First demonstration of the neuroepithelial cells and their chemical code in the accessory respiratory organ and the gill of the sharptooth catfish, <i>Clarias gariepinus</i>: A preliminary study

Zaccone, Giacomo; Maina, John N.; Germanà, Antonino; Montalbano, Giuseppe; Capillo, Gioele; Aragona, Luisa; Kuciel, Michał; Lauriano, Eugenia Rita; Icardo, José M.

doi:10.1111/azo.12242

Cited by 18 publications

(13 citation statements)

References 26 publications

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“…Teleosts have a respiratory system that allows for gas exchange of dissolved oxygen absorption and carbon dioxide emission between their body membrane and water (Fernandes, 2016 ). This physiological metabolism is observed in diverse internal organs such as gills (Lefevre et al 2011 ; Blank and Burggren 2014 ), gastrointestinal surface (Grosell et al 2010 ), swim bladder (Fernandes et al 2012 ), branchial chamber (Sundin et al 1999 ), labyrinthine organ (Zaccone et al 2019 ), and skin (Glover et al 2013 ). Among them, the skin is responsible for 5 to 30% of oxygen absorption in underwater teleosts (Graham 1997 ) that inhabit shallow and stagnant water with lower oxygen levels (Wright 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Histology and morphometry of the skin of the trident goby Tridentiger brevispinis (Perciformes, Gobiidae)

Kim

2022

Appl. Microsc.

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The Korean trident goby, Tridentiger brevispinis, lives in adverse habitats that can easily become hypoxic due to low precipitation, regional dry periods, and high amounts of solar radiation. Histological and morphometric studies revealed the goby’s specialized skin (35.4–150.0 μm in thickness), consisting of an epidermis and dermis. The thicker epidermis comprises an outermost surface layer (having taste buds, stratified flattened cells, mucous cells, pigment cells, and stratified polygonal cells), middle layer (having stratified polygonal cells), and stratum germinativum (stratified columnar cells). In particular, the dermis has scales, well-developed vascularization, and a few blood capillaries just above the basement membrane, and a reduced diffusion distance was present in the lateral body. Consequently, adaptations such as thicker epidermis, well-developed vascularization, few blood capillaries, and a reduced diffusion distance may provide cutaneous respiration for survival in poorly oxygenated water during the periodic dry season.

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Section: Introductionmentioning

confidence: 99%

Histology and morphometry of the skin of the trident goby Tridentiger brevispinis (Perciformes, Gobiidae)

Kim

2022

Appl. Microsc.

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“…Neurons capable of producing nitric oxide (NO) were detected by the presence of nNOS (monoclonal anti-nNOS and polyclonal anti-nNOS). The characterization, specificity and reliability of the antibodies directed against choline acetyltransferase (ChAT) and nNOS, and their application in morphological studies of the intracardiac ganglia containing a heterogeneous population of neurons [ 46 ], the zebrafish enteric nervous system [ 44 ] and the neuroepithelial cell system of the fish gill [ 41 , 47 ], have been previously reported.…”

Section: Methodsmentioning

confidence: 99%

Structural Identification of the Pacemaker Cells and Expression of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels in the Heart of the Wild Atlantic Cod, Gadus morhua (Linnaeus, 1758)

Capillo

Lauriano

Icardo

et al. 2021

IJMS

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Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are proteins that contain highly conserved functional domains and sequence motifs that are correlated with their unique biophysical activities, to regulate cardiac pacemaker activity and synaptic transmission. These pacemaker proteins have been studied in mammalian species, but little is known now about their heart distribution in lower vertebrates and c-AMP modulation. Here, we characterized the pacemaker system in the heart of the wild Atlantic cod (Gadus morhua), with respect to primary pacemaker molecular markers. Special focus is given to the structural, ultrastructural and molecular characterization of the pacemaker domain, through the expression of HCN channel genes and the immunohistochemistry of HCN isoforms, including the location of intracardiac neurons that are adjacent to the sinoatrial region of the heart. Similarly to zebrafish and mammals, these neurons are immunoreactive to ChAT, VAChT and nNOS. It has been shown that cardiac pacemaking can be modulated by sympathetic and parasympathetic pathways, and the existence of intracardiac neurons projecting back to the central nervous system provide a plausible link between them.

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“…In mammals, the EGFR plays an important role in lung maturation; EGFR deficiency results in a mild respiratory distress syndrome and delayed lung maturation (Miettinen et al 1997 ). Other essential elements include secretory neuroepithelial-like cells (NECs), putative chemoreceptors (Zaccone et al 2017 , 2018 , 2019 , 2020 , Capillo et al 2021 ; Lauriano et al 2021 ), which are probably responsible for the control of proliferation of AT1 cells (Fig. 3 ) in the digestive tract in the GBF during hypoxia (Satora et al 2020b ).…”

Section: Promising Natural Modelmentioning

confidence: 99%

Quest for breathing: proliferation of alveolar type 1 cells

Satora

Gawlikowski

Tański

et al. 2022

Histochem Cell Biol

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There is much evidence that the vertebrate lung originated from a progenitor structure which was present in bony fish. However, critical basic elements for the evolution of breathing in tetrapods, such as the central rhythm generator sensitive to CO2/pH and the pulmonary surfactant, were present in the lungless primitive vertebrate. This suggests that the evolution of air breathing in all vertebrates may have evolved through exaptations. It appears that the capability for proliferation of alveolar type 1 (AT1) cells is the “critical factor” which rendered possible the most radical subsequent innovation—the possibility of air breathing. “Epithelial remodeling,” which consists in proliferation of alveolar cells—the structural basis for gas diffusion—observed in the alimentary tract of the gut-breathing fishes (GBF) has great potential for application in biomedical research. Such a process probably led to the gradual evolutionary development of lungs in terrestrial vertebrates. Research on the cellular and molecular mechanisms controlling proliferation of squamous epithelial cells in the GBF should contribute to explaining the regeneration-associated phenomena that occur in mammal lungs, and especially to the understanding of signal pathways which govern the process.

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First demonstration of the neuroepithelial cells and their chemical code in the accessory respiratory organ and the gill of the sharptooth catfish, Clarias gariepinus: A preliminary study

Cited by 18 publications

References 26 publications

Histology and morphometry of the skin of the trident goby Tridentiger brevispinis (Perciformes, Gobiidae)

Histology and morphometry of the skin of the trident goby Tridentiger brevispinis (Perciformes, Gobiidae)

Structural Identification of the Pacemaker Cells and Expression of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels in the Heart of the Wild Atlantic Cod, Gadus morhua (Linnaeus, 1758)

Quest for breathing: proliferation of alveolar type 1 cells

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