First Chemical Constituents from Cordia exaltata Lam and Antimicrobial Activity of Two Neolignans

Nogueira, Tiago Bezerra de Sá de Sousa; Nogueira, Renato Luiz Maia; Silva, Davi Antas e; Tavares, Josean Fechine; Lima, Edeltrudes de Oliveira; Pereira, Fillipe de Oliveira; Fernandes, Milen Maria Magalhães de Souza; Medeiros, Fernando Antônio de; Sarquis, Rosângela do Socorro Ferreira Rodrigues; Braz-Filho, Raimundo; Maciel, Jéssica Karina da Silva; Souza, María de Fátima Vanderlei de

doi:10.3390/molecules180911086

Cited by 12 publications

(3 citation statements)

References 32 publications

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“…13 C-NMR (125 MHz) (CD 3 OD) δ: 159.4 (C-2), 137.4 (C-3), 179.3 (C-4), 162.8 (C-5), 100.0 (C-6), 166.6 (C-7), 94.9 (C-8), 158.5 (C-9), 105.5 (C-10), 122.6 (C-1′), 132.3 (C-2′/6′), 116.1 (C-3′/5′), 161.4 (C-6′), 104.5 (C-1′′), 71.3 (C-2′′), 78.0 (C-3′′), 75.6 (C-4′′), 69.7 (C-5′′), 68.5 (C-6′′), 102.3 (C-1′′′), 72.0 (C-2′′′), 72.2 (C-3′′′), 77.1 (C-4′′′), 73.8 (C-5′′′) and 17.9 (C-6′′′). In agreement with literature [ 10 ].…”

Section: Resultssupporting

confidence: 93%

Alkaloids and Phenolic Compounds from Sida rhombifolia L. (Malvaceae) and Vasorelaxant Activity of Two Indoquinoline Alkaloids

et al. 2017

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The follow-up of phytochemical and pharmacological studies of Sida rhombifolia L. (Malvaceae) aims to strengthen the chemosystematics and pharmacology of Sida genera and support the ethnopharmacological use of this species as hypotensive herb. The present work reports phytoconstituents isolated and identified from aerial parts of S. rhombifolia by using chromatographic and spectroscopic methods. The study led to the isolation of scopoletin (1), scoporone (2), ethoxy-ferulate (3), kaempferol (4), kaempferol-3-O-β-d-glycosyl-6′′-α-d-rhamnose (5), quindolinone (6), 11-methoxy-quindoline (7), quindoline (8), and the cryptolepine salt (9). The alkaloids quindolinone (6) and cryptolepine salt (9) showed vasorelaxant activity in rodent isolated mesenteric arteries.

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Section: Resultssupporting

confidence: 93%

Alkaloids and Phenolic Compounds from Sida rhombifolia L. (Malvaceae) and Vasorelaxant Activity of Two Indoquinoline Alkaloids

et al. 2017

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“…13 2 -hydroxy-pheophytin a is an allomerized product of pheophytin a. It has previously been reported in other plants such as Plagiochila ovalifolia , Cordia exaltata and Clinacanthus nutans [ 29 , 51 , 52 ]. Although the other compound, 13 1 -hydroxy-13 2 -oxo-pheophytin a, is expected to exist as an oxidised product of pheophytin a, isolation of this compound from plants has never been reported probably due to its instability and rapid conversion into other allomerized products [ 53 ].…”

Section: Discussionmentioning

confidence: 96%

Anti-Tumor Action, Clinical Biochemistry Profile and Phytochemical Constituents of a Pharmacologically Active Fraction of S. crispus in NMU-Induced Rat Mammary Tumour Model

et al. 2015

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Cancer patients seek alternative remedies such as traditional medicinal plants for safe and effective treatment and help overcome the side effects of conventional therapy. Current knowledge indicates that extracts of Strobilanthes crispus of the Acanthaceae family exhibit potent anticancer properties in vitro and are non-toxic in vivo. S. crispus was also reported to be protective against chemical hepatocarcinogenesis. We previously showed that a bioactive fraction of S. crispus leaves also synergized with tamoxifen to cause apoptosis of human breast cancer cell lines without damaging non-malignant epithelial cells. The present study aimed to evaluate the antitumor effect of S. crispus dichloromethane fraction (F3) using N-methyl-N-Nitrosourea (NMU)-induced rat mammary tumor model. Tumor regression was observed in 75% of the rats following 8-week oral administration of F3 with no secondary tumour formation and no signs of anemia or infection. However, no improvement in the liver and renal function profiles was observed. Major constituents of F3 were identified as lutein, 131-hydroxy-132-oxo-pheophytin a, campesterol, stigmasterol, β-sitosterol, pheophytin a and 132-hydroxy-pheophytin a. These compounds however, may not significantly contribute to the antitumor effect of F3.

