First case of Kerstersia gyiorum isolated from a patient with chronic osteomyelitis in China

Lan, You; Yan, Qun; Yan, Yuying; Liu, Wenen

doi:10.1016/j.flm.2017.08.003

Cited by 3 publications

(5 citation statements)

References 7 publications

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“…Pedobacter glucosidilyticus was also enriched by culturing C. pyrenoidosa , whereas Kerstersia gyiorum , MNG7 and Saprospiraceae were suppressed. K. gyiorum is a pathogenic member of the family Alcaligenaceae and is commonly isolated from leg wounds, chronic ear infections, human feces, sputum, and even bronchoalveolar lavage fluids and the urinary tract [39–41]. The suppression of pathogenic microbes by C. pyrenoidosa might contribute to a decrease in the risk to public health.…”

Section: Resultsmentioning

confidence: 99%

Comprehensive evaluation of a cost-effective method of culturing Chlorella pyrenoidosa with unsterilized piggery wastewater for biofuel production

Zhang

et al. 2019

Biotechnol Biofuels

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Background The utilization of Chlorella for the dual goals of biofuel production and wastewater nutrient removal is highly attractive. Moreover, this technology combined with flue gas (rich in CO 2 ) cleaning is considered to be an effective way of improving biofuel production. However, the sterilization of wastewater is an energy-consuming step. This study aimed to comprehensively evaluate a cost-effective method of culturing Chlorella pyrenoidosa in unsterilized piggery wastewater for biofuel production by sparging air or simulated flue gas, including algal biomass production, lipid production, nutrient removal rate and the mutual effects between algae and other microbes. Results The average biomass productivity of C. pyrenoidosa reached 0.11 g L −1 day −1 /0.15 g L −1 day −1 and the average lipid productivity reached 19.3 mg L −1 day −1 /30.0 mg L −1 day −1 when sparging air or simulated flue gas, respectively. This method achieved fairish nutrient removal efficiency with respect to chemical oxygen demand (43.9%/55.1% when sparging air and simulated flue gas, respectively), ammonia (98.7%/100% when sparging air and simulated flue gas, respectively), total nitrogen (38.6%/51.9% when sparging air or simulated flue gas, respectively) and total phosphorus (42.8%/60.5% when sparging air or simulated flue gas, respectively). Culturing C. pyrenoidosa strongly influenced the microbial community in piggery wastewater. In particular, culturing C. pyrenoidosa enriched the abundance of the obligate parasite Vampirovibrionales, which can result in the death of Chlorella . Conclusion The study provided a comprehensive evaluation of culturing C. pyrenoidosa in unsterilized piggery wastewater for biofuel production. The results indicated that this cost-effective method is feasible but has considerable room for improving. More importantly, this study elucidated the mutual effects between algae and other microbes. In particular, a detrimental effect of the obligate parasite Vampirovibrionales on algal biomass and lipid production was found. Electronic supplementary material The online version of this article (10.1186/s13068-019-1407-x) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Comprehensive evaluation of a cost-effective method of culturing Chlorella pyrenoidosa with unsterilized piggery wastewater for biofuel production

Zhang

et al. 2019

Biotechnol Biofuels

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“… 19 Most previous reports used cephalosporins or fluoroquinolones for the treatment of K. gyiorum infections, such as ceftriaxone and ciprofloxacin. 13 , 20 , 21 The antibiotics used for treatment of some patients with severe mixed infection varied in previous reports and comprised piperacillin/tazobactam, 22 , 23 ampicillin/sulbactam, 2 imipenem, 24 or meropenem 14 ( Table 2 ). Among the previously reported cases with mixed infections, multiple species were identified, including Enterobacteriaceae , non-fermenting Gram-negative bacilli , Staphylococcus aureus, and diphtheroids.…”

Section: Discussionmentioning

confidence: 99%

“…Since K. gyiorum was named, it has been reported in various diseases, such as chronic ear infection, 2 chronic lower limb infection, 12 hemorrhagic dermatitis, 14 chronic venous insufficiency, 17 respiratory tract infection, 27 urinary tract infection, 28 thromboangiitis obliterans, 21 and chronic osteomyelitis 23 ( Table 2 ). K. gyiorum mainly causes chronic ear and leg infections, the pathogenic mechanism of which remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Kerstersia gyiorum isolated for the first time from two patients with neurodegenerative disease: report of two unusual cases and a review of the literature

et al. 2023

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With the development of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and 16S ribosomal RNA (rRNA) gene sequencing, increasing numbers of new microorganisms are being discovered. In this report, Kerstersia gyiorum was isolated for the first time from the sputum of two elderly patients with neurodegenerative disease, and integrated traditional Chinese and Western medicine was used for treatment. The bacteria’s growth characteristics, biochemical reaction characteristics, sensitivity to antibiotics, and the patients’ treatment are described, with a review of previous reports.

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“…Additionally, K . gyiorum was also reported to be isolated from patients with chronic tracheostomy [3], chronic osteomyelitis [12], or urinary tract infection [9]. In fact, it is difficult to distinguish K .…”

Section: Introductionmentioning

confidence: 99%

“…gyiorum from other microorganisms using conventional methods, such as traditional biochemical tests and automated identification systems, which may lead to K . gyiorum being identified incorrectly or unsuccessfully in the past in most clinical laboratories [12]. The potentially clinical importance of K .…”

Section: Introductionmentioning

confidence: 99%

Genomic characterization of Kerstersia gyiorum SWMUKG01, an isolate from a patient with respiratory infection in China

et al. 2019

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Background The Gram-negative bacterium Kerstersia gyiorum , a potential etiological agent of clinical infections, was isolated from several human patients presenting clinical symptoms. Its significance as a possible pathogen has been previously overlooked as no disease has thus far been definitively associated with this bacterium. To better understand how the organism contributes to the infectious disease, we determined the complete genomic sequence of K . gyiorum SWMUKG01, the first clinical isolate from southwest China. Results The genomic data obtained displayed a single circular chromosome of 3, 945, 801 base pairs in length, which contains 3, 441 protein-coding genes, 55 tRNA genes and 9 rRNA genes. Analysis on the full spectrum of protein coding genes for cellular structures, two-component regulatory systems and iron uptake pathways that may be important for the success of the bacterial survival, colonization and establishment in the host conferred new insights into the virulence characteristics of K . gyiorum . Phylogenomic comparisons with Alcaligenaceae species indicated that K . gyiorum SWMUKG01 had a close evolutionary relationships with Alcaligenes aquatilis and Alcaligenes faecalis . Conclusions The comprehensive analysis presented in this work determinates for the first time a complete genome sequence of K . gyiorum , which is expected to provide useful information for subsequent studies on pathogenesis of this species.

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First case of Kerstersia gyiorum isolated from a patient with chronic osteomyelitis in China

Cited by 3 publications

References 7 publications

Comprehensive evaluation of a cost-effective method of culturing Chlorella pyrenoidosa with unsterilized piggery wastewater for biofuel production

Comprehensive evaluation of a cost-effective method of culturing Chlorella pyrenoidosa with unsterilized piggery wastewater for biofuel production

Kerstersia gyiorum isolated for the first time from two patients with neurodegenerative disease: report of two unusual cases and a review of the literature

Genomic characterization of Kerstersia gyiorum SWMUKG01, an isolate from a patient with respiratory infection in China

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