First data from a population based cancer registry in Ethiopia

Timotewos, Genebo; Solomon, Asmare; Assefa, Mathewos; Addissie, Adamu; Bogale, Solomon; Wondemagegnehu, Tigeneh; Abraha, Aynalem; Ayalnesh, Bekele; Dagnechew, Hailemariam; Bireda, Wondatir; Kroeber, Eric Sven; Mikolajczyk, Rafael; Bray, Freddie; Jemal, Ahmedin; Kantelhardt, Eva Johanna

doi:10.1016/j.canep.2018.01.008

Cited by 66 publications

(59 citation statements)

References 24 publications

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“…Breast cancer is the most commonly diagnosed cancer among women in Ethiopia, as in other parts of Africa 1–4. In Addis Ababa, the capital city of Ethiopia, breast cancer accounts for one-third of all female cancers 1.…”

Section: Introductionmentioning

confidence: 99%

Time intervals experienced between first symptom recognition and pathologic diagnosis of breast cancer in Addis Ababa, Ethiopia: a cross-sectional study

et al. 2019

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ObjectivesThis study aimed to estimate the magnitude of patient and diagnostic delays and associated factors among women with breast cancer in Addis Ababa.DesignThis is a cross-sectional study.Settings and participantsAll women newly diagnosed with breast cancer in seven major healthcare facilities in Addis Ababa (n=441) were included in the study.Main outcomes and measuresPatient interval (time from recognition of first symptom to medical consultation) and diagnostic interval (time from first consultation to diagnosis). Patient intervals >90 days and diagnostic intervals >30 days were considered delays, and associated factors were determined using multivariable Poisson regressions with robust variance.ResultsThirty-six percent (95% CI [31.1%, 40.3%]) of the patients had patient intervals of >90 days, and 69% (95% CI [64.6%, 73.3%]) of the patients had diagnostic intervals of >30 days. Diagnostic interval exceeded 1 year for 18% of patients. Ninety-five percent of the patients detected the first symptoms of breast cancer by themselves, with breast lump (78.0%) as the most common first symptom. Only 8.0% were concerned about cancer initially, with most attributing their symptoms to other factors. In the multivariable analysis, using traditional medicine before consultation was significantly associated with increased prevalence of patient delay (adjusted prevalence ratio (PR) = 2.13, 95% CI [1.68, 2.71]). First consultation at health centres (adjusted PR = 1.19, 95% CI [1.02, 1.39]) and visiting ≥4 facilities (adjusted PR = 1.24, 95% CI [1.10, 1.40]) were associated with higher prevalence of diagnostic delay. However, progression of symptoms before consultation (adjusted PR = 0.73, 95% CI [0.60, 0.90]) was associated with decreased prevalence of diagnostic delay.ConclusionsPatients with breast cancer in Addis Ababa have prolonged patient and diagnostic intervals. These underscore the need for public health programme to increase knowledge about breast cancer symptoms and the importance of early presentation and early diagnosis among the general public and healthcare providers.

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Section: Introductionmentioning

confidence: 99%

Time intervals experienced between first symptom recognition and pathologic diagnosis of breast cancer in Addis Ababa, Ethiopia: a cross-sectional study

et al. 2019

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“…The rising burden of ovarian tumors in Ethiopia is prospectively captured in a population‐based cancer registry of Addis Ababa, Ethiopia . The Addis Ababa City Cancer Registry (AACCR) registered patients reported from Addis Ababa health facilities with histological verification or strong clinical evidence from 19 centers in town, including pathology centers, oncology clinics, the main referral hospitals, and diagnostic facilities.…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics and Survival of Patients with Malignant Ovarian Tumors in Addis Ababa, Ethiopia

