First case report of pancreatic myeloid sarcoma diagnosed through EUS-FNA

Nunes, Gonçalo; Pinto-Marques, Pedro; Mendonça, Evelina; Gargaté, Luís

doi:10.1016/j.gastrohep.2019.04.008

Cited by 6 publications

(11 citation statements)

References 5 publications

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“…To our knowledge, we report the eighth case of pancreatic MS in a patient without a coexisting or primary hematological malignancy that has been described in the literature [12][13][14].…”

Section: Discussionmentioning

confidence: 94%

“…Once diagnosed, it becomes fundamental to determine whether MS is occurring de novo or coinciding with a myeloid neoplasm. Thus, bone marrow biopsy remains paramount due to highly variable outcomes [12,13].…”

Section: Discussionmentioning

confidence: 99%

“…In most isolated pancreatic cases, a final diagnosis is obtained following surgical resection and histopathology interpretation of the lesion, such as in our patient. However, recently endoscopic ultrasound with fine needle aspiration has determined to be useful or pancreatic mass sampling [12]. Using this modality, when applicable, would help establish a diagnosis rapidly.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the fact that isolated pancreatic MS can be treated with radiotherapy or surgical resection, AML-type remission induction chemotherapy is mandatory after resection of the isolated MS lesion. Otherwise, MS would recur [12,[15][16][17][18][19]. In addition, time to progression to acute leukemia has been shown to be longer in those treated with systemic chemotherapy as opposed to local radiotherapy or surgery [11].…”

Section: Discussionmentioning

confidence: 99%

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Pancreatic Myeloid Sarcoma

Al-Obaidi

Parker

Agha

et al. 2020

Cureus

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Myeloid sarcoma is an isolated extramedullary tumor mass consisting of immature myeloid cells. It is characterized by highly variable outcomes and usually disrupts the normal architecture of the normal tissue in which it originates. It may occur de novo or be associated with other hematological malignancies. Clinical presentation of myeloid sarcomas can be highly variable based on the tumor site, size, and extent of tissue involvement. The diagnosis of myeloid sarcoma is challenging and requires a high index of suspicion. Tissue sampling followed by the use of auxiliary studies is essential for diagnosis. Moreover, bone marrow sampling is necessary to exclude morrow involvement. Currently, the recommended therapeutic regimens for myeloid sarcoma are similar to those for acute myeloid leukemia. Much work remains to be accomplished as myeloid sarcomas, if initially missed or misdiagnosed, have poor overall survival rates. Furthermore, prognostic factors for this malignancy remain poorly understood.

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“…To our knowledge, we report the eighth case of pancreatic MS in a patient without a coexisting or primary hematological malignancy that has been described in the literature [12][13][14].…”

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pancreatic Myeloid Sarcoma

Al-Obaidi

Parker

Agha

et al. 2020

Cureus

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“…4). 4 Endoscopic ultrasound fine-needle aspiration has been recommended as a diagnostic tool in cases of pancreatic MS 41 …”

Section: Diagnosismentioning

confidence: 99%

Myeloid Sarcoma: A Primer for Radiologists

Chiu

Yoon

Tirumani

et al. 2023

J Comput Assist Tomogr

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Myeloid sarcoma (MS) is a rare extramedullary neoplasm that can present in association with acute myeloid leukemia, most commonly in children younger than 15 years. This unique extramedullary malignancy may involve a variety of different organ systems and can present following, preceding, simultaneous with, or in insolation to acute myeloid leukemia. Common areas of extramedullary involvement include soft tissues, bones, lymph nodes, and the peritoneum. Imaging plays a critical role in the diagnosis and management of MS, with commonly used modalities including positron emission tomography-computed tomography, magnetic resonance imaging, computerized tomography, and ultrasound. The purpose of this review article is to provide radiologists with a comprehensive guide summarizing the relevant imaging and clinical features of MS, with emphasis on the role of imaging in the diagnosis, treatment, and follow-up of patients with MS. The relevant pathophysiology, epidemiology, clinical presentations, and differential diagnosis of MS will be reviewed. The relevance of different imaging modalities in diagnosis, monitoring of treatment response, and assessment of treatment-related complications will also be outlined. Through summarizing these topics, this review article aims to provide radiologists with a guide for understanding the existing knowledge of MS in the literature and the current role of imaging in the management of this unique malignancy.

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