First case of chronic wasting disease in Europe in a Norwegian free-ranging reindeer

Benestad, Sylvie L.; Mitchell, Gordon; Simmons, Marion; Ytrehus, Bjørnar; Vikøren, Turid

doi:10.1186/s13567-016-0375-4

Cited by 266 publications

(282 citation statements)

References 30 publications

(32 reference statements)

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“…Décrite pour la première fois en 1967 dans l'état du Colorado, elle n'a cessé depuis de s'étendre dans toute l'Amérique du Nord et a été exportée en Corée du Sud. Pour la première fois en Europe, six cas ont été notifiés en Norvège en 2016, chez le cerf et l'élan (Benestad et al, 2016). Au regard de la prolifération incontrôlée de la maladie sur le continent américain, à même de menacer la survie de certaines espèces de cervidés, cette soudaine et inattendue émergence de la MDC en Europe s'avère particulièrement préoccupante.…”

Section: Risques Associés Aux Maladies à Prions Animalesunclassified

“…Au moins deux types différents ont été décrits après transmission d'isolats américains à des souris transgéniques pour la PrP de Wapiti (Angers et al, 2010). Les cas récemment diagnostiqués en Norvège semblent associés à des souches différentes, du fait d'un profil électrophorétique de la PrP Sc cérébral différent, d'une prolifération restreinte des prions dans le tissu lymphoïde et d'une atteinte préférentielle des élans (Benestad et al, 2016). Le risque de transmission de la MDC aux animaux d'élevage et à l'homme au contact de cervidés infectés reste à préciser, au regard notamment de la diversité de souche et d'espèces infectés.…”

Section: Risques Associés Aux Maladies à Prions Animalesunclassified

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Les prions, agents d’encéphalopathies transmissibles chez les mammifères

Béringue¹

2017

bavf

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Les maladies à prion sont des affections neurodégénératives d'issue fatale touchant principalement les ruminants d'élevage et l'homme. Les prions sont des agents infectieux constitués d'une protéine de l'hôte, la PrP qui, sous sa forme pathologique, s'agrège en polymères de type amyloïde autopropagés. Bien que totalement dépourvus de génome, les prions montrent des propriétés analogues à celles d'autres agents infectieux, dont la diversité de souche, le tropisme tissulaire et la capacité à franchir les barrières de transmission interspécifique. Le but de cette revue est de faire une synthèse des connaissances et des avancées récentes dans ce domaine complexe.

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Section: Risques Associés Aux Maladies à Prions Animalesunclassified

Les prions, agents d’encéphalopathies transmissibles chez les mammifères

Béringue¹

2017

bavf

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“…The first case of CWD in a free-ranging Norwegian reindeer was discovered in the central region of Norway in March of 2016 (Benestad et al, 2016); subsequently, two additional cases in wild deer were discovered in the same area. Norway has decided to use hunters and sharpshooter to eradicate the entire herd of 2,000 animals in this area.…”

Section: Note Added In Proofmentioning

confidence: 99%

Challenges in managing the risks of chronic wasting disease

Leiss

Westphal

Tyshenko

et al. 2017

IJGENVI

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This article summarises efforts at disease surveillance and risk management of chronic wasting disease (CWD). CWD is a fatal neurodegenerative disease of cervids and is considered to be one of the most contagious of the transmissible spongiform encephalopathies (TSEs). Evidence has demonstrated a strong species barrier to CWD for both human and farm animals other than cervids. CWD is now endemic in many US states and two Canadian provinces. Past management strategies of selective culling, herd reduction, and hunter surveillance have shown limited effectiveness. The initial strategy of disease eradication has been abandoned in favour of disease control. CWD continues to spread geographically in North American and risk management is complicated by the presence of the disease in both wild (free-ranging) and captive (farmed) cervid populations. The article concludes that further evaluation by risk managers is required for optimal, cost-effective strategies for aggressive disease control.

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“…Chronic wasting disease (CWD) is a naturally occurring transmissible spongiform encephalopathy (TSE) known to affect a range of cervid species, including white-tailed and mule deer, North American elk (wapiti), moose, and reindeer (1)(2)(3). Since its initial discovery nearly 50 years ago in northern Colorado and southern Wyoming, the disease has been reported in 22 additional states, 2 Canadian provinces, South Korea, and very recently in Norway.…”

Section: Background and Introductionmentioning

confidence: 99%

Chronic Wasting Disease: Evolution of Diagnostic Testing for a Naturally Occurring Prion Disease

Nj¹,

Ja²

2017

Preprint

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Since chronic wasting disease (CWD) was first identified nearly 50 years ago in a captive mule deer herd in the Rocky Mountains of the United States, it has slowly spread across North America through the natural and anthropogenic movement of cervids and their carcasses. As the endemic areas have expanded, so has the need for rapid, sensitive, and cost effective diagnostic tests -especially those which take advantage of samples collected antemortem. Over the past two decades, strategies have evolved from the recognition of microscopic spongiform pathology and associated immunohistochemical staining of the misfolded prion protein to enzyme-linked immunoassays capable of detecting the abnormal prion conformer in postmortem samples. In a history that parallels the diagnosis of more conventional infectious agents, both qualitative and real-time amplification assays have recently been developed to detect minute quantities of misfolded prions in a range of biological and environmental samples. With these more sensitive and semi-quantitative approaches has come a greater understanding of the pathogenesis and epidemiology of this disease in the native host. Because the molecular pathogenesis of prion Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted:

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First case of chronic wasting disease in Europe in a Norwegian free-ranging reindeer

Cited by 266 publications

References 30 publications

Les prions, agents d’encéphalopathies transmissibles chez les mammifères

Les prions, agents d’encéphalopathies transmissibles chez les mammifères

Challenges in managing the risks of chronic wasting disease

Chronic Wasting Disease: Evolution of Diagnostic Testing for a Naturally Occurring Prion Disease

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