First case of a bloodstream infection caused by the genus Brachybacterium

Tamai, Kazuya; Akashi, Yusaku; Yoshimoto, Yuta; Yaguchi, Yuji; Takeuchi, Yosuke; Shiigai, Masanari; Igarashi, Jun; Hirose, Yumi; Suzuki, Hiromichi; Ohkusu, Kiyofumi

doi:10.1016/j.jiac.2018.06.005

Cited by 25 publications

(21 citation statements)

References 25 publications

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“…Tamai et al reported that the results of culture and PCR examinations of blood samples were positive for B. paraconglomeratum, but cultures of samples of the intervertebral disc were negative for B. paraconglomeratum in cultures and microscopic examinations [1]. Our sample from the anterior chamber tap was very small and was negative in culture and PCR examination.…”

Section: Discussionmentioning

confidence: 59%

“…belong to the Actinomycetales and are nonsporing gram-positive rods [3]. They are considered to be nonharmful environmental bacteria [1]. The Brachybacterium spp.…”

Section: Discussionmentioning

confidence: 99%

“…was first proposed by Tamai et al in 2018, but there are only a few reports of Brachybacterium spp. isolated from human samples [1,[6][7][8]. It is not known why human infections by Brachybacterium spp.…”

Section: Discussionmentioning

confidence: 99%

“…Takeuchi et al also performed a taxonomic study including B. paraconglomeratum with BHI agar [5]. However, the laboratories of many hospitals and outside institutions generally use 5% sheep blood agar, chocolate agar, and Sabouraud dextrose agar as conventional agars [1].…”

Section: Discussionmentioning

confidence: 99%

“…However, it is occasionally difficult to detect the causative pathogens from the collected samples by conventional examinations, microscopy, and culturing. The advances in the molecular techniques for detecting and identifying organisms by the polymerase chain reaction (PCR) method have enabled more accurate and faster identification of various pathogens which were unable to be detected earlier [1,2].…”

Section: Introductionmentioning

confidence: 99%

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Brachybacterium paraconglomeratum Endophthalmitis Postcataract Operation

Murata

Ozawa

Kawakami

et al. 2020

Case Reports in Ophthalmological Medicine

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Purpose. To present our findings in a case of delayed-onset postoperative endophthalmitis caused by Brachybacterium paraconglomeratum, a rare organism. Observations. A 57-year-old man presented with epiphora and photophobia 17 weeks after a routine cataract extraction with phacoemulsification and intraocular lens implantation. Because endophthalmitis was suspected to be caused by a low-grade pathogen or fungus, an anterior chamber tap was performed. However, both multiplex PCR and culturing were negative. The patient was treated with topical cefmenoxime, oral minocycline, and subconjunctival injection of vancomycin and ceftazidime, but the intraocular inflammation increased. Then, the anterior chamber was tapped again, and the second PCR amplification and direct sequencing which targeted Actinomycetes detected Brachybacterium paraconglomeratum. This pathogen is uncommon for human infections. He was treated with oral amoxicillin, and his intraocular condition slowly improved. Conclusion. This is the first reported case of an ocular disorder caused by B. paraconglomeratum. We recommend that B. paraconglomeratum be considered in cases of delayed-onset postcataract endophthalmitis.

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Section: Discussionmentioning

confidence: 59%

“…belong to the Actinomycetales and are nonsporing gram-positive rods [3]. They are considered to be nonharmful environmental bacteria [1]. The Brachybacterium spp.…”

Section: Discussionmentioning

confidence: 99%