First Characterization of The Venom from Apis mellifera syriaca, A Honeybee from The Middle East Region

Frangieh, Jacinthe; Salma, Yahya; Haddad, Katia; Mattei, César; Legros, Christian; Fajloun, Ziad; Obeid, Dany

doi:10.3390/toxins11040191

Cited by 47 publications

(42 citation statements)

References 35 publications

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“…Interestingly, its activity can be improved by melittin. This has been shown to occur during the process of erythrocyte lysis, proving the presence of synergistic action between both bvPLA 2 and melittin [36,37]. In fact, it has been demonstrated that melittin helps in exposing membrane phospholipids to the catalytic site of enzymes via opening melittin-induced channels [38].…”

Section: Main Compounds Of Bee Venommentioning

confidence: 99%

Bee Venom: Overview of Main Compounds and Bioactivities for Therapeutic Interests

et al. 2019

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Apitherapy is an alternate therapy that relies on the usage of honeybee products, most importantly bee venom for the treatment of many human diseases. The venom can be introduced into the human body by manual injection or by direct bee stings. Bee venom contains several active molecules such as peptides and enzymes that have advantageous potential in treating inflammation and central nervous system diseases, such as Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis. Moreover, bee venom has shown promising benefits against different types of cancer as well as anti-viral activity, even against the challenging human immunodeficiency virus (HIV). Many studies described biological activities of bee venom components and launched preclinical trials to improve the potential use of apitoxin and its constituents as the next generation of drugs. The aim of this review is to summarize the main compounds of bee venom, their primary biological properties, mechanisms of action, and their therapeutic values in alternative therapy strategies.

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Section: Main Compounds Of Bee Venommentioning

confidence: 99%

Bee Venom: Overview of Main Compounds and Bioactivities for Therapeutic Interests

et al. 2019

Self Cite

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“…Bee venom contains several biologically active molecules such as peptides, bioactive amines and enzymes, which have an advantageous potential in healing the wounds. Bee venom contains different peptides including melittin, apamin, adolapin, secapin and its isomers (i.e., secapin-1 and -2), procamine, tertiapin and mast cell degranulating peptide (MCD-peptides) [ 22 , 23 ].…”

Section: Chemical Composition Of Bee Venommentioning

confidence: 99%

Bee Venom in Wound Healing

et al. 2020

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Bee venom (BV), also known as api-toxin, is widely used in the treatment of different inflammatory diseases such as rheumatoid arthritis or multiple sclerosis. It is also known that BV can improve the wound healing process. BV plays a crucial role in the modulation of the different phases of wound repair. It possesses anti-inflammatory, antioxidant, antifungal, antiviral, antimicrobial and analgesic properties, all of which have a positive impact on the wound healing process. The mentioned process consists of four phases, i.e., hemostasis, inflammation, proliferation and remodeling. The impaired wound healing process constitutes a significant problem especially in diabetic patients, due to hypoxia state. It had been found that BV accelerated the wound healing in diabetic patients as well as in laboratory animals by impairing the caspase-3, caspase-8 and caspase-9 activity. Moreover, the activity of BV in wound healing is associated with regulating the expression of transforming growth factor (TGF-β1), vascular endothelial growth factor and increased collagen type I. BV stimulates the proliferation and migration of human epidermal keratinocytes and fibroblasts. In combination with polyvinyl alcohol and chitosan, BV significantly accelerates the wound healing process, increasing the hydroxyproline and glutathione and lowering the IL-6 level in wound tissues. The effect of BV on the wounds has been proved by numerous studies, which revealed that BV in the wound healing process brings about a curative effect and could be applied as a new potential treatment for wound repair. However, therapy with bee venom may induce allergic reactions, so it is necessary to assess the existence of the patient’s hypersensitivity to apitoxin before treatment.

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“…Venomous animals have been a focus of interest for humans for years due to the danger associated with them and the possibility of taking advantage of venom action and utilizing it in medicine [1,2]. Animal venoms are immensely complex mixtures composed of proteins, peptides, biogenic amines, and other substances of low-molecular weight, which are often enzymatically active [3,4,5]. Especially, the great interest is related to the biological activity of proteins isolated from bee (melittin, apamina and tertiapin) and wasp (mastoparan and bradykinin) venoms [2].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Bee Venom Melittin on the Functioning of the Immune System and the Contractile Activity of the Insect Heart—A Preliminary Study

Lubawy

Urbański

Mrówczyńska

et al. 2019

Toxins

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Melittin (MEL) is a basic polypeptide originally purified from honeybee venom. MEL exhibits a broad spectrum of biological activity. However, almost all studies on MEL activity have been carried out on vertebrate models or cell lines. Recently, due to cheap breeding and the possibility of extrapolating the results of the research to vertebrates, insects have been used for various bioassays and comparative physiological studies. For these reasons, it is valuable to examine the influence of melittin on insect physiology. Here, for the first time, we report the immunotropic and cardiotropic effects of melittin on the beetle Tenebrio molitor as a model insect. After melittin injection at 10−7 M and 10−3 M, the number of apoptotic cells in the haemolymph increased in a dose-dependent manner. The pro-apoptotic action of MEL was likely compensated by increasing the total number of haemocytes. However, the injection of MEL did not cause any changes in the percent of phagocytic haemocytes or in the phenoloxidase activity. In an in vitro bioassay with a semi-isolated Tenebrio heart, MEL induced a slight chronotropic-positive effect only at a higher concentration (10−4 M). Preliminary results indicated that melittin exerts pleiotropic effects on the functioning of the immune system and the endogenous contractile activity of the heart. Some of the induced responses in T. molitor resemble the reactions observed in vertebrate models. Therefore, the T. molitor beetle may be a convenient invertebrate model organism for comparative physiological studies and for the identification of new properties and mechanisms of action of melittin and related compounds.

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First Characterization of The Venom from Apis mellifera syriaca, A Honeybee from The Middle East Region

Cited by 47 publications

References 35 publications

Bee Venom: Overview of Main Compounds and Bioactivities for Therapeutic Interests

Bee Venom: Overview of Main Compounds and Bioactivities for Therapeutic Interests

Bee Venom in Wound Healing

The Influence of Bee Venom Melittin on the Functioning of the Immune System and the Contractile Activity of the Insect Heart—A Preliminary Study

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