First copper(II)-cyclophosphato complex with macrocyclic N-donor ligand: Single crystal structure elucidation with Hirshfeld surface analysis, optical, electrochemical and antioxidant properties

Hemissi, Hanène; Fezai, Ramzi; Mezni, Ali; Besbes-Hentati, Salma; Rzaigui, M.

doi:10.1016/j.jssc.2018.04.004

Cited by 6 publications

(3 citation statements)

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“…However, the results of the inhibitory activity of the ABTS •+ and DPPH • radicals showed a great difference. In general, some authors report lower anti-free-radical activity on the ABTS •+ radical in pure compounds. , …”

Section: Resultsmentioning

confidence: 98%

“…In general, some authors report lower antifree-radical activity on the ABTS •+ radical in pure compounds. 54,55 Tetrandrine and its derivatives MAnT and MAcT are capable, at physiological conditions, in which their protonated dicationic forms predominate, of donating protons to stabilize the free radicals ABTS •+ and DPPH • . Free radicals (RL) possess an unpaired electron in the last orbital, which makes them unstable and highly reactive.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…In general, some authors report lower anti-free-radical activity on the ABTS •+ radical in pure compounds. 54 , 55 …”

Section: Resultsmentioning

confidence: 99%

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Tetrandrine Derivatives as Promising Antibacterial Agents

et al. 2023

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This work reports on the antibacterial activity of two tetrandrine derivatives, with acridine (MAcT) and anthracene (MAnT) units, against Gram-positive and Gram-negative bacteria of clinical importance by the broth microdilution method as well as their antioxidant activity against ABTS •+ and DPPH •+ radicals. Unlike natural tetrandrine, its derivatives inhibited bacterial growth, showing selectivity against Staphylococcus aureus with notable activity of MAnT (MIC = 0.035 μg/mL); this compound also has good activity against the ABTS •+ radical (IC 50 = 4.59 μg/mL). Cell membrane integrity studies and reactive oxygen species (ROS) detection by fluorescent stains helped to understand possible mechanisms related to antibacterial activity, while electrophoretic mobility assays showed that the derivatives can bind to bacterial DNA plasmid. The results indicate that MAnT can induce a general state of oxidative stress in S. aureus and Escherichia coli, while MAcT induces an oxidative response in S. aureus. Complementary electrochemical studies were included.

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Section: Resultsmentioning

confidence: 98%

Section: ■ Results and Discussionmentioning

confidence: 99%