First case report of isolated penile mucormycosis in a liver transplantation recipient

Abstract

Mucormycosis is a rare but potentially lethal complication of liver transplantation. Most reported cases have involved rhinocerebral, pulmonary, gastrointestinal, or disseminated forms. We present herein the case of a 61-year-old male patient with hepatocellular carcinoma who developed isolated penile mucormycosis after orthotopic liver transplantation. Such a case has not been reported in the literature to date. Early diagnosis and timely surgical intervention combined with comprehensive treatment are the key factors for improving the survival rate in patients with mucormycosis.

Breakthrough Penile Mucormycosis in a Patient With Acute Myelogenous Leukemia on Posaconazole Prophylaxis

“…After a review of the current literature, we found only 8 other published case reports of mucormycosis with male genitalia involvement (Table 1). 14–21 …”

“…11,13,14 After a review of the current literature, we found only 8 other published case reports of mucormycosis with male genitalia involvement (Table 1). [14][15][16][17][18][19][20][21] Persistent neutropenia, immunosuppressive therapy, high-dose steroid therapy, diabetes mellitus, metabolic acidosis, illicit IV drug use, and trauma are commonly seen in patients with mucormycosis. 2,[9][10][11][12][13] In our patient, the most important predisposing factor was severe neutropenia.…”

Case report of penile Rhizopus arrhizus infection in an unexpected patient

“…Cutaneous infections involving the penis are very rare and mucormycosis is often not considered as a possible diagnosis leading to delays in recognition of the condition and delay in appropriate care [1,4]. Multiple reports describe mucormycosis presenting as Fournier's gangrene or solitary lesions in solid organ transplant patients or patients with active hematologic malignancies [[6], [7], [8]]. A similar case of mucormycosis of the penis was reported in a patient with diabetic ketoacidosis.…”