First Clinical Case Report of a Xenograft–Allograft Combination for Alveolar Ridge Augmentation Using a Bovine Bone Substitute Material with Hyaluronate (Cerabone® Plus) Combined with Allogeneic Bone Granules (Maxgraft®)

Kloss, Frank R.; Kämmerer, Peer W.; Kloss-Brandstätter, Anita

doi:10.3390/jcm12196214

Cited by 5 publications

(3 citation statements)

References 54 publications

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“…It is thus considered a slow reabsorption material that is still detectable after more than a decade [8]. Recently, different compounds, such as purified porcine type I collagen and sodium hyaluronate, have been added to this type of xenograft to improve its handling by increasing the cohesion between granules [9,10]. In addition to this, hyaluronic acid has been shown to achieve faster cell proliferation and vascularization and better clinical results [11].…”

Section: Introductionmentioning

confidence: 99%

Effect of Applying 1% Metformin on Guided Bone Regeneration Processes with Bovine-Derived Xenografts

Montalbán-Vadillo,

Pérez-Pevida,

Viteri-Agustín

et al. 2024

JCM

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Background: Although xenografts have shown successful results in GBR procedures due to their osteoconductive properties, many authors have opted to add co-adjuvant drugs to favor osteogenesis and differentiate cells into an osteoblastic lineage. Metformin has been shown to have bone-protective properties, regulating osteoclast differentiation, as well as the ability to promote osteoblast mineralization and differentiation. The present study aimed to evaluate the effect of the local application of a 1% metformin solution on bone neoformation in the treatment of an experimental bone defect in a guided bone regeneration animal model with a particulated bovine hydroxyapatite xenograft with hyaluronate. Methods: With this purpose in mind, two critical defects with 8 mm diameter and 0.5 mm depth were created in eight male New Zealand rabbit calvarias. Titanium cylinders were fixed in each defect and filled with particulate hydroxyapatite of bovine origin and sodium hyaluronate, with sterile injectable saline added to the control group and sterile 1% metformin solution added to the test group. At 6 weeks, the animals were euthanized, and samples were obtained and prepared for histomorphometric analysis. Results: A higher percentage of new bone formation was observed in the metformin samples than in the control samples, both in the region closest to the animal’s calvaria and in the most distal region analyzed. A higher average bone–biomaterial contact percentage was observed in the samples, with metformin in both the proximal and distal regions. There was no statistically significant difference in the mean value in either region in both parameters. Conclusion: The local application of a 1% metformin solution in an animal model of guided bone regeneration with particulate bovine hydroxyapatite and hyaluronate resulted in greater bone neoformation and xenograft osseointegration than in the control group.

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Section: Introductionmentioning

confidence: 99%

Effect of Applying 1% Metformin on Guided Bone Regeneration Processes with Bovine-Derived Xenografts

Montalbán-Vadillo,

Pérez-Pevida,

Viteri-Agustín

et al. 2024

JCM

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“…These issues can be attributed to factors such as trauma during implant surgery, bacterial infiltration in the micro gap, and tissue deformation around the implant [11][12][13]. Many clinical trials are currently underway to solve this problem [14,15]. Further, implant stability has been determined by confirming the degree of the osseointegration of the implant via resonance frequency analysis [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Toward Digital Twin Development for Implant Placement Planning Using a Parametric Reduced-Order Model

Ahn,

Kim,

Baek

et al. 2024

Bioengineering

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Real-time stress distribution data for implants and cortical bones can aid in determining appropriate implant placement plans and improving the post-placement success rate. This study aims to achieve these goals via a parametric reduced-order model (ROM) method based on stress distribution data obtained using finite element analysis. For the first time, the finite element analysis cases for six design variables related to implant placement were determined simultaneously via the design of experiments and a sensitivity analysis. The differences between the minimum and maximum stresses obtained for the six design variables confirm that the order of their influence is: Young’s modulus of the cancellous bone > implant thickness > front–rear angle > left–right angle > implant length. Subsequently, a one-dimensional (1-D) CAE solver was created using the ROM with the highest coefficient of determination and prognosis accuracy. The proposed 1-D CAE solver was loaded into the Ondemand3D program and used to implement a digital twin that can aid with dentists’ decision making by combining various tooth image data to evaluate and visualize the adequacy of the placement plan in real time. Because the proposed ROM method does not rely entirely on the doctor’s judgment, it ensures objectivity.

