First case report of infection caused by Cupriavidus gilardii in a non-immunocompromised Chinese patient

Abstract

Cupriavidus gilardii was first identified as an aerobic, gram-negative, glucose-nonfermenting rod. C. gilardii has been characterized as an organism with low pathogenicity that causes opportunistic infections and few case reports of infection caused by this organism previously. We encountered the first case of bloodstream infection caused in China by C. gilardii in a 87-year old man without obvious immunodeficiency. The isolate were identified as C. gilardii by 16S rRNA sequencing. The infected patient was treated according to the laboratory’s antibiogram of this strain. Similar to the case report in Japan, this is the second report of an infection caused by this organism without obvious immunodeficiency, suggesting that C. gilardii exerts its pathogenicity both in immunodeficient and immunocompetent hosts.

Molecular analysis of oral microflora in patients with primary Sjögren’s syndrome by using high-throughput sequencing

“…Twenty-two unique genera were detected in the rinse samples of pSS patients; most of the species, such as Kocuria rosea , Cupriavidus gilardii and Anaerococcus prevotii , are opportunistic pathogens that can cause infectious processes ( Savini et al, 2010 ; Chiu & Wang, 2013 ; Tennert et al, 2014 ; Dotis et al, 2015 ; Du et al, 2015 ; Zhang et al, 2017 ), particularly in immunocompromised hosts. Though the pathogenicity of such species is known to us to some extent, the relevance to pSS and dental caries remains undetermined.…”

Cellulitis Caused by a Novel Cupriavidus Species Strain J1218 Identified by Whole Genome Sequencing

“…Patients infected with Cupriavidus species are usually immunocompromised [2,3,5,7]. Cases of infection with this genus have also been reported in elderly patients without obvious immunodeficiency [15,16]. The patient in the present study was immunocompetent, but had experienced frequent injuries to the lower limbs.…”

Isolation of a novel species in the genus Cupriavidus from a patient with sepsis using whole genome sequencing

“…Although the pathogenicity of the genus Cupriavidus in human infection is unclear, the evidence of its pathogenicity are growing especially for C. gilardii, the most closely related species to the novel Cupriavidus species isolated in this study. C. gilardii was isolated from the blood, throat, abscess, or stool specimens in immunocompromised patients [1,6,7]. Most patients respond well to antibiotics, but a fatal outcome from septic conditions has also been reported in a child with aplastic anemia [6].…”

“…The genus Cupriavidus belongs to the Gram-negative β-proteobacteria that have been found in human clinical specimens and environmental sources [1,2]. The genus Cupriavidus was first proposed in 1987 by Makkar and Casida, who described Cupriavidus necator: a nonobligate bacterial predator of bacteria in soil [3,4].…”

“…The genus Cupriavidus was first proposed in 1987 by Makkar and Casida, who described Cupriavidus necator: a nonobligate bacterial predator of bacteria in soil [3,4]. Since then, a total of 17 recognized Cupriavidus species have been reported [5], and to date, C. gilardii [1,6,7], C. metallidurans [8], and C. pauculus [9,10] have been isolated from human clinical specimens.…”