First case of Nocardia nova spinal abscess in an immunocompetent patient

Hong, Seung Bok; Han, Kyudong; Son, Bo Ra; Shin, Kyeong Seob; Rim, Byeong Cheol

doi:10.1590/s1413-86702012000200017

Cited by 2 publications

(3 citation statements)

References 18 publications

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“…Two of these case reports referred to the same case, and thus were combined for the purpose of this review. An additional four case reports were identified among the references cited by those 22 cases, to bring the total number of cases reviewed to 26 . Among these 26 cases (summarized in Table ), 46% of patients had spinal epidural abscesses, 42% had intramedullary abscesses, and 12% had both.…”

Section: Discussionmentioning

confidence: 99%

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An unusual case of Nocardia cyriacigeorgica presenting with spinal abscesses in a renal transplant recipient and a review of the literature

Freiberg

Saharia

Morales

2018

Transplant Infectious Dis

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Nocardia species represent a well-recognized yet uncommon cause of opportunistic infections in humans. It most frequently presents as a pulmonary infection with or without central nervous system involvement. It is a very rare cause of spinal abscesses, with only 26 cases reported in the literature. Here, we report a 49-year-old man with a history of renal transplantation who presented with low back pain and was diagnosed with epidural and paraspinal abscesses due to Nocardia cyriacigeorgica that was successfully treated with antimicrobial therapy alone. In addition to the case reported here, we also conducted a systematic review of the existing literature regarding spinal abscesses due to Nocardia species and examined the success of the various treatments utilized. K E Y W O R D S Nocardia, Nocardia cyriacigeorgica, nocardiosis, renal transplant, spinal abscess How to cite this article: Freiberg JA, Saharia KK, Morales MK. An unusual case of Nocardia cyriacigeorgica presenting with spinal abscesses in a renal transplant recipient and a review of the literature. Transpl Infect Dis. 2019;21:e13025. https://doi.

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Section: Discussionmentioning

confidence: 99%

“…Only two cases (9%) involved monotherapy with a long course of TMP/SMX alone following surgical intervention . For the three cases in which a sulfonamide was not used, TMP/SMX use was discontinued due to allergic reactions in two of the cases, while the antibiotic choice was not explained in the other …”

Section: Discussionmentioning

confidence: 99%

An unusual case of Nocardia cyriacigeorgica presenting with spinal abscesses in a renal transplant recipient and a review of the literature

Freiberg

Saharia

Morales

2018

Transplant Infectious Dis

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“…[27,28] . In the case of complex taxonomic groups, the confirmation of the identification was done using specific primers; rec A gene for the isolates belonging to the Burkholderia cepacia complex [29]; rpo B gene for Corynebacterium species [30] and sec A gene on the Actinomycetales isolates [31].…”

Section: Methodsmentioning

confidence: 99%

Utility of platforms Viteks MS and Microflex LT for the identification of complex clinical isolates that require molecular methods for their taxonomic classification

et al. 2019

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Mass spectrometry has revolutionized the clinical microbiology field in America’s and Europe’s industrialized countries, for being a fast, reliable and inexpensive technique. Our study is based on the comparison of the performance of two commercial platforms, Microflex LT (Bruker Daltonics, Bremen, Germany) and Vitek MS (bioMérieux, Marcy l´Etoile, France) for the identification of unusual and hard-to-diagnose microorganisms in a Reference Laboratory in Argentina. During a four-month period (February–May 2018) the diagnostic efficiency and the concordance between both systems were assessed, and the results were compared with the polyphasic taxonomic identification of all isolates. The study included 265 isolates: 77 Gram-Negative Bacilli, 33 Gram-Positive Cocci, 40 Anaerobes, 35 Actinomycetales, 19 Fastidious Microorganisms and 61 Gram-Positive Bacilli. All procedures were practiced according to the manufacturer’s recommendations in each case by duplicate, and strictly in parallel. Other relevant factors, such as the utility of the recommended extraction protocols, reagent stability and connectivity were also evaluated. Both systems correctly identified the majority of the isolates to species and complex level (82%, 217/265) . Vitex MS achieved a higher number of correct species-level identifications between the gram-positive microorganisms; however, it presented greater difficulty in the identification of non-fermenting bacilli and a higher number of incorrect identifications when the profile of the microorganism was not represented in the commercial database. Both platforms showed an excellent performance on the identification of anaerobic bacteria and fastidious species. Both systems enabled the fast and reliable identification of most of the tested isolates and were shown to be very practical for the user.

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First case of Nocardia nova spinal abscess in an immunocompetent patient

Cited by 2 publications

References 18 publications

An unusual case of Nocardia cyriacigeorgica presenting with spinal abscesses in a renal transplant recipient and a review of the literature

An unusual case of Nocardia cyriacigeorgica presenting with spinal abscesses in a renal transplant recipient and a review of the literature

Utility of platforms Viteks MS and Microflex LT for the identification of complex clinical isolates that require molecular methods for their taxonomic classification

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