et al. 2019

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Background Ovarian cancer is the third leading cause of cancer death among women in Ethiopia, with about 2,550 diagnosed cases and 2,000 deaths each year. The incidence and mortality rates of this disease have been increasing in Ethiopia and other parts of sub‐Saharan Africa over the past decades because of changing lifestyle and reproductive factors. In this study, we describe the clinical characteristics, treatment patterns, and survival of patients with ovarian cancer in Ethiopia. Materials and Methods This retrospective cohort study included 485 patients diagnosed between January 2009 and October 2015 at Addis Ababa University Hospital, Zewditu Memorial Hospital, or registered in the Addis Ababa population‐based cancer registry. Follow‐up data were obtained via telephone. Primary endpoint was all‐cause mortality. Results The median age was 46 years (range, 11–95). The estimated 1‐ and 2‐year overall survival rates were 78% (95% confidence interval [CI] 0.741–0.82.5) and 59% (95% CI, 0.538–0.646), respectively. Of those patients with result available (n = 423), 73.0% had epithelial cancers. Almost half were classified as Federation of Gynecology and Oncology stage III or IV (48.2%; stage available n = 201) resulting in worse outcomes (hazard ratio [HR], 2.91 [CI 0.67–12.64] and 3.03 [0.69–15.79], respectively). Four out of five patients received some form of surgery (82%), three out of five received platinum‐containing chemotherapy. Patients with residual tumor after surgery (n = 83) showed worse survival outcome (HR, 2.23; 95% CI 1.08–4.49). Conclusion Our study revealed substantial treatment gaps with respect to surgery and adequate chemotherapy. Higher stage, residual tumor and lack of chemotherapy impaired the outcome. Access to higher standards of ovarian cancer treatment is urgently needed in Ethiopia. Implications for Practice Ovarian cancer is often a fatal disease in high resource settings; now it is also becoming important in Ethiopia. This study included 485 women with malignant ovarian tumors treated in Addis Ababa who had a mean age of only 46 years because of the young population structure. Three quarters had the typical epithelial cancer, with half presenting with advanced stage III and IV. Improved oncologic surgery and sufficient chemotherapy could possibly improve their outcome. The relatively high proportion of women with nonepithelial cancer need adequate treatment options to have good prognosis.

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“…Breast cancer becomes incurable due to late medical presentation, lack of awareness, limited medical resources, and hospitals. Especially, the symptoms of breast cancer have some strong traditional beliefs that delay biomedical care (Timotewos, 2018). Because of confined access to well-timed and popular treatments, breast cancer survival tends to be poor in most of the Ethiopian regions.…”

Section: In Centralmentioning

confidence: 99%

Risk Factors Affecting Survival Time to First Recurrence of Breast Cancer Patients: The Case of South West Ethiopia

Bacha

Jabir

Tesfay³

et al. 2020

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Background: Among the cancers, next to cervical cancer, in Ethiopia, breast cancer is the second common cancer health problem for women. This article aimed to identify the potential risk factors affecting of time-to-first-recurrence of breast cancer patients in southwest Ethiopia: Jimma Medical Center, Bedelle hospital, Mizan-Aman hospital, and Mettu hospital and Karl hospital. Methods: The data were taken from the patient’s medical record that registered from January 2012 to January 2019. The study considered a sample size of 642 breast cancer patients. Different non-parametric and parametric shared frailty survival models employed. Results: Out of 642 breast cancer patients, about 447 (69.6 %) recovered/cured of the disease. The median cure time from breast cancer found 13 months. The lognormal parametric shared frailty survival model predicted that treatment, stage of breast cancer, smoking habit, and marital status significantly affects the time to the first recurrence of breast cancer. Conclusion: Treatment, stages of breast cancer, and marital status were improved while smoking habits worsen the time to first cure of breast cancer. To mitigate breast cancer diseases awareness should be given for the community on identified factors

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First data from a population based cancer registry in Ethiopia

Cited by 66 publications

References 24 publications

Time intervals experienced between first symptom recognition and pathologic diagnosis of breast cancer in Addis Ababa, Ethiopia: a cross-sectional study

Time intervals experienced between first symptom recognition and pathologic diagnosis of breast cancer in Addis Ababa, Ethiopia: a cross-sectional study

Clinical Characteristics and Survival of Patients with Malignant Ovarian Tumors in Addis Ababa, Ethiopia

Risk Factors Affecting Survival Time to First Recurrence of Breast Cancer Patients: The Case of South West Ethiopia

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