First case report of neurobrucellosis associated with hydrocephalus

Güney, Figen; Gümüş, Haluk; Öğmegül, Ayşegül; Kandemir, Bahar; Emlik, Dilek; Arslan, Uğur; Tuncer, İnci

doi:10.1016/j.clineuro.2008.04.002

Cited by 11 publications

(7 citation statements)

References 13 publications

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“…Moreover, granulomatous inflammation within the CSF space may block CSF reuptake by arachnoid villi, causing hydrocephalus. 19 In our study, hydrocephalus was seen in 1.5% of the cases. Disturbances of orientation, memory, attention, and poverty of content due to neurobrucellosis can be seen with the absence of either unconsciousness or deterioration in general status.…”

Section: Discussionsupporting

confidence: 48%

Overview of neurobrucellosis: a pooled analysis of 187 cases

Gül

Erdem

Bek

2009

International Journal of Infectious Diseases

153

135

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Central nervous system involvement is a serious complication of brucellosis; data found in the literature are generally restricted to case reports and case series. In this study we pooled the data from Turkish medical practice in order to gain a thorough understanding of the subject. A search of Turkish publications on chronic neurobrucellosis was made using both Turkish and international databases. A total of 35 publications were analyzed and 187 neurobrucellosis cases were evaluated. Headache, fever, sweating, weight loss, and back pain were the predominant symptoms, while meningeal irritation, confusion, hepatomegaly, hypoesthesia, and splenomegaly were the most frequent findings. The major complications in patients were cranial nerve involvement, polyneuropathy/radiculopathy, depression, paraplegia, stroke, and abscess formation. Antibiotics were used in different combinations and over different intervals. The duration of antibiotic therapy reported ranged from 2 to 15 months (median 5 months). The mortality was 0.5% with suitable antibiotics. Neurobrucellosis may mimic various pathologies. For this reason, a thorough evaluation of the patient with probable disease is crucial for an accurate diagnosis and proper management of the disease.

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Section: Discussionsupporting

confidence: 48%

Overview of neurobrucellosis: a pooled analysis of 187 cases

Gül

Erdem

Bek

2009

International Journal of Infectious Diseases

153

135

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“…Therefore the diagnosis of neurobrucellosis requires demonstration of meningeal infl ammation, abnormal CSF fi ndings, and direct or indirect evidence of Brucella spp. in CSF (11,12,33). In our study, these criteria were considered in the diagnosis of neurobrucellosis.…”

Section: Discussionmentioning

confidence: 99%

“…Hemorrhages, transient ischemic attacks, and venous thrombosis are meningovascular complications of neurobrucellosis (31,32). As for concurrent fi nding of hydrocephalus and infarction in association with neurobrucellosis, no cases have been reported in literature so far, while hydrocephalus alone has already been, albeit seldom, reported (33)(34)(35). In addition, neurobrucellosis presenting with a focal brain mass has been seldom demonstrated by imaging studies (36).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of children with neurobrucellosis

Akbayram¹,

Doğan²,

Peker³

et al. 2012

BLL

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Background: Brucellosis is an endemic disease in many areas throughout the world. Central nervous system involvement is a serious complication of brucellosis with a ratio of 4-11% of all patients. Aim: to describe our experience in diagnosis, treatment, and outcome of 25 pediatric patients with neurobrucellosis. Patients and methods: This study included a review of medical records of patients who were diagnosed with neurobrucellosis between March 2001 and March 2009. Patients who had both clinical fi ndings consistent with neurobrucellosis and positive microbiologic/serologic examinations of CSF with abnormal CSF fi ndings were enrolled in the study. Results: The study included 25 patients between 1 and 15 years of age (mean 8.8 years), while 15 were males and 10 were females. Most of the patients (52 %) were in the age group of 5-9 years with male predominance. The distribution of cases showed density in June and February. The most commonly presented complaints were headache, fever and sweating while the most commonly observed fi ndings were fever and meningeal irritation signs. All patients had positive cerebrospinal fl uid agglutination test for brucellosis. Four different regimens were used based on ceftriaxone, doxycycline, cotrimoxasole, streptomycin, and rifampicin. One patient died, three patients were discharged with sequel, and the remaining patients (84 %) were discharged with full recovery. Conclusion: Clinicians, especially those providing health services in endemic areas like Turkey, should keep in mind that neurobrucellosis can be involved in patients with unexplained symptoms like memory impairment or in patients diagnosed with meningitis (Tab. 5, Fig, 2, Ref. 39).

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“…Inflamasi di dalam ruang CSS menyebabkan hambatan ambilan CSS oleh vili araknoid sehingga terjadi hidrosefalus komunikans. 23 …”

Section: Pembahasanunclassified

Profil Klinis dan Faktor Risiko Hidrosefalus Komunikans dan Non Komunikans pada Anak di RSUD dr. Soetomo

Rahmayani

Gunawan

Utomo

2017

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Latar belakang. Hidrosefalus merupakan salah satu kelainan kongenital tersering pada anak yang dapat menyebabkan penurunan kualitas hidup anak. Penyebab hidrosefalus masih belum banyak diketahui dan faktor risikonya belum banyak dipelajari. Tujuan. Mengevaluasi dan mengidentifikasi faktor risiko yang berhubungan dengan terjadinya hidrosefalus komunikans dan non komunikans pada anak. Metode. Penelitian analitik observasional pada 80 pasien anak yang menderita hidrosefalus dengan menggunakan data sekunder di pusat rekam medis RSUD dr. Soetomo. Analisis menggunakan chi-square dan regresi logistik. Hasil. Prevalensi hidrosefalus komunikans dan non komunikans adalah 41,25% dan 58,75%. Hasil analisis menunjukkan meningoensefalitis memiliki hubungan dengan hidrosefalus komunikans (p=0,023). Data statistik menunjukkan bahwa manifestasi klinis terbanyak pada hidrosefalus adalah edema otak. Background. Hydrocephalus is one of the most common congenital disease in children leading to decrease quality of life. The cause of hydrocephalus is still poorly understood and its risk factors have not been much studied.Objective. To evaluate and identify the risk factors associated with pediatric communicating and non communicating hydrocephalus.Method. An analitic observational study, that was conducted in 80 pediatric patient who suffer hydrocephalus using secondary data at center of medical records in RSUD dr. Soetomo. Analysis using Chi-squre and binary logistic regression. Result. Prevalence of communicating hydrocephalus is 41,25% and prevalence of non-communicating hydrocephalus is 58,75%. The result showed that meningoencephalitis has correlation to communicating hydrocephalus(sig=0.023). Statistic data showed the most clinical manifestation of hydrocephalus is brain edema. Conclusion.Meningoencephalitis is a risk factor of communicating hydrocephalus.

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First case report of neurobrucellosis associated with hydrocephalus

Cited by 11 publications

References 13 publications

Overview of neurobrucellosis: a pooled analysis of 187 cases

Overview of neurobrucellosis: a pooled analysis of 187 cases

Evaluation of children with neurobrucellosis

Profil Klinis dan Faktor Risiko Hidrosefalus Komunikans dan Non Komunikans pada Anak di RSUD dr. Soetomo

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