First case of penile metastasis following abdominoperineal resection with VRAM flap reconstruction

Kozan, Andrei Adrian; Smith, Andrew B. T.; Ilsley, David W.; Rhodes, Nicholas G.

doi:10.1093/jscr/rjw182

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…The mass usually progresses to involve the corpora cavernosa with extension into the corpus spongiosum, bulb, and neighboring perineal subcutaneous tissue. [ 6 ] Penile metastasis should be distinguished from primary penile cancer, chancre, primary syphilis, condyloma acuminate, tuberculosis, Peyronie's disease, and other inflammatory diseases. [ 13 ] To confirm the diagnosis of penile metastasis, immunhistochemical staining can be helpful for discrimination of the origin of primary cancer.…”

Section: Discussionmentioning

confidence: 99%

Penile metastasis in rectal cancer with pathologic complete response after neoadjuvant chemoradiotherapy

Lee¹,

Son

Kim³

et al. 2020

Medicine

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Rationale: Penile metastasis in rectal cancer is very rare and often originates from prostatic or bladder cancer. The prognosis of penile metastasis is poor and its treatments are more often palliative than curative due to association with disseminated metastases. Pathologic complete response (pCR) in rectal cancer with neoadjuvant chemoradiotherapy (CRT) has been shown to be surrogate marker of favorable long-term outcomes and currently has no report of penile metastasis. Here, we first report isolated penile metastasis in rectal cancer with pCR after neoadjuvant CRT. Patient concern: The patient was a 74-year-old male with metastasis to the glans penis from rectal cancer diagnosed 9 months after abdominoperineal resection. Physical examination revealed palpable multiple nodules on the glans penis. Diagnosis: Penile biopsy revealed metastatic carcinoma from the rectal cancer. Intervention: Chemotherapy was started as soon as possible, because patient suffered urinary discomfort by rapid growing metastatic lesions. He is currently receiving palliative chemotherapy with modified FOLFOX-6 (mFOLFOX-6; oxaliplatin with 5-fluorouracil and folinic acid) plus bevacizumab. Outcome: The patient is still alive 4 months after diagnosis with markedly decreased metastatic lesions. Lesson: We propose that although penile metastasis in rectal cancer with pCR after preoperative neoadjuvant CRT is extremely rare, it might help to start early palliative chemotherapy and clinicians should be aware of this possibility.

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Section: Discussionmentioning

confidence: 99%

Penile metastasis in rectal cancer with pathologic complete response after neoadjuvant chemoradiotherapy

Lee¹,

Son

Kim³

et al. 2020

Medicine

View full text Add to dashboard Cite

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“…[8] The most common sites of metastases are lung/pleura, somatic soft tissue, lymph nodes, liver and bone. [6,8] Penile metastases from a cancer is rare however it has been previously reported in the literature from the colorectal cancer, [9] prostate cancer, genitourinary tract, osteosarcoma and cholangiocarcinoma. [10] In our case there were multiple metastases including penile involvement.…”

Section: Discussionmentioning

confidence: 99%

A case report of a renal liposarcoma with penile metastases

Turner

Tiwari

Gunaratne³

et al. 2017

IJDI

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A 73-year-old man presented to his general practitioner with a left sided abdominal mass, intermittent night sweats and left sided sciatic pain on movement. A computed tomography (CT) scan revealed a well encapsulated mass arising from the left kidney, measuring 180 mm × 150 mm. Following an open nephrectomy, the tumour was confirmed as being Trojani Grade II dedifferentiated liposarcoma. Repeat CTs at four months and one-year post-surgery were clear of metastases, but after 17 months the patient presented in the emergency department with severe right-sided flank pain. A CT scan showed evidence of metastatic recurrence in the lungs, sternum and right quadratus lumborum muscle. The patient was treated with palliative radiotherapy and a repeat CT taken to assess the rate of disease progression showed a new metastatic deposit within the right penile corpus cavernosum.

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Surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy of rectal adenocarcinoma with penile metastasis: a case report

Wang¹,

Shan²,

Zhou³

et al. 2023

J Gastrointest Oncol

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Background Despite the rich proximity and vascularization to the pelvic organs, metastatic lesions to the penis are incredibly uncommon. Most primary tumors are genitourinary cancers, and rectal origins are rare. Only 56 cases of metastatic penile tumors have been reported since 1870. Several palliative or curative methods, such as chemotherapy, total penectomy, and radiotherapy, have been applied to treat this condition in previous cases; however, the patient prognosis is poor. Immunotherapy is a beneficial treatment approach for multiple cancers, and recent investigations have shown that it may be beneficial for patients with advanced penile cancer. Case Description Herein, we report the case of a 59-year-old Chinese man who had metastatic adenocarcinoma in the penile tissue 3 years after rectal cancer resection. The patient presented with penile pain and dysuria for 6 months when he was 54 years old, and Immunohistochemical staining showed that the origin was the rectum after total penectomy. The patient received surgery, chemotherapy, radiotherapy, targeted therapy and immunotherapy positively and still survived for a further 4 years and 6 months following penectomy despite the late metastasis of rectal cancer. There are two major changes and progress after penectomy, all of which have undergone surgical treatment during continuous treatment and follow-up, the patient completed right inguinal lymphadenectomy when his right regional nodes metastasis was found 23 months after penectomy. While the patient suffered from radiation injury after 47 months after penectomy, which led to radiation necrosis and hip soft tissue infection, and the patient tended to lay prone instead of lying on the back because of the hip pain. The patient ultimately died of multiple organ failure. Conclusions All of the previously reported cases of penile metastasis from rectal cancer since 1870 have been reviewed. Yet, the metastatic prognosis remains poor regardless of the treatment options, except for lesions where metastasis is only limited to the penis. We found that the patient may derive more benefit from strategic therapies including surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy.

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First case of penile metastasis following abdominoperineal resection with VRAM flap reconstruction

Cited by 4 publications

References 6 publications

Penile metastasis in rectal cancer with pathologic complete response after neoadjuvant chemoradiotherapy

Penile metastasis in rectal cancer with pathologic complete response after neoadjuvant chemoradiotherapy

A case report of a renal liposarcoma with penile metastases

Surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy of rectal adenocarcinoma with penile metastasis: a case report

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