ratio method; Dual wavelength in ratio spectrum method; caffeine; propyphenazone; paracetamol.a Accuracy (mean of percentage recoveries ± SD) assessed using a minimum of nine determinations over a minimum of three concentration levels covering the specified range.b Specificity (mean of percentage recoveries ± SD) of recovery percentage data of the laboratory prepared mixtures. c The intraday (n = 3), RSD of three concentrations repeated three times within the day. d The interday (n = 3), RSD of three concentrations repeated three times in three successive days.

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Section: Introductionmentioning

confidence: 99%

Novel spectrophotometric method for the analysis of ternary mixtures

Saad

Hamdy

Merey

et al. 2022

ERU Research Journal

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“…As an alternative method, Vierordt's method (20,21) was used for simultaneous determination of these compounds in laboratory mixtures and pharmaceutical formulations. 84 ERK AND GÖ NÜ LLÜ…”

Section: Introductionmentioning

confidence: 99%

Resolution of Two-Component Mixtures in Pharmaceutical Formulations Containing Phenazopyridine Hydrochloride by Ratio Spectra Derivative Spectrophotometry

Erk

Gönüllü

2002

Analytical Letters

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The ratio spectra derivative spectrophotometry was applied for the simultaneous determination of phenazopyridine hydrochloride with sulfisoxazole or ampicillin trihydrate in binary mixtures. The procedures do not require any separation step. The analytical signals were measured at 252.3 and 276.6 nm in the phenazopyridine hydrochloride with sulfisoxazole in mixture, 324.9 and 283.6 nm in the phenazopyridine hydrochloride with ampicillin trihydrate in mixture for phenazopyridine hydrochloride and its co-existing compounds, 83 ORDER REPRINTS respectively, in the first derivative of the ratio spectra of the mixture solutions in methanol. Calibration graphs were established for 2.0-18.0 mg ml À1 phenazopyridine hydrochloride and 2.0-32.0 mg ml À1 sulfisoxazole in phenazopyridine hydrochloride-sulfisoxazole mixture, and for 2.0-18.0 mg ml À1 phenazopyridine hydrochloride and 4.0-32.0 mg ml À1 ampicillin trihydrate in binary mixture. The method was successfully applied to the pharmaceutical formulations containing the above-mentioned drug combinations without any interference by the excipients. Vierordt's method was also developed for a comparison method.

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“…Many researcher have used Vierordt's and modified Vierordt's methods (17)(18)(19) , derivative spectrophotometry (20)(21)(22)(23) and ratio spectra derivative spectrophotometry (24)(25)(26)(27)(28) for the analysis of pharmaceutical preparations containing drug mixtures. Also, we used these methods for the analysis of multicomponent formulations (29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Atropine Sulfate and Morphine Hydrochloride in Their Binary Mixture Using Spectrophotomeric Methods : İki̇li̇ Karişiminda Atropi̇n Sulfat Ve Morfi̇n Hi̇droklorürün Spektrofo

Dinç¹,

Onur²

2001

Ankara Universitesi Eczacilik Fakultesi Dergisi

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Ankara Üniversitesi Eczacılık Fakültesi Dergisi farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayın ortamıdır. Bu dergi yılda 4 sayı yayınlanır. Yayımlanan yazıların sorumluluğu yazar(lar)ına aittir. Dergiye gönderilen makalelerin daha önce tamamen veya kısmen başka bir yerde yayınlanmamış veya yayını için başka bir yere başvuruda bulunulmamış olması gereklidir. Makaleler derginin arka sayfalarında yer alan yazım kurallarına uymalıdır.Bu dergi, Chemical Abstracts (CA), Excerpta Medica Database (EMBASE),Medicinal Aromatic Plants Abstracts (MAPA) ve Türk Tıp Dizini 'nde indekslenmektedir.

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First-Derivative Spectrophotometric Determination of a Mixture of Pirbuterol Hydrochloride and Butorphanol Tartrate

Cited by 24 publications

References 20 publications

Novel spectrophotometric method for the analysis of ternary mixtures

Novel spectrophotometric method for the analysis of ternary mixtures

Resolution of Two-Component Mixtures in Pharmaceutical Formulations Containing Phenazopyridine Hydrochloride by Ratio Spectra Derivative Spectrophotometry

Simultaneous Determination of Atropine Sulfate and Morphine Hydrochloride in Their Binary Mixture Using Spectrophotomeric Methods : İki̇li̇ Karişiminda Atropi̇n Sulfat Ve Morfi̇n Hi̇droklorürün Spektrofo

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