First day postoperative values of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and C-reactive protein as complication predictors following gastric oncologic surgery

López, David; Acosta-Mérida, María Asunción; Casimiro-Pérez, J.A.; Silvestre-Rodríguez, José; Marchena‐Gómez, Joaquín

doi:10.1016/j.rgmxen.2021.11.003

Cited by 5 publications

(4 citation statements)

References 24 publications

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“…Pretreatment staging evaluation included physical examination, endoscopy, contrast-enhanced computed tomography (CT) scans from the neck to the upper abdomen, positron emission tomography-computed tomography (PET-CT) scans, and endoscopic ultrasound. Tumor node metastasis stage was determined according to the 7th AJCC staging system (Edge C.C., Fritz AG, Greene FL, Trotti A, C.C., Fritz AG, Greene FL, Trotti A 2010 ). The study was approved by the Institutional Review Board of Chang Gung Memorial Hospital.…”

Section: Methodsmentioning

confidence: 99%

Preoperative neutrophil–to–lymphocyte ratio after chemoradiotherapy for esophageal squamous cell carcinoma associates with postoperative pulmonary complications following radical esophagectomy

Lo,

Lu,

Wang

et al. 2024

Perioper Med

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Objectives Esophagectomy after chemoradiotherapy is associated with an increased risk of surgical complications. The significance of preoperative neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio after chemoradiotherapy in predicting pulmonary complications following radical esophagectomy in esophageal squamous cell carcinoma patients receiving preoperative chemoradiotherapy remains unknown. We aimed to investigate the utility of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in predicting the pulmonary complications of esophagectomy after preoperative chemoradiotherapy. Methods We retrospectively reviewed 111 consecutive patients with stage III esophageal squamous cell carcinoma who received preoperative chemoradiotherapy followed by esophagectomy between January 2009 and December 2017. Laboratory data were collected before the operation and surgical outcomes and complications were recorded. We calculated neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio and correlated them with the clinical parameters, postoperative complications, overall survival, and disease-free survival. Results Postoperative complications were observed in 75 (68%) patients, including 32 (29%) with pulmonary complications. The preoperative neutrophil-to-lymphocyte ratio of ≥ 3 (P = 0.008), clinical T4 classification (P = 0.007), and advanced stage IIIC (P = 0.012) were significantly associated with pulmonary complications. Pulmonary complication rates were 15% and 38% in patients with preoperative neutrophil-to-lymphocyte ratio of < 3 and ≥ 3, respectively. Preoperative neutrophil-to-lymphocyte ratio was not associated with the oncological stratification such as pathological T classification, pathological N classification, and pathological AJCC stage. The 3-year overall survival rates were 70% and 34% in patients with preoperative neutrophil-to-lymphocyte ratio of < 3 and ≥ 3, respectively (P = 0.0026). The 3-year disease-free survival rates were 57% and 29% in patients with preoperative neutrophil-to-lymphocyte ratio of < 3 and ≥ 3, respectively (P = 0.0055). The preoperative neutrophil-to-lymphocyte ratio of ≥ 3 was independently associated with more pulmonary complications, inferior overall survival, and worse disease-free survival. Conclusions Elevated preoperative neutrophil-to-lymphocyte ratio after chemoradiotherapy is independently associated with higher pulmonary complication rate following radical esophagectomy and poor prognosis in patients with esophageal squamous cell carcinoma receiving preoperative chemoradiotherapy. Preoperative neutrophil-to-lymphocyte ratio is routinely available in clinical practice and our findings suggest it can be used as a predictor for pulmonary complications after esophagectomy in patients with esophageal squamous cell carcinoma receiving preoperative chemoradiotherapy.

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Section: Methodsmentioning

confidence: 99%

Preoperative neutrophil–to–lymphocyte ratio after chemoradiotherapy for esophageal squamous cell carcinoma associates with postoperative pulmonary complications following radical esophagectomy

Lo,

Lu,

Wang

et al. 2024

Perioper Med

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“…The preoperative nutritional status of patients re ects their ability to resist infection and heal tissues. The serum albumin (ALB) level, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and C-reactive protein-to-albumin ratio (CAR) are commonly used as predictors of postoperative complications in gastrointestinal cancer patients [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Predictive Value of Preoperative Serum Prealbumin Levels for Postoperative Complications and Survival Outcomes in Patients Undergoing Surgery for Malignant Bowel Obstruction: A Comprehensive Analysis

