First case of Legionnaires’ disease caused by Legionella pneumophila ST59 strain in China

Ma, Yanliang; Qin, Tian; Ren, Hao; Zhou, Haijian; Gong, Pihua; Bao, Jing; Gao, Zhancheng

doi:10.1097/mrm.0000000000000002

Cited by 1 publication

(1 citation statement)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After querying the SBT database, we found five STs (ST1, ST59, ST60, ST345, ST595) that had previously caused Legionnaires’ diseases worldwide. In our previous study, we reported a Legionnaires’ disease that was caused by a L. pneumophila strain of ST59, which was the second predominant ST in this study [ 32 ]. ST1, which is the most prevalent ST worldwide [ 33 , 34 , 35 , 36 , 37 , 38 , 39 ], was the most predominant ST in this study.…”

Section: Discussionmentioning

confidence: 87%

Prevalence and Molecular Characteristics of Waterborne Pathogen Legionella in Industrial Cooling Tower Environments

Qin

et al. 2015

IJERPH

Self Cite

View full text Add to dashboard Cite

Cooling towers are a source of Legionnaires’ disease. It is important from a public health perspective to survey industrial cooling towers for the presence of Legionella. Prospective surveillance of the extent of Legionella pollution was conducted at factories in Shijiazhuang, China between March 2011 and September 2012. Overall, 35.7% of 255 industrial cooling tower water samples showed Legionella-positive, and their concentrations ranged from 100 Colony-Forming Units (CFU)/liter to 88,000 CFU/liter, with an average concentration of 9100 CFU/liter. A total of 121 isolates were obtained. All isolates were L. pneumophila, and the isolated serogroups included serogroups 1 (68 isolates, 56.2%), 6 (25, 20.7%), 5 (12, 9.9%), 8 (8, 6.6%), 3 (6, 5.0%) and 9 (2, 1.6%). All 121 isolates were analyzed by pulsed-field gel electrophoresis (PFGE) and 64 different patterns were obtained. All 121 isolates were analyzed sequence-based typing (SBT), a full 7-allele profile was obtained from 117 isolates. One hundred and seventeen isolates were divided into 49 sequence types. Two virulence genes, lvh and rtxA, are analyzed by polymerase chain reaction (PCR). 92.6% (112/121) and 98.3% (119/121) isolates carried lvh and rtxA respectively and 90.9% (110/121) of tested isolates carried both genes. Our results demonstrated high prevalence and genetic polymorphism of L. pneumophila in industrial cooling tower environments in Shijiazhang, China, and the SBT and virulence gene PCR results suggested that the isolates were pathogenic. Improved control and prevention strategies are urgently needed.

show abstract