First and Second Level Haemoglobinopathies Diagnosis: Best Practices of the Italian Society of Thalassemia and Haemoglobinopathies (SITE)

Abstract

The purpose of this best practice paper is to review the current recommendations for the identification and prenatal diagnosis of hemoglobinopathies. Methods: The management committee of SITE selected and gathered a multidisciplinary team in order to formulate recommendations based on the available scientific evidence integrated with the opinions of experts, with the purpose of supporting clinicians. Results: We provide recommendations for first level tests (complete blood count, hemoglobin separation and iron balance), second level tests (molecular diagnosis) and prenatal diagnosis. Five Italian experts in hemoglobinopathies were consulted regarding the orientation of prenatal diagnosis, and for each indication, the degree of agreement among the experts has been specified. Conclusions: Best practice recommendations are the final outcome of this translational research and allow transfer to daily clinical practice.

Hematological Studies of an Ayurvedic Medicine “Vata Gajendra Singha” Used in Rheumatoid Arthritis After Chronic Administration to Male Sprague-Dawley Rats

“…31 MPV is a useful prognostic marker in myriad medical conditions, including ischemic heart disease, infective endocarditis, and cerebral infarction. [32][33][34] MPV may act as a risk factor for recurring myocardial infarction independent of established risk factors, which is simple and economical laboratory aid along with traditional cardiac biomarkers for risk stratification of acute coronary syndrome patients admitted to the emergency. 35 In both doses, MPV increased significantly (<p=.05) after chronic administration of the VGS (Table 3).…”

Difference in Hemoglobin Value Between Prick Test and Venous Puncture: Implication of Iron Supplementation in Pregnant Women in Primary Health Care, Bengkulu, Indonesia

“…To appropriately screen individual with anemia after complete iron therapy, a complete blood count (CBC), iron balance and complete Hb analysis (HbA2-HbF-Hb variant) are required. (Mandrile et al, 2022). As for normal HbA2 or <3.5%, the definite diagnosis needed to be further explored whether the etiology of iron deficiency anemia or α-thalassemia carrier by iron status analysis or DNA examination.…”