First confirmed report of outbreak of malignant ovine theileriosis among goats in Sudan

Taha, Khalid M.; Salih, Diaeldin A.; Ahmed, B.M.; Enan, Khalid A; Ali, Awadia M.; Elhussein, A. M.

doi:10.1007/s00436-011-2428-y

Cited by 24 publications

(12 citation statements)

References 6 publications

(3 reference statements)

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“…Clinical signs include loss of condition, coughing, lethargy, enlargement of lymph nodes, and fever [1]. Mortality levels of up to 73% have been reported for malignant ovine theileriosis [2] and the disease can lead to reduced productivity and spontaneous abortions in survivors [3]. T .…”

Section: Introductionmentioning

confidence: 99%

Identification of Theileria lestoquardi Antigens Recognized by CD8+ T Cells

et al. 2016

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As part of an international effort to develop vaccines for Theileria lestoquardi, we undertook a limited screen to test T. lestoquardi orthologues of antigens recognised by CD8+ T lymphocyte responses against T. annulata and T. parva in cattle. Five MHC defined sheep were immunized by live T. lestoquardi infection and their CD8+ T lymphocyte responses determined. Thirteen T. lestoquardi orthologues of T. parva and T. annulata genes, previously shown to be targets of CD8+ T lymphocyte responses of immune cattle, were expressed in autologous fibroblasts and screened for T cell recognition using an IFNγ assay. Genes encoding T. lestoquardi antigens Tl8 (putative cysteine proteinase, 349 aa) or Tl9 (hypothetical secreted protein, 293 aa) were recognise by T cells from one animal that displayed a unique MHC class I genotype. Antigenic 9-mer peptide epitopes of Tl8 and Tl9 were identified through peptide scans using CD8+ T cells from the responding animal. These experiments identify the first T. lestoquardi antigens recognised by CD8+ T cell responses linked to specific MHC class I alleles.

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Section: Introductionmentioning

confidence: 99%

Identification of Theileria lestoquardi Antigens Recognized by CD8+ T Cells

et al. 2016

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“…Five µl genomic DNA and 150 µg/ml of enhancer (Bovine serum albumin acetylated) were added to final reaction volume of 20 µl. The reaction was performed in a thermal cycler (Applied Bio system, USA) and the thermal cycling conditions were as described by Taha et al [16]. Five µl of each PCR product were visualized in 1.5% ethidium bromide stained gel and run in 1X TBE buffer in electrophoresis chamber.…”

Section: Deoxyribonucleic Acid (Dna) Extraction and Polymerase Chain mentioning

confidence: 99%

Prevalence, First Molecular Identification and Characterization of Theileria lestoquardi in Sheep in Alhuda National Sheep Research Station, Al Gezira State, Sudan

Ahmed

Salih

et al. 2019

AJOB

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“…The disease is highly pathogenic to sheep (Leemans et al, 1999 a,b;Tageldin et al, 2005) and goats (Taha et al, 2011). Even in indigenous sheep breeds, high morbidity and mortality rates were reported (El Hussein et al, 1998;El Imam et al, 2015).…”

Section: Pathogenesismentioning

confidence: 99%

“…In the case of T. lestoquardi, indigenous sheep are at risk in a situation where they are subjected to intensive tick control or when they are moved from disease free to endemic areas (Friedhoff, 1997;Tageldin et al, 2005;El Imam et al, 2015). Globally, high morbidity and mortality rates in sheep and goats were reported (El Hussein et al, 1998;Taha et al, 2011;Tageldin et al, 2005;El Imam et al, 2015). The disease economic importance can therefore be predicted, especially in countries where export of sheep and sheep products are a major component of their foreign income.…”

Section: Economic Impactmentioning

confidence: 99%

Malignant Ovine Theileriosis ( Theileria Lestoquardi ) : A Review

Imam¹,

Taha²

2015

JJBS

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Malignant Ovine Theileriosis (MOT) is a tick borne disease of sheep and goats, caused by Theileria lestoquardi and is considered a major constraint for sheep production in many areas of the world. It has been reported to infect lymphocytes in vivo and in vitro and the schizonts differentiate into macro-schizonts and micro-schizonts. To date, little is known about the mechanisms involved in the disease pathogenesis, but its high mortality is likely to be linked to the ability of T. lestoquardi to stimulate uncontrolled proliferation of the infected leukocyte. Consequently, severe tissue destruction and pulmonary oedema leading to respiratory failure are thought to be the cause of death. Despite an immense amount of small ruminant research, MOT remains an important disease of sheep and goats. Therefore, the present review outlines the current knowledge covering T. lestoquardi transmission, distribution, pathogenesis, diagnosis and control. The information may assist in filling the gaps in our knowledge about the economic impact of the disease and new research initiatives. We conclude that the development of a simple, affordable and applicable diagnostic test for an early detection at the field level, and the production of an effective vaccine could have a significant impact on the control of the disease.

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First confirmed report of outbreak of malignant ovine theileriosis among goats in Sudan

Cited by 24 publications

References 6 publications

Identification of Theileria lestoquardi Antigens Recognized by CD8+ T Cells

Identification of Theileria lestoquardi Antigens Recognized by CD8+ T Cells

Prevalence, First Molecular Identification and Characterization of Theileria lestoquardi in Sheep in Alhuda National Sheep Research Station, Al Gezira State, Sudan

Malignant Ovine Theileriosis ( Theileria Lestoquardi ) : A Review

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