Firm Red-Brown Plaques in a Patient With Systemic Scleroderma

Zacher, Natasha C; Rieger, Kerri E.; Bailey, Elizabeth E.

doi:10.1001/jamadermatol.2022.3241

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2023

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“…The histopathology of keloidal scleroderma shows keloidal or sclerodermatous features. Specifically, the keloidal pattern shows brightly eosinophilic or glassy collagen bundles organized haphazardly in the dermis, while scleroderma shows thick sclerotic collagen bundles arranged parallel to the epidermis with perivascular lymphocytic and plasmacytoid infiltration ( 3 ). The differential diagnosis includes hypertrophic scar, keloid, and scleromyxedema.…”

Section: Discussionmentioning

confidence: 99%

Nodular and diffuse spindle cell infiltration in keloidal scleroderma: a case report

Li,

Zeng,

Chen

et al. 2023

Front. Med.

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Keloidal scleroderma is a variant of scleroderma that presents as firm keloidal nodules or plaques. Due to the similarity in morphology and pathology, it is often distinguished from a hypertrophic scar or keloid. We report a case of keloidal scleroderma with rare nodular and diffuse spindle cell infiltration in histopathology. Recognition of this unusual histopathological feature may help clinicians improve their knowledge and avoid misdiagnosis.

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Section: Discussionmentioning

confidence: 99%