First clinical case of tick-borne encephalitis (TBE) in a dog in Greece

Sioutas, Georgios; Tsakou, Kyriaki; Top, Cihan; Jongejan, Frans; Papadopoulos, Elias

doi:10.1016/j.ttbdis.2023.102226

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…Three dogs (3.4% (3/88); CI 95% 0.7-9.6)) were found to be TBEV PCR-positive and concurrently diagnosed with A. phagocytophilum infection. However, there are previously reported clinical TBE cases in dogs with high antibody levels against A. phagocytophilum and Ehrlichia canis in blood serum [32,33]. Concurrent TBE and Babesia spp.…”

Section: Discussionmentioning

confidence: 97%

The Prevalence, Seroprevalence, and Risk Factors of Tick-Borne Encephalitis Virus in Dogs in Lithuania, a Highly Endemic State

Simkute,

Pautienius,

Grigas

et al. 2023

Viruses

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The rising awareness and increasing number of case reports of tick-borne encephalitis (TBE) in dogs indicate that the virus might be an important tick-borne pathogen in dogs, especially in endemic areas. Therefore, the aim of the present study was to investigate the prevalence rate of TBEV RNA and TBEV-specific antibodies in clinical samples of dogs living in a highly endemic region of Lithuania and to evaluate the main risk factors for severe disease course and death. The blood samples (n = 473) of dogs were collected in two veterinary clinics in central Lithuania. Tick-borne encephalitis virus (TBEV) RNA was detected in 18.6% (88/473; CI 95% 15.2–22.4) and TBEV-specific antibodies were found in 21.6% (102/473; CI 95% 17.9–25.6) of dog blood serum samples after confirmation with a virus neutralization test. The death/euthanasia rate was 18.2% (16/88; CI 95% 10.8–27.8) in PCR-positive dogs. Male dogs were more likely to develop neurological symptoms (p = 0.008). Older dogs (p = 0.003), dogs with the presence of neurological symptoms (p = 0.003), and dogs with the presence of TBEV-specific antibodies (p = 0.024) were more likely to experience worse outcomes of the disease. The results of the present study demonstrate that TBEV is a common and clinically important pathogen in dogs in such endemic countries as Lithuania.

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Section: Discussionmentioning

confidence: 97%

The Prevalence, Seroprevalence, and Risk Factors of Tick-Borne Encephalitis Virus in Dogs in Lithuania, a Highly Endemic State

Simkute,

Pautienius,

Grigas

et al. 2023

Viruses

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“…Clinical TBEV cases in animals are rare but have been reported in horses [ 12 ] and dogs [ 13 ]. Other animal species such as goats, sheep, and cattle develop TBEV antibodies without showing clinical signs.…”

Section: Introductionmentioning

confidence: 99%

An Overview of Tick-Borne Encephalitis Epidemiology in Endemic Regions of Continental Croatia, 2017–2023

Vilibic-Cavlek,

Krcmar,

Bogdanic

et al. 2024

Microorganisms

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Background: Tick-borne encephalitis (TBE) represents an important public health problem in Europe. We analyzed the epidemiology of TBE based on data from humans, animals, and Ixodes ricinus ticks in endemic regions of continental Croatia. Methods: In the period from 2017 to 2023, cerebrospinal fluid (CSF) and serum samples of 684 patients with neuroinvasive diseases, 2240 horse serum samples, and 300 sheep serum samples were tested for TBEV. In addition, 8751 I. ricinus ticks were collected. CSF samples were tested using RT-PCR. Serological tests (serum, CSF) were performed using commercial ELISA, with confirmation of cross-reactive samples by a virus neutralization test. Results: Eighty-four autochthonous human TBEV cases were confirmed. The majority of patients were in the age group of 40–69 years (58.3%) with a male predominance (70.2%). TBE showed a bimodal seasonality with a large peak in April–August and a small one in October–November. In addition to humans, TBEV IgG antibodies were found in 12.2% of horses and 9.7% of sheep. Seasonal tick abundance corresponds to the reported number of human infections. Conclusions: Continental Croatia is still an active natural focus of TBE. Continuous monitoring of infections in humans, sentinel animals, and ticks is needed for the implementation of preventive measures.

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Efficacy and immunogenicity of a veterinary vaccine candidate against tick-borne encephalitis in dogs

Salat,

Hunady,

Svoboda

et al. 2023

Vaccine

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First clinical case of tick-borne encephalitis (TBE) in a dog in Greece

Cited by 3 publications

References 19 publications

The Prevalence, Seroprevalence, and Risk Factors of Tick-Borne Encephalitis Virus in Dogs in Lithuania, a Highly Endemic State

The Prevalence, Seroprevalence, and Risk Factors of Tick-Borne Encephalitis Virus in Dogs in Lithuania, a Highly Endemic State

An Overview of Tick-Borne Encephalitis Epidemiology in Endemic Regions of Continental Croatia, 2017–2023

Efficacy and immunogenicity of a veterinary vaccine candidate against tick-borne encephalitis in dogs

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