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“…In this study, thirty-four compounds ( 1 – 34 ) were isolated from the aerial parts of F. dentatoalata via extensive column chromatography. These were identified as apigenin ( 1 ) ( Ha et al, 2012 ), isovitexin ( 2 ) ( Jayasinghe et al, 2004 ), kaempferol ( 3 ) ( Fukai and Nomura, 1988 ), afzelin ( 4 ) ( Xu et al, 2009 ), astragalin ( 5 ) ( Otsuka et al, 1989 ), kaempferol-3-rutinoside ( 6 ) ( de Sa de Sousa Nogueira et al, 2013 ), luteolin ( 7 ) ( Zhang et al, 2015 ), quercetin ( 8 ) ( Lesjak et al, 2018 ), guaijaverin ( 9 ) ( Yoshida et al, 1992 ), hyperoside ( 10 ) ( Isaza et al, 2001 ), tamarixetin-3-rhamnoside ( 11 ) ( Norman et al, 2021 ), quercitrin ( 12 ) ( Chen et al, 2008 ), isoquercitrin ( 13 ) ( Jin et al, 2009 ), rutin ( 14 ) ( Kazuma et al, 2003 ), quercetin-3- O -robinoside ( 15 ) ( Dossou et al, 2021 ), myricetin ( 16 ) ( Zhang et al, 2004 ), myricitrin ( 17 ) ( Kil et al, 2019 ), (+)-catechin ( 18 ) ( Foo et al, 1997 ), (-)-epicatechin ( 19 ) ( Lin and Lee, 2010 ), zizyflavoside B ( 20 ) ( Yang et al, 2020 ), emodin ( 21 ) ( Meselhy, 2003 ), physcion ( 22 ) ( Jo et al, 2011 ), glucofrangulin A ( 23 ) ( Bezabih and Abegaz, 1998 ), torachrysone-8- O -β-D-glucoside ( 24 ) ( Zhao et al, 2017 ), polydatin ( 25 ) ( Yi et al, 2020 ), tetrahydroxystilbene-2- O -β-D-glucoside ( 26 ) ( Tsai et al, 2018 ), ( E )-2,3,5,4′-tetrahydroxystilbene-2- O -(2″- O -galloyl)-β-D-glucoside ( 27 ) ( Nguyen et al, 2020 ), protocatechuic acid ( 28 ) ( Meng et al, 2021b ), gallic acid ( 29 ) ( Chen et al, 2021 ), lapathoside B ( 30 ) ( Takasaki et al, 2001 ), vanicoside B ( 31 ) ( Kumagai et al, 2005 ), lapathoside A ( 32 ) ( Takasaki et al, 2001 ), smilaside J ( 33 ) ( Zhang et al, 2008 ), and smilaside G ( 34 ) ( Takasaki et al, ...…”

Section: Resultsmentioning

confidence: 99%

In Vitro and in Silico Analysis of Phytochemicals From Fallopia dentatoalata as Dual Functional Cholinesterase Inhibitors for the Treatment of Alzheimer’s Disease

et al. 2022

Front. Pharmacol.

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Current studies have found that butyrylcholinesterase (BuChE) replaces the biological function of acetylcholinesterase (AChE) in the late stage of Alzheimer’s disease. Species in the genus of Fallopia, rich in polyphenols with diverse chemical structures and significant biological activities, are considered as an important resource for screening natural products to against AD. In this study, thirty-four compounds (1–34) were isolated from Fallopia dentatoalata (Fr. Schm.) Holub, and their inhibitory effects against AChE and BuChE were assessed. Compounds of the phenylpropanoid sucrose ester class emerged as the most promising members of the group, with 31–33 displaying moderate AChE inhibition (IC50 values ranging from 30.6 ± 4.7 to 56.0 ± 2.4 µM) and 30–34 showing potential inhibitory effects against BuChE (IC50 values ranging from 2.7 ± 1.7 to 17.1 ± 3.4 µM). Tacrine was used as a positive control (IC50: 126.7 ± 1.1 in AChE and 5.5 ± 1.7 nM in BuChE). Kinetic analysis highlighted compounds 31 and 32 as non-competitive inhibitors of AChE with Ki values of ∼30.0 and ∼34.4 µM, whilst 30–34 were revealed to competitively inhibit BuChE with Ki values ranging from ∼1.8 to ∼17.5 µM. Molecular binding studies demonstrated that 30–34 bound to the catalytic sites of BuChE with negative binding energies. The strong agreement between both in vitro and in silico studies highlights the phenylpropanoid sucrose esters 30–34 as promising candidates for use in future anti-cholinesterase therapeutics against Alzheimer’s disease.

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First Chemical Constituents from Cordia exaltata Lam and Antimicrobial Activity of Two Neolignans

Abstract: Abstract:The phytochemical study of Cordia exaltata

Cited by 12 publications

References 32 publications

Alkaloids and Phenolic Compounds from Sida rhombifolia L. (Malvaceae) and Vasorelaxant Activity of Two Indoquinoline Alkaloids

Alkaloids and Phenolic Compounds from Sida rhombifolia L. (Malvaceae) and Vasorelaxant Activity of Two Indoquinoline Alkaloids

Anti-Tumor Action, Clinical Biochemistry Profile and Phytochemical Constituents of a Pharmacologically Active Fraction of S. crispus in NMU-Induced Rat Mammary Tumour Model

In Vitro and in Silico Analysis of Phytochemicals From Fallopia dentatoalata as Dual Functional Cholinesterase Inhibitors for the Treatment of Alzheimer’s Disease

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