First case of Chlorella wound infection in a human in Australia

Hart, Jane; Mooney, Lewis R.; Arthur, Ian; Inglis, Tim; Murray, Ronan J.

doi:10.1002/nmi2.50

Cited by 9 publications

(3 citation statements)

References 8 publications

(11 reference statements)

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“…Chlorella is unicellular algae of the Family Chlorellaceae and are found in fresh water, salt water and soil. [ 142 ] Chlorella possesses abundant nutrition such as proteins, lipids, nucleic acid and vitamins, and has been named as “green healthy food” by the Food and Agriculture Organization of the United Nations. [ 143 ] Importantly, Chlorella is a facultative aerobic organism that can use solar energy to synthesize biohydrogen under anaerobic conditions, [ 144 ] which may provide reference for future strategic innovations to improve the diabetic microenvironment by orderly and regular alternations combined with its ability to produce oxygen.…”

Section: Wound Dressing Based On Living Algae As a Treatment Strategy...mentioning

confidence: 99%

Recent Advances in Living Algae Seeding Wound Dressing: Focusing on Diabetic Chronic Wound Healing

Ma,

Fang,

et al. 2023

Adv Funct Materials

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Diabetic chronic wounds (DCWs) are a severe complication of diabetes, and current treatments present several deficiencies, including unsatisfactory efficacy and inability to continuously supply oxygen. This review highlights the recent advances in a novel therapeutic strategy that addresses these challenges: considerable biological powerful inclusions, oxygen or hydrogen and ROS production, DCW glucose consumption, chemotaxis at the wound site, highly editable, great biological safety, low cost, and readily available. Over the past decade, this strategy has shown encouraging results in improving the healing delay induced by hyperglycemia, forming a new concept of “living material” application based on living algae. This review discusses the unique advantages of algae as a treatment strategy, the applications and characteristics of different types of living algae in wound dressings, and the challenges and improvement strategies for this innovative approach.

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Section: Wound Dressing Based On Living Algae As a Treatment Strategy...mentioning

confidence: 99%

Recent Advances in Living Algae Seeding Wound Dressing: Focusing on Diabetic Chronic Wound Healing

Ma,

Fang,

et al. 2023

Adv Funct Materials

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“…In most incidents of “algal infection” (“chlorellosis”) deep traumatic inoculation is almost always involved. Regarding the treatment of green algal infection (“chlorellosis”), the procedure is similar to the treatment of protothecosis with surgical measures and/or drug administration [ 243 , 244 , 246 ]. Algal infections ( Chlorella sp., Chlorochytrium sp., Scenedesmus sp., Cladophora sp.)…”

Section: Pathogenic Algae and The Built Environmentmentioning

confidence: 99%

Toxic or Otherwise Harmful Algae and the Built Environment

Hofbauer

2021

Toxins

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This article gives a comprehensive overview on potentially harmful algae occurring in the built environment. Man-made structures provide diverse habitats where algae can grow, mainly aerophytic in nature. Literature reveals that algae that is potentially harmful to humans do occur in the anthropogenic environment in the air, on surfaces or in water bodies. Algae may negatively affect humans in different ways: they may be toxic, allergenic and pathogenic to humans or attack human structures. Toxin-producing alga are represented in the built environment mainly by blue green algae (Cyanoprokaryota). In special occasions, other toxic algae may also be involved. Green algae (Chlorophyta) found airborne or growing on manmade surfaces may be allergenic whereas Cyanoprokaryota and other forms may not only be toxic but also allergenic. Pathogenicity is found only in a special group of algae, especially in the genus Prototheca. In addition, rare cases with infections due to algae with green chloroplasts are reported. Algal action may be involved in the biodeterioration of buildings and works of art, which is still discussed controversially. Whereas in many cases the disfigurement of surfaces and even the corrosion of materials is encountered, in other cases a protective effect on the materials is reported. A comprehensive list of 79 taxa of potentially harmful, airborne algae supplemented with their counterparts occurring in the built environment, is given. Due to global climate change, it is not unlikely that the built environment will suffer from more and higher amounts of harmful algal species in the future. Therefore, intensified research in composition, ecophysiology and development of algal growth in the built environment is indicated.

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“…Currently, only two algae species causing diseases have been described and confirmed in terrestrial vertebrates, including humans. These species belong to genera Prototheca Krüger, 1894 (Chlorellales: Chlorellaceae) and Chlorella Beyerinck, 1890 (Chlorellales: Chlorellaceae), and cause protothecosis and chlorellosis, respectively (these diseases can also be referred as "algaemia") [1][2][3]. In 2018, the only case of human infection with another microalga, Desmodesmus (Chodat) An, Friedl & Hegewald, 1999 (Sphaeropleales: Scenedesmaceae), was reported in Japan [4].…”

Section: Introductionmentioning

confidence: 99%

Study of the Impact of the Parasitic Microalgae Coccomyxa parasitica on the Health of Bivalve Modiolus kurilensis

Tumas,

Slatvinskaya,

Kumeiko

et al. 2024

Microorganisms

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The invasion of bivalves by parasitic microalgae Coccomyxa is widespread and causes pathologies and dysfunctions of the organs, especially in the most valuable products: the mantle and the muscle. The pathogenesis of the disease remains completely unknown. In this study, based on a macroscopic examination of Modiolus kurilensis and microalgae count in each infected individual, four stages of disease development with characteristic pathognomonic symptoms were described. During the progression of the disease, the concentration of alkaline phosphatase, glucose, calcium, hemolytic and agglutinating activities, number of basophils, eosinophils, phagocytes, and cells with reactive oxygen species increased in the hemolymph, while number of agranulocytes, cells with lysosomes, dead hemocytes, total protein concentration, as well as the weight of mollusks decreased. In the nephridia and digestive gland, necrosis, invasion of Nematopsis sp., hemocyte infiltration, and fibrosis increased. The ratio of changed tubules and occurrence of granulocytomas increased in the digestive gland, while the base membrane, nephrocytes and concretions changed in the nephridia. This study helps establish the variability of these parameters under normal conditions and their alteration during the disease. Moreover, these findings can be used for veterinary monitoring of the state of bivalves in natural and aquaculture populations.

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First case of Chlorella wound infection in a human in Australia

Cited by 9 publications

References 8 publications

Recent Advances in Living Algae Seeding Wound Dressing: Focusing on Diabetic Chronic Wound Healing

Recent Advances in Living Algae Seeding Wound Dressing: Focusing on Diabetic Chronic Wound Healing

Toxic or Otherwise Harmful Algae and the Built Environment

Study of the Impact of the Parasitic Microalgae Coccomyxa parasitica on the Health of Bivalve Modiolus kurilensis

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