Weng,

Lai,

Wang

et al. 2024

Preprint

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Background Malignant bowel obstruction (MBO) is a common complication in advanced abdominal cancer patients, characterized by a high overall incidence and poor prognosis. Postoperative complications are particularly frequent, with a low postoperative survival rate. The preoperative nutritional status of patients, especially the prealbumin (PA) levels, is significantly correlated with postoperative issues and long-term prognosis. This study aimed to assess the predictive value of the preoperative prealbumin (PA) concentration for postoperative complications and long-term survival in patients with malignant bowel obstruction (MBO). Methods Single-factor and multifactor logistic regression analyses were performed to identify independent risk factors for severe complications and infectious complications. Moreover, univariate and multivariate stratified Cox regression analyses were employed to identify independent risk factors for overall survival (OS), and corresponding nomograms were created. Kaplan-Meier survival curves were generated for grouped data with statistically significant differences. The area under the curve (AUC) was compared to assess the testing efficacy of different nutritional indicators for severe postoperative complications. Results There was a statistically significant difference in the comparison of overall complications and infectious complications between the two groups for different Clavien-Dindo (CD) grades (p < 0.001). Specifically, the incidence of complications with CD grade ≥ 3 in the superlow PA group was higher (p<0.001), and a gradual increase in the severity of overall and postoperative infectious complications was observed with decreasing PA levels (p < 0.001). PA (p < 0.001) and intestinal stent placement (p = 0.015) were identified as independent influencing factors for early postoperative severe complications (CD grade ≥ 3), while PA was identified as an independent influencing factor for postoperative infectious complications (p < 0.001). Cox regression analysis stratified by TNM stage revealed that age, sex, surgical method, and postsurgical chemotherapy were independent predictors of OS. Compared to indicators such as the FPR and AFP, PA demonstrated the highest testing efficiency (AUC = 0.888). Conclusion Preoperative PA has significant predictive value for early postoperative complications and overall survival in patients with MBO, providing new insights into perioperative nutritional intervention and surgical approach selection for these patients.

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“…9 Inflammation is associated with changes in peripheral blood, especially in neutrophil lymphocyte cells, and the severity of inflammation can be determined by the neutrophil/lymphocyte ratio (NLR). 9 10 It has been reported that preoperative NLR is useful in detecting patients with high complication rates in the early postoperative period. 11 For example, the preoperative NLR was found to be higher in pediatric patients with complicated appendicitis than in those with simple appendicitis.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Preoperative and Postoperative Neutrophil/Lymphocyte Ratio in Predicting Mortality in Neonates with Intestinal Atresia

Öztaş,

Dursun

2024

J Pediatr Infect Dis

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Objective Congenital intestinal atresia is one of the most common surgical pathologies in the neonatal period. This study aimed to compare the efficacy of preoperative neutrophil/lymphocyte ratio (NLR) and postoperative NLR in predicting early mortality in neonates with intestinal atresia. Methods The data of 38 newborns with intestinal atresia operated on in our hospital between January 2016 and March 2023 were retrospectively analyzed. Patients' gestational age, gender, birth weight, other congenital anomalies, operative findings, length of hospital stay, sepsis, and mortality rates were recorded. NLR was calculated by analyzing preoperative and postoperative day 1 complete blood tests. Results Of the patients included in the study, 60.5% were male and 39.5% were female. The median birth weight was 2,468 g (600–3,800 g), and the median gestational age was 36 weeks (28–40 weeks). Gender, number of areas of atresia in the gut, and development of sepsis were not associated with mortality. Mortality was observed at a lower rate in duodenal atresia when compared with the other types of atresia (p < 0.05). The mortality was higher in patients with prematurity, low birth weight, long duration of mechanical ventilation, and severe congenital anomalies (p < 0.05). Preoperative lymphocyte and neutrophil counts were not found to be predictive of mortality. The mortality rate increased as the postoperative lymphocyte count decreased and as the neutrophil count increased (p < 0.05). The preoperative and postoperative NLR was not useful in predicting mortality, the development of sepsis, or the need for reoperation. Conclusion It is possible to predict early mortality in newborns with intestinal atresia who underwent surgery with neutrophil and lymphocyte counts on the first day after surgery. However, early NLR is not useful in predicting prognosis after surgery in newborns.

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First day postoperative values of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and C-reactive protein as complication predictors following gastric oncologic surgery

Cited by 5 publications

References 24 publications

Preoperative neutrophil–to–lymphocyte ratio after chemoradiotherapy for esophageal squamous cell carcinoma associates with postoperative pulmonary complications following radical esophagectomy

Preoperative neutrophil–to–lymphocyte ratio after chemoradiotherapy for esophageal squamous cell carcinoma associates with postoperative pulmonary complications following radical esophagectomy

Predictive Value of Preoperative Serum Prealbumin Levels for Postoperative Complications and Survival Outcomes in Patients Undergoing Surgery for Malignant Bowel Obstruction: A Comprehensive Analysis

Comparison of Preoperative and Postoperative Neutrophil/Lymphocyte Ratio in Predicting Mortality in Neonates with Intestinal Atresia

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