First Case of Dendriform Pulmonary Ossification in Bahrain

Naser, Naser; Alwedaie, Sayed Mohammed Jawad; Kadhem, Husain

doi:10.7759/cureus.12904

Cited by 2 publications

(4 citation statements)

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“…Other secondary cases of DPO were observed in patients in their 60s–80s 32 33. However, recent reports have shown that IDPO diagnosed by surgical lung biopsy was distributed among patients in their 20s–40s 16–18 25–29. In our study, the diagnosis was made in 5 patients in their 20s and 8 patients in their 30s.…”

Section: Discussioncontrasting

confidence: 59%

“…In addition, we did not ask the occupational exposure in detail, and did not extensively investigate the biomarkers including autoimmune markers. Although IDPO cases were often reported from Japan, some has been diagnosed in other countries such as Canada, 11 UK, 14 China, 16 Bahrain 17 and USA, 33 indicating that IDPO would be distributed worldwide.…”

Section: Discussionmentioning

confidence: 99%

“…9 In the 2000s, several cases of idiopathic cases of pulmonary ossification in the absence of underlying pulmonary or systemic diseases were reported. [10][11][12][13][14][15][16][17][18] The information from these reports indicates the homogenous clinical features such as male-predominance, asymptomatic disease and branching-type ossification on HRCT scans and/or histological findings, but, to our knowledge, there is no comprehensive study on the clinical features including onset, pulmonary function, complications, clinical course, biomarkers and prognosis, in addition to radiological and histopathological details.…”

Section: What This Study Addsmentioning

confidence: 99%

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Nationwide retrospective observational study of idiopathic dendriform pulmonary ossification: clinical features with a progressive phenotype

et al. 2022

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BackgroundDiffuse pulmonary ossification is a specific lung condition that is accompanied by underlying diseases. However, idiopathic dendriform pulmonary ossification (IDPO) is extremely rare, and the clinical features remain unclear. In this study, we aimed to report the clinical characteristics of IDPO.MethodsWe conducted a nationwide survey of patients with IDPO from 2017 to 2019 in Japan and evaluated the clinical, radiological, and histopathological findings of patients diagnosed with IDPO.ResultsTwenty-two cases of IDPO were identified. Most subjects (82%) were male, aged 22–56 years (mean (SD), 37.9 (9.1)) at diagnosis. Nearly 80% of the subjects were asymptomatic, and the condition was discovered during a medical check-up. However, 36% of the subjects showed a decline in forced vital capacity (%FVC) predicted <80% at diagnosis. The typical radiological features of high-resolution CT (HRCT) are calcified branching structures that are predominantly distributed in the lower lung fields without any other conspicuous finding. Histopathological analysis also showed dendriform ossified lesions from the intraluminal areas to interstitial areas. Notably, during the follow-up period of 20 years, disease progression was found in 88% on HRCT and more than 50% on pulmonary function tests (FVC and/or forced expiratory volume in 1 s). Two cases with rapid decline of 10% /year in %FVC predicted were observed.)) at diagnosis. Nearly 80% of the subjects were asymptomatic, and the condition was discovered during a medical check-up. However, 36% of the subjects showed a decline in forced vital capacity (%FVC) predicted <80% at diagnosis. The typical radiological features of high-resolution CT (HRCT) are calcified branching structures that are predominantly distributed in the lower lung fields without any other conspicuous finding. Histopathological analysis also showed dendriform ossified lesions from the intraluminal areas to interstitial areas. Notably, during the follow-up period of 20 years, disease progression was found in 88% on HRCT and more than 50% on pulmonary function tests (FVC and/or forced expiratory volume in 1 s). Two cases with rapid decline of 10% /year in %FVC predicted were observed.ConclusionsIDPO develops at a young age with gradually progressive phenotype. Further research and long-term (>20 years) follow-up are required to clarify the pathogenesis and clinical findings in IDPO.

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Section: Discussioncontrasting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: What This Study Addsmentioning

confidence: 99%

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Nationwide retrospective observational study of idiopathic dendriform pulmonary ossification: clinical features with a progressive phenotype

et al. 2022

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“…4,5 Four cases were diagnosed by SLB because these patients could not be definitively diagnosed by TBLB. 2,[6][7][8] Thus, the diagnostic accuracy of TBLB for DPO, as well as in other interstitial lung diseases, may be controversial.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic dendriform pulmonary ossification diagnosed by bronchoscopic lung cryobiopsy: A case report

Sekimoto

Nagata

Kato

et al. 2021

Respirology Case Reports

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Dendriform pulmonary ossification (DPO) is a rare condition characterized by heterotopic bone production of unknown origin within the pulmonary tissue. Many cases are asymptomatic with slow progression and are often diagnosed incidentally during autopsy. Thus, only few cases are diagnosed while the patient is still alive since surgical lung biopsy is often needed for pathological diagnosis. This is the case of a 37-yearold man treated at our hospital due to abnormal findings on chest x-ray without any symptoms. His high-resolution computed tomography revealed diffuse reticular shadows and micronodules, consistent with calcification. He underwent transbronchial lung cryobiopsy (TBLC) and was diagnosed with idiopathic DPO based on pathological findings. To our knowledge, this is the first reported case of DPO diagnosed using TBLC. TBLC can be a useful yet minimally invasive diagnostic tool to diagnose DPO and other interstitial lung diseases.

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First Case of Dendriform Pulmonary Ossification in Bahrain

Cited by 2 publications

References 20 publications

Nationwide retrospective observational study of idiopathic dendriform pulmonary ossification: clinical features with a progressive phenotype

Nationwide retrospective observational study of idiopathic dendriform pulmonary ossification: clinical features with a progressive phenotype

Idiopathic dendriform pulmonary ossification diagnosed by bronchoscopic lung cryobiopsy: A case report

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