First Case of Bloodstream Infection Caused by <i>Ruminococcus gnavus</i> in an 85 Year Old Man in China

Fan, Xiaomei; Chen, Yejin; Liu, Yanqing; Hu, Lina

doi:10.1093/labmed/lmab070

Cited by 8 publications

(4 citation statements)

References 17 publications

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“…These data suggest that R. gnavus infection and potential pathogenicity is associated with damage to the GI tract. In a recent case of bloodstream infection by R. gnavus , the patient was treated with intravenous meropenem and ceftriaxone based on antimicrobial susceptibility tests (Fan et al 2022 ).…”

Section: Association Between R Gnavus and Diseasesmentioning

confidence: 99%

Ruminococcus gnavus: friend or foe for human health

Crost

Coletto

Bell

et al. 2023

FEMS Microbiology Reviews

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Ruminococcus gnavus was first identified in 1974 as a strict anaerobe in the gut of healthy individuals, and for several decades, its study has been limited to specific enzymes or bacteriocins. With the advent of metagenomics, R. gnavus has been associated both positively and negatively with an increasing number of intestinal and extra-intestinal diseases from inflammatory bowel diseases to neurological disorders. This prompted renewed interest in understanding the adaptation mechanisms of R. gnavus to the gut, and the molecular mediators affecting its association with health and disease. From ca. 250 publications citing R. gnavus since 1990, 94% were published in the last 10 years. In this review, we describe the biological characterisation of R. gnavus, its occurrence in the infant and adult gut microbiota and the factors influencing its colonisation of the gastrointestinal tract; we also discuss the current state of our knowledge on its role in host health and disease. We highlight gaps in knowledge and discuss the hypothesis that differential health outcomes associated with R. gnavus in the gut are strain and niche specific.

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Section: Association Between R Gnavus and Diseasesmentioning

confidence: 99%

Ruminococcus gnavus: friend or foe for human health

Crost

Coletto

Bell

et al. 2023

FEMS Microbiology Reviews

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“…Anaerococcus have the potential to metabolize peptones and amino acids and to produce short-chain fatty acids (SCFAs), such as butyric acid, but can be associated with skin and soft tissue infections and chronic wounds [41]. Ruminococcus and [Eubacterium] are usually the part of the resident microflora and also produce SCFAs; in some case, they may be players in the development of inflammation and bloodstream infection [42,43]. The balance on 1st day in infectious group is Prevotella/Actinomyces.…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiota as Early Predictor of Infectious Complications before Cardiac Surgery: A Prospective Pilot Study

Chernevskaya

Zuev

Odintsova³

et al. 2021

JPM

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Cardiac surgery remains a field of medicine with a high percentage of postoperative complications, including infectious ones. Modern data indicate a close relationship of infectious disorders with pathological changes in the composition of the gut microbiome; however, the extent of such changes in cardiac surgery patients is not fully clarified. In this prospective, observational, single center, pilot study, 72 patients were included, 12 among them with the infectious complications. We analyzed the features of the fecal microbiota before and in the early postoperative period, as one of the markers for predicting the occurrence of bacterial infection. We also discovered the significant change in microbial composition in the group of patients with infectious complications compared to the non-infectious group before and after cardiac surgery, despite the intra-individual variation in composition of gut microbiome. Our study demonstrated that the group of patients that had a bacterial infection in the early postoperative period already had an altered microbial composition even before the surgery. Further studies will evaluate the clinical significance of the identified proportions of individual taxa of the intestinal microbiota and consider the microbiota as a novel target for reducing the risk of infectious complications.

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“…[54] Ruminococcus is a resident microbe that also produces SCFAs; nevertheless, in specific circumstances, they may cause inflammation and bloodstream infection. [55]…”

Section: Complications and Risk Factors For Cardiac Surgerymentioning

confidence: 99%

Dysbiosis of Gut Microbiota in Patients Undergoing Cardiac Surgery

Paneri

Sevta

2022

GJMPBU

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The diversity of bacteria, viruses, eukaryotic organisms, and archaea that live in the gastrointestinal tract and have coevolved with the host over thousands of years to establish a complex and advantageous relationship is referred to as the “gut microbiota” or “gut microbiome.” The numerous and diverse gut microbiota play an important role mostly in the betterment of human health by facilitating the breakdown of food to release nutrients that would otherwise be inaccessible to the host, encouraging host cells proliferation and differentiation, defending the host against pathogen colonization, and activating or modulating the immune system. The gut microbial community plays an important role in protecting the host against pathogenic microbes, modulating immunity, and regulating metabolic processes and is even regarded as an endocrine organ. The term “dysbiosis” refers to the imbalance of the gut bacterial microbiota, which has been linked to several disorders such as cardiovascular diseases, obesity, irritable bowel syndrome, colorectal cancer, and sepsis. During cardiac surgery, intestinal ischemia-reperfusion causes an inflammatory response throughout the body. Since the intestines are an organ that is vulnerable to ischemia, germs and endotoxins can move between organs. As a consequence, the gut leads to sepsis after surgery. Next-generation sequencing technologies have enabled analysis of a large number of microorganisms. Metagenomics can be used to study intestinal microbiome diversity and dysbiosis, as well as its relationship to health and disease. Sequence-based and multifunctional metagenomics will also provide insights that will lead to greater knowledge than it is ever been of the structural and functional microbiomes.

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First Case of Bloodstream Infection Caused by Ruminococcus gnavus in an 85 Year Old Man in China

Cited by 8 publications

References 17 publications

Ruminococcus gnavus: friend or foe for human health

Ruminococcus gnavus: friend or foe for human health

Gut Microbiota as Early Predictor of Infectious Complications before Cardiac Surgery: A Prospective Pilot Study

Dysbiosis of Gut Microbiota in Patients Undergoing Cardiac Surgery

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