First case report of cutaneous sporotrichosis (<i>Sporothrix</i> species) in a cat in the UK

Makri, Nikoleta; Paterson, Gavin K.; Gregge, Fiona; Urquhart, Catriona; Nuttall, Tim

doi:10.1177/2055116920906001

Cited by 17 publications

(19 citation statements)

References 28 publications

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“…Currently, S. brasiliensis, S. schenckii, and Sporothrix humicola are the known causative agents of feline sporotrichosis [19,20,25,[39][40][41][42]. Cases of feline sporotrichosis were reported in the USA, Mexico, Argentina, Paraguay, Malaysia, Spain, Germany, Australia, Japan, Thailand, the UK, and Brazil [3-5, 17, 18, 41, 42].…”

Section: Feline Sporotrichosis Caused By S Brasiliensismentioning

confidence: 99%

Guideline for the management of feline sporotrichosis caused by Sporothrix brasiliensis and literature revision

et al. 2020

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We herein present a Brazilian guideline for the management of feline sporotrichosis, a mycosis caused by Sporothrix brasiliensis. This guideline is an effort of a national technical group organized by the Working Group on Sporothrix and Sporotrichosis of the International Society for Human and Animal Mycology (ISHAM). This publication intends to provide information on clinicalepidemiological aspects of this zoonosis, as well as a literature revision. Moreover, it gives some practical information on diagnosis and treatment of feline sporotrichosis. It also contains information that can be helpful for the prevention and control of S. brasiliensis transmission.

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Section: Feline Sporotrichosis Caused By S Brasiliensismentioning

confidence: 99%

Guideline for the management of feline sporotrichosis caused by Sporothrix brasiliensis and literature revision

et al. 2020

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“…Outside this clinical clade, pathogenicity to mammals is rarely observed, and only a few reports have appeared in the literature of infections by members of the S. pallida and S. stenoceras complexes ( de Beer et al. 2016 , Makri et al. 2020 ) or by relatives in the genus Ophiostoma , e.g.…”

Section: Introductionmentioning

confidence: 99%

Exploring genetic diversity, population structure, and phylogeography in Paracoccidioides species using AFLP markers

Carvalho¹,

Beale²,

Hagen³

et al. 2021

Studies in Mycology

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Sporothrix ( Ophiostomatales ) comprises species that are pathogenic to humans and other mammals as well as environmental fungi. Developments in molecular phylogeny have changed our perceptions about the epidemiology, host-association, and virulence of Sporothrix . The classical agent of sporotrichosis, Sporothrix schenckii , now comprises several species nested in a clinical clade with S. brasiliensis , S. globosa , and S. luriei . To gain a more precise view of outbreaks dynamics, structure, and origin of genetic variation within and among populations of Sporothrix , we applied three sets of discriminatory AFLP markers (#3 EcoRI-GA/MseI-TT, #5 EcoRI-GA/MseI-AG, and #6 EcoRI-TA/MseI-AA) and mating-type analysis to a large collection of human, animal and environmental isolates spanning the major endemic areas. A total of 451 polymorphic loci were amplified in vitro from 188 samples, and revealed high polymorphism information content ( PIC = 0.1765–0.2253), marker index ( MI = 0.0001–0.0002), effective multiplex ratio ( E = 15.1720–23.5591), resolving power ( Rp = 26.1075–40.2795), discriminating power ( D = 0.9766–0.9879), expected heterozygosity ( H = 0.1957–0.2588), and mean heterozygosity ( H avp = 0.000007–0.000009), demonstrating the effectiveness of AFLP markers to speciate Sporothrix . Analysis using the program structure indicated three genetic clusters matching S. brasiliensis (population 1), S. schenckii (population 2), and S. globosa (population 3), with the presence of patterns of admixture amongst all populations. AMOVA revealed highly structured clusters (PhiPT = 0.458–0.484, P < 0.0001), with roughly equivalent genetic variability within (46–48 %) and between (52–54 %) populations. Heterothallism was the exclusive mating strategy, and the distributions of MAT1-1 or MAT1-2 idiomorphs were not significantly skewed (1:1 ratio) for S. schenckii (χ 2 = 2.522; P = 0.1122), supporting random mating. In contrast, skewed distributions were found for S. globosa (χ 2 = 9.529; P = 0.0020) with a predominance of MAT1-1 isolates, and regional differences were highlighted for S. brasiliensis with the overwhelming occurrence of MAT1-2 in Rio de Janeiro (χ 2 = 14.222; P = 0.0002) and Pernambuco (χ 2 ...

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“…Currently, sporotrichosis is especially frequent in Latin America, South Africa, Madagascar, China, India, and Japan [ 3 ], but it can also be observed elsewhere [ 11 ]. In addition to endemic disease, multiple sporotrichosis outbreaks have been reported in the last century [ 2 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

A novel Sporothrix brasiliensis genomic variant in Midwestern Brazil: evidence for an older and wider sporotrichosis epidemic

Filho

Santos

Reis

et al. 2020

Emerging Microbes & Infections

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A novel Sporothrix brasiliensis genomic variant in Midwestern Brazil: evidence for an older and wider sporotrichosis epidemic Sporotrichosis is a subcutaneous infection caused by fungi from the genus Sporothrix. It is transmitted by inoculation of infective particles found in plant-contaminated material or diseased animals, characterizing the classic sapronotic and emerging zoonotic transmission, respectively. Since 1998, southeastern Brazil has experienced a zoonotic sporotrichosis epidemic caused by S. brasiliensis, centered in the state of Rio de Janeiro. Our observation of feline sporotrichosis cases in Brasília (Midwestern Brazil), around 900 km away from Rio de Janeiro, led us to question whether the epidemic caused by S. brasiliensis has spread from the epicenter in Rio de Janeiro, emerged independently in the two locations, or if the disease has been present and unrecognized in Midwestern Brazil. A retrospective analysis of 91 human and 4 animal cases from Brasília, ranging from 1993 to 2018, suggests the occurrence of both sapronotic and zoonotic transmission. Molecular typing of the calmodulin locus identified S. schenckii as the agent in two animals and all seven human patients from which we were able to recover clinical isolates. In two other animals, the disease was caused by S. brasiliensis. Whole-genome sequence typing of seven Sporothrix spp. strains from Brasília and Rio de Janeiro suggests that S. brasiliensis isolates from Brasília are genetically distinct from those obtained at the epicenter of the outbreak in Rio de Janeiro, both in phylogenomic and population genomic analyses. The two S. brasiliensis populations seem to have separated between 2.2 and 3.1 million years ago, indicating independent outbreaks or that the zoonotic S. brasiliensis outbreak might have started earlier and be more widespread in South America than previously recognized.

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First case report of cutaneous sporotrichosis (Sporothrix species) in a cat in the UK

Cited by 17 publications

References 28 publications

Guideline for the management of feline sporotrichosis caused by Sporothrix brasiliensis and literature revision

Guideline for the management of feline sporotrichosis caused by Sporothrix brasiliensis and literature revision

Exploring genetic diversity, population structure, and phylogeography in Paracoccidioides species using AFLP markers

A novel Sporothrix brasiliensis genomic variant in Midwestern Brazil: evidence for an older and wider sporotrichosis epidemic

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