First and Second Trimester Biochemical Markers in Maternal Epilepsy: A Case-Control Study

Öksüzoğlu, Ayşegül; Üstün, Yaprak Engin; Aktulay, Ayla; Yörük, Özlem; Seckin, Berna; Danışman, Nuri

doi:10.1080/15513815.2018.1502381

Cited by 1 publication

(4 citation statements)

References 17 publications

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“…Two studies in the literature studied the influence of antiepileptic drugs on aneuploidy screening test results 12,16 . Unal et al interpreted the first‐trimester screening test serum markers and found significantly higher levels of free b‐hCG in the maternal serum of pregnant women with epilepsy who use antiepileptic drugs, different from the control group 16 .…”

Section: Discussionmentioning

confidence: 99%

“…Two studies in the literature studied the influence of antiepileptic drugs on aneuploidy screening test results. 12,16 Unal et al interpreted the first-trimester screening test serum markers and found significantly higher levels of free b-hCG in the maternal serum of pregnant women with epilepsy who use antiepileptic drugs, different from the control group. 16 Oksuzoglu et al showed, hıgher levels of uE3 in pregnant women with epilepsy in the second trimester, but levels of AFP in the second trimester were similar between the epileptic and control groups.…”

Section: Discussionmentioning

confidence: 99%

“…16 Oksuzoglu et al showed, hıgher levels of uE3 in pregnant women with epilepsy in the second trimester, but levels of AFP in the second trimester were similar between the epileptic and control groups. 12 What can be the causes of increased AFP and uE3 in second-trimester screening tests?…”

Section: Discussionmentioning

confidence: 99%

“…A recent study 12 proposed that the hCG levels in the control group were found to be 1.13 MoM, in the case group were found to be a 1.50 MoM which makes a total of 106 patients (53 patients in each group) to achieve 95% power at two‐sided 5% significance level. For the whole statistical analysis, the Statistical Package for Social Sciences (SPSS) for Windows (SPSS version 23; SPSS Inc., Chicago, IL) statistical software package was used.…”

Section: Methodsmentioning

confidence: 97%

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Effect of antiepileptic drugs on serum biochemical marker levels of first and second trimester screening tests

Besimoğlu

Öcal

Sınacı

et al. 2022

J of Obstet and Gynaecol

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Objectives: Our aim in this study was to evaluate the effect of antiepileptic drugs on biochemical components of screening tests. Materials and Methods: This longitudinal case-control study was performed at Ankara City Hospital, Ankara, Turkey, from June 2020 to January 2021. The case group included epileptic singleton pregnant women which were using antiepileptic drugs, between 18 and 44 years of age. The control group included healthy pregnant women between 18 and 44 years old who did not use any drugs. Maternal medical, obstetric, and gynecological history were recorded. The antiepileptic agents that are used in our study were; lamotrigine, levetiracetam, carbamazepine, oxcarbazepine, valproic acid, and clonazepam. For the aneuploidy screening program conducted in our laboratory, the biochemical markers that are analyzed include; free b-hCG and PAPP-A in the first trimester, as well as AFP, HCG, and unconjugated estriol (uE3) in the second trimester. MoM values of these markers were compared between the case and control groups. Results: Fifty-three pregnant women with epilepsy using antiepileptic drugs were compared with 106 healthy pregnant women. The levels of serum-free b-hCG, and PAPP-A were similar between the case and control groups (p = 0.653, p = 0.351). For the second-trimester screening biochemical markers, the maternal serum uE3 and AFP levels expressed as MoM were significantly higher in the epileptic group than in the control patients (p = 0.015 and p = 0.001). Conclusion: Serum marker levels of second-trimester screening tests may be affected by antiepileptic drugs, which may lead to misinterpretation of the risk level. Antiepileptic drug usage should be considered when evaluating screening test results.

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Section: Discussionmentioning

confidence: 99%