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“…However, autologous bone grafting has drawbacks such as resorption of the grafted area, insufficient bone volume in the donor area, vulnerability of the donor area to trauma, pain, infection, and sensory abnormalities ( Bernardi et al, 2020 ). As for allogeneic bone grafting, it also faces potential challenges related to immune rejection, tissue compatibility, cross-transmission of diseases, as well as the biological or mechanical properties of the materials used ( Kloss et al, 2023 ; Xu et al, 2021 ). Despite the advantages of both autologous and allogeneic bone grafting, concerns regarding their application have led to the development of many bone substitutes.…”

Section: Introductionmentioning

confidence: 99%

Preliminary study on the preparation of antler powder/chitosan/β-glycerophosphate sodium/polyvinyl alcohol porous hydrogel scaffolds and their osteogenic effects

Abudukelimu,

Aierken,

Tuerxuntayi

et al. 2024

Front. Bioeng. Biotechnol.

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Introduction: The production of bone-like structural scaffolds through bone tissue engineering technology is a promising method for bone regeneration to repair bone defects. Deer antler, an easily harvested and abundantly sourced initial bone tissue structure, resembles the composition and structure of human cancellous bone and can serve as a new material for allogeneic bone transplantation.Methods: This study involved the preparation and characterization of antler powder/chitosan/β-glycerophosphate sodium/polyvinyl alcohol (AP/CS/β-GP/PVA) porous hydrogel scaffolds to verify their material properties and osteogenic mechanisms. The microstructure, hydrophilicity, and mechanical properties of the scaffolds were studied using Scanning Electron Microscopy (SEM), contact angle measurement, and a universal material testing machine. The interactions between the various components were investigated using Fourier-Transform Infrared Spectroscopy (FTIR). Biocompatibility, osteogenic properties, and expression of osteogenesis-related proteins of the scaffolds were evaluated through Cell Counting Kit-8 (CCK-8) assays, alkaline phosphatase staining, Alizarin Red staining, live/dead cell staining, and Western blot analysis.Results: The results showed that as the content of deer antler powder increased, both the hydrophilicity and mechanical properties of the scaffold materials improved, while the porosity slightly decreased with an increase in deer antler powder content. Cell culture experiments demonstrated that scaffolds with a higher proportion of deer antler powder were beneficial for the proliferation and differentiation of mouse pre-osteoblast (MC3T3-E1) cells, with the scaffolds containing 10% and 8% deer antler powder showing the best effects. The upregulation of RUNX2, OCN, OSX, and OPN protein expression may promote differentiation.Discussion: Therefore, the AP/CS/β-GP/PVA hydrogel scaffolds have the potential to become a promising biomaterial for bone tissue engineering.

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First Clinical Case Report of a Xenograft–Allograft Combination for Alveolar Ridge Augmentation Using a Bovine Bone Substitute Material with Hyaluronate (Cerabone® Plus) Combined with Allogeneic Bone Granules (Maxgraft®)

Cited by 5 publications

References 54 publications

Effect of Applying 1% Metformin on Guided Bone Regeneration Processes with Bovine-Derived Xenografts

Effect of Applying 1% Metformin on Guided Bone Regeneration Processes with Bovine-Derived Xenografts

Toward Digital Twin Development for Implant Placement Planning Using a Parametric Reduced-Order Model

Preliminary study on the preparation of antler powder/chitosan/β-glycerophosphate sodium/polyvinyl alcohol porous hydrogel scaffolds and their osteogenic effects

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