First-degree Relatives Are Frequently Affected in Coeliac Disease and Dermatitis Herpetiformis

Hervonen, Kaisa; Hakanen, M; Kaukinen, Katri; Collin, Pekka; Reunala, Timo

doi:10.1080/003655202753387356

Cited by 54 publications

(43 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many studies have found that the prevalence of CD is greater in siblings than in other first-degree relatives of CD patients [16,17,18,19,20], but the reported prevalence rates vary depending on case selection, diagnostic criteria and study design (although they are usually lower than that found by us). Similar results have been reported by Bonamico et al [21] in Italy who found CD in 19/104 siblings (18%), although they may have missed the diagnosis in 6 serologically positive siblings who did not undergo endoscopy, and so the actual prevalence may have been 24%.…”

Section: Discussioncontrasting

confidence: 46%

Silent Celiac Disease Is Frequent in the Siblings of Newly Diagnosed Celiac Patients

et al. 2007

View full text Add to dashboard Cite

Background/Aims: Celiac disease is caused by environmental and genetic factors, and the relatives of celiac patients are at higher risk of developing celiac disease than the general population. This prospective study evaluates the prevalence of celiac disease in the asymptomatic siblings of celiac patients. Methods: Forty-eight siblings (22 males; mean age 13 years) of 39 celiac children (20 males; mean age 4 years), and 120 siblings (55 males; mean age 33 years) of 55 adult celiac patients (12 males; mean age 31 years) were serologically screened for celiac disease. Positive cases were considered for endoscopic duodenal biopsies. Results: Forty of the 168 asymptomatic siblings (23.8%) were affected by celiac disease. There were no differences between the index cases with and without affected siblings in terms of age at diagnosis, symptoms at onset, order of birth, associated disorders or other affected relatives. The male siblings of pediatric patients were affected in 40.9% of cases and female siblings in 26.9%; the corresponding figures for adults were 16.4 and 23.1%. Conclusions: Silent celiac disease is 24–48 times more frequent in the siblings of celiac patients than in the general population. No predictive factors for sibling involvement were found. Adult females seem to tolerate gluten less than adult males.

show abstract

Section: Discussioncontrasting

confidence: 46%

Silent Celiac Disease Is Frequent in the Siblings of Newly Diagnosed Celiac Patients

et al. 2007

View full text Add to dashboard Cite

show abstract

“…In children who were diagnosed with CD, the average number of samples studied, with standard deviation (s.d.) and range in parenthesis, was 11·8 (Ϯ3·9; [7][8][9][10][11][12][13][14][15][16][17][18][19], and for the children with transient or fluctuating values, 14·1 (Ϯ4·0; [7][8][9][10][11][12][13][14][15][16][17][18][19][20]. At the time of the diagnosis of CD, children were of a mean age of 4·4 (Ϯ1·3; 3·1-6·7) years.…”

Section: Subjectsmentioning

confidence: 99%

Affinity maturation of immunoglobulin A anti-tissue transglutaminase autoantibodies during development of coeliac disease

Westerlund

Ankelo

Simell

et al. 2007

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SummaryCoeliac disease (CD) is an immune-mediated enteropathy triggered by ingestion of wheat gluten and related cereals in genetically predisposed individuals. Circulating immunoglobulin A (IgA) class autoantibodies against tissue transglutaminase (IgA-TGA) are highly specific and sensitive serological markers for CD, which is ultimately confirmed by duodenal biopsy. Although CD is considered a life-long disorder, transient or fluctuating IgA-TGA seropositivity has been observed in asymptomatic individuals on a glutencontaining diet. We set out to explore possible differences in the maturation of IgA-TGA avidity between individuals progressing to CD and subjects remaining healthy despite occasional expression of autoantibodies. We developed a time-resolved fluorometric IgA-TGA assay based on human recombinant tissue transglutaminase (tTG), and further modified the method to also measure urea-dependent avidity of the autoantibodies. We measured the autoantibody titres and avidities of sequential serum samples from 10 children developing CD and 10 children presenting transient or fluctuating autoantibodies. Both the initial titres at seroconversion and peak values of transient/fluctuating IgA-TGA were significantly lower than corresponding autoantibody titres in samples drawn from individuals with progressing CD (P = 0·004 and P = 0·0002, respectively). However, there were no statistically significant differences in the initial or peak avidity index values between the two groups of children. The avidity index values increased during the follow-up period (P = 0·013 for both groups) with no significant difference in the rate of avidity maturation between children with transient/fluctuating IgA-TGA and children developing CD. According to our results, high autoantibody titres have a higher predictive value than avidity maturation of TGA-IgA in screening for CD.

show abstract

“…Importantly, NHL occurrence seems to be reduced in DH patients whose diagnosis was made over the recent years (Viljamaa et al, 2006) maybe due to a less adherence of patients to a gluten-free diet in the past, not considered as essential as nowadays in DH. First-degree relatives of patients with DH or CD have an higher risk of developing a gluten-sensitive enteropathy (Hervonen et al, 2002). This is not true for lymphoma risk, as demonstrated in a large series of patients with DH and their first-degree relatives, where three lymphoma cases (0.2%) were diagnosed among 1.825 first-degree relatives, compared with the prevalence in the general population of 0.1%.…”

Section: Dermatitis Herpetiformismentioning

confidence: 96%

Autoimmune Disorders and Lymphomas

Dolcetti¹,

Ponzoni²,

Mappa³

et al. 2011

Autoimmune Disorders - Pathogenetic Aspects

View full text Add to dashboard Cite

First-degree Relatives Are Frequently Affected in Coeliac Disease and Dermatitis Herpetiformis

Cited by 54 publications

References 17 publications

Silent Celiac Disease Is Frequent in the Siblings of Newly Diagnosed Celiac Patients

Silent Celiac Disease Is Frequent in the Siblings of Newly Diagnosed Celiac Patients

Affinity maturation of immunoglobulin A anti-tissue transglutaminase autoantibodies during development of coeliac disease

Autoimmune Disorders and Lymphomas

Contact Info

Product

Resources

About