First case of pneumonia caused by Cupriavidus pauculus in an infant in the Gulf Cooperation Council

Yahya, Raghda; Alyousef, Wafaa; Omara, Abdelwahab; Alamoudi, Suha; Alshami, Alanoud; Abdalhamid, Baha

doi:10.3855/jidc.8349

Cited by 9 publications

(10 citation statements)

References 8 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From intestinal studies, we know that the genus Elizabethkingia sp. is present in the mucosa of ulcerative colitis (UC) patients and significantly higher in exacerbated UC [43]. In our infant samples, we found an increased abundance of this genus in the mucosa compared to the lumen.…”

Section: Discussionmentioning

confidence: 61%

“…and Cupriavidus sp. are overlapping genera known as environmental Gram-negative bacteria belonging to the class Betaproteobacteria of low virulence, rarely causing infections in nonimmunosuppressed humans [42,43]. Nevertheless, the gastrointestinal tract of neonates suffering from necrotizing enterocolitis was already described in a study by Smith et al in 2011 to be colonized with Ralstonia sp.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Characterization of the Luminal and Mucosa-Associated Microbiome along the Gastrointestinal Tract: Results from Surgically Treated Preterm Infants and a Murine Model

et al. 2021

View full text Add to dashboard Cite

Environmental factors, including nutritional habits or birth mode, are known key determinants for intestinal microbial composition. Investigations of the intestinal microbiome in different species in a multiplicity of studies during recent decades have revealed differential microbial patterns and quantities along the gastrointestinal (GI) tract. Characterization of the microbial pattern in various aspects is a prerequisite for nutritional interventions. In this 16S rRNA amplicon-based approach, we present a characterization of the mucosa-associated microbiome in comparison with the luminal community of four infants at the time of the closure of ileostomies and perform a systematic characterization of the corresponding luminal and mucosal microbiome from jejunal, ileal and colonic regions, as well as collected feces in mice. The most dominant taxa in infant-derived samples altered due to individual differences, and in the mucosa, Enterococcus, Clostridiumsensustricto1, Veillonella, Streptococcus and Staphylococcus were the most abundant. Two less abundant taxa differed significantly between the mucosa and lumen. In murine samples, relative abundances differed significantly, mainly between the intestinal regions. Significant differences between mouse mucosa- and lumen-derived samples could be found in the observed species with a trend to lower estimated diversity in mucosa-derived samples, as well as in the relative abundance of individual taxa. In this study, we examined the difference between the mucosal and luminal bacterial colonization of the gastrointestinal tract in a small sample cohort of preterm infants. Individual differences were characterized and statistical significance was reached in two taxa (Cupriavidus, Ralstonia). The corresponding study on the different murine intestinal regions along the GI tract showed differences all over the intestinal region.

show abstract

Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Characterization of the Luminal and Mucosa-Associated Microbiome along the Gastrointestinal Tract: Results from Surgically Treated Preterm Infants and a Murine Model

et al. 2021

View full text Add to dashboard Cite

show abstract

“…It has been implicated in pseudo-outbreaks of skin and superficial site infections. It is believed to cause nosocomial infections by the contamination of nebulization solution, ultrafiltrate water, thermos-regulator reservoir water, extracorporeal membrane oxygenation system (ECMO), tap water, hydrotherapy pools, and bottled mineral water [9][10][11]. It causes infection in predominantly immunocompromised hosts, especially in hematological malignancies and hematopoietic stem cell transplant (HSCT) patients.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Ventilator-Associated Pneumonia Caused by Cupriavidus Pauculus

Huda

Yadava

Kahlown

et al. 2020

Cureus

View full text Add to dashboard Cite

show abstract

“…The genus Cupriavidus was first proposed in 1987 by Makkar and Casida, who described Cupriavidus necator: a nonobligate bacterial predator of bacteria in soil [3,4]. Since then, a total of 17 recognized Cupriavidus species have been reported [5], and to date, C. gilardii [1,6,7], C. metallidurans [8], and C. pauculus [9,10] have been isolated from human clinical specimens.…”

Section: Introductionmentioning

confidence: 99%

Isolation of a novel species in the genus Cupriavidus from a patient with sepsis using whole genome sequencing

et al. 2020

View full text Add to dashboard Cite

Whole genome sequencing (WGS) has become an accessible tool in clinical microbiology, and it allowed us to identify a novel Cupriavidus species. We isolated Gram-negative bacillus from the blood of an immunocompromised patient, and phenotypical and molecular identifications were performed. Phenotypic identification discrepancies were noted between the Vitek 2 (bioMé rieux, Marcy-l'É toile, France) and Vitek MS systems (bioMé rieux). Using 16S rRNA gene sequencing, it was impossible to identify the pathogen to the species levels. WGS was performed using the Illumina MiSeq platform (Illumina, San Diego, CA), and genomic sequence database searching with a TrueBac TM ID-Genome system (ChunLab, Inc., Seoul, Republic of Korea) showed no strains with average nucleotide identity values higher than 95.0%, which is the cutoff for species-level identification. Phylogenetic analysis indicated that the bacteria was a new Cupriavidus species that formed a subcluster with Cupriavidus gilardii. WGS holds great promise for accurate molecular identification beyond 16S rRNA gene sequencing in clinical microbiology.

show abstract

First case of pneumonia caused by Cupriavidus pauculus in an infant in the Gulf Cooperation Council

Cited by 9 publications

References 8 publications

Characterization of the Luminal and Mucosa-Associated Microbiome along the Gastrointestinal Tract: Results from Surgically Treated Preterm Infants and a Murine Model

Characterization of the Luminal and Mucosa-Associated Microbiome along the Gastrointestinal Tract: Results from Surgically Treated Preterm Infants and a Murine Model

A Rare Case of Ventilator-Associated Pneumonia Caused by Cupriavidus Pauculus

Isolation of a novel species in the genus Cupriavidus from a patient with sepsis using whole genome sequencing

Contact Info

Product

Resources

About