Firefighting and melanoma, epidemiological and toxicological associations: a case report

Brinchmann, Bendik Christian; Bugge, Merete; Nordby, Karl-Christian; Alfonso, José Hernán

doi:10.1093/occmed/kqab183

Cited by 3 publications

(1 citation statement)

References 14 publications

(11 reference statements)

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“…Many pollutants generated at disaster sites, including fires, are associated with chronic health outcomes, such as cancer [23,[38][39][40][41]. The emergency decontamination of PPE is very important for firefighters because the dust generated at disaster sites, such as fires, can be absorbed through the respiratory system and skin [23].…”

Section: Efforts Interventions and Implications For Practicing Occupa...mentioning

confidence: 99%

Associations between Recognition and Behaviors Regarding the Use, Washing and Management of Firefighting Protection Suits and Public Health Awareness of Occupational Exposure Risks among Firefighters

Kim,

Ham

2024

Fire

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The firefighting protective suits (FPSs) of firefighters at fire scenes affect their health and safety. However, the association between firefighters’ health awareness of occupational exposure risks and the FPS use, washing and management remains unclear. Therefore, this study aimed to evaluate the association between firefighters’ health awareness of occupational exposure risks and their recognition, behaviors regarding the use, washing and management of FPSs. This study design is a cross-sectional study and used a web-based survey of the Seoul Metropolitan Government’s electronic survey system. The survey was conducted on metropolitan firefighters performing shift work in charge of fire and rescue work for 21 days from 1 to 22 April 2019, with 1097 (40.3%) respondents. Characteristics of FPS use, washing and management and the association between thoughts and behaviors thereof and health awareness of occupational exposure risks were evaluated. Data of 1097 firefighters were analyzed using the SAS 9.4 statistical package, chi-square test and logistic regression analysis. Firefighters’ fire scene awareness rate of possible carcinogens was 94.4%. There was an association between public health thinking of occupational exposure risks and the correct use of an FPS for one’s own safety (AOR 1.97. 95% CI 1.02–3.80). However, no association was shown between correct FPS use (AOR 1.49, 95% CI 0.48–4.59), washing (AOR 2.50, 95% CI 0.93–6.68) and management (AOR 1.38, 95% CI 0.75–2.50) behaviors. This study analyzed the relationship between the use, washing and management of personal protective equipment called firefighting clothing and firefighters perceived occupational exposure risks. This study found an association between the health awareness of occupational exposure risks and recognition of the correct use of FPSs at fire scenes but not between using, washing and managing behaviors of FPSs. This study is the first to analyze the relationship between firefighting clothing and occupational health awareness level. The results confirm that future interventions are required to help firefighters practice desirable behaviors toward FPSs and provided evidenced data for preventing occupational diseases among firefighters. Therefore, this study can be used to develop a firefighter occupational health curriculum and establish health and safety plans from mid- to long-term perspectives for firefighters’ safety against occupational exposure risks.

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Section: Efforts Interventions and Implications For Practicing Occupa...mentioning

confidence: 99%

Associations between Recognition and Behaviors Regarding the Use, Washing and Management of Firefighting Protection Suits and Public Health Awareness of Occupational Exposure Risks among Firefighters

Kim,

Ham

2024

Fire

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In this issue of Occupational Medicine

Moen

2022

Occupational Medicine

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Genetic factors of toxic effects development in pollution liquidators of the former factory with mercury electrolysis technology

Chernyak

Merinova

2022

Med. tr. prom. èkol.

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Introduction. According to genetic factors, it is possible to determine the degree of manifestation of the toxic effects of mercury. The latter justifies the assessment of the genetic status of the exposed contingent in order to identify hypersensitive individuals in whom adverse health effects can be realized when exposed to relatively low levels of the toxicant. The study aims to research the distribution of genotypes of some polymorphic variants of genes of the xenobiotic biotransformation system, heat shock proteins and tumor necrosis factor in the contingent involved in liquidation measures, as well as to identify individuals with a high prognostic risk of toxic effects due to exposure to mercury. Materials and methods. We conducted genotyping of 231 people (men only): 193 employees of the Ministry of Emergency Situations (MES) of Russia in the Irkutsk Region and 38 employees of the Federal Environmental Operator (FEO) involved in the elimination of mercury pollution at the industrial site of the mercury electrolysis plant and adjacent facilities on the territory of a former chemical plant in Eastern Siberia. The researchers used real-time PCR and PCR-RFLP methods to study polymorphic variants of the genes CYP1A1 (rs1048943), GSTP1 (rs1695 and rs1138272), TNF-α (rs1800629) and HSPA1B (rs1061581). Results. For the polymorphism of the GSTP1 gene (rs1695), we have identified an increase in the frequency of AG genotypes (p=0.043) and a decrease in the frequency of GG genotypes (p=0.048) in employees of the MES compared to those from the FEO group. The researchers didn’t detect carriers of the TT genotype for the polymorphic locus GSTP1 (rs1138272) in both examined groups. There was the carriage of the rare GG-CYP1A1 homozygote only in one MES employee. We found that 33 MES employees and 3 examined from the FEO group who are carriers of the GG-HSPA1B (+1267A/G) genotype have a high predictive risk of developing toxic effects due to mercury exposure. The experts discussed the data obtained with the results of genotyping of former mercury electrolysis shop workers who were chronically exposed to metallic mercury vapor. The experts have reviewed the data obtained from the results of genotyping of former employees of the mercury electrolysis shop who were chronically exposed to metallic mercury vapor Limitations. The limitations, first of all, should include the number of examined individuals in the FEO group, as well as the lack of data on deletion polymorphisms of the GSTT1 and GSTM1 genes, potentially having a significant role in the toxicokinetics of mercury. Conclusion. The study has revealed 36 carriers of the GG genotype of the polymorphic locus +1267A/G of the HSPA1B gene associated with a high prognostic risk of toxic effects associated with exposure to mercury among the employees of the Ministry of Emergency Situations (MES) and the FEO involved in liquidation work. Taking into account the forthcoming volume and duration of work related to the demercurization of the territory of the former factory with mercury electrolysis technology and the surrounding area it is advisable to take into account the results obtained when monitoring the health status of the liquidators. Ethics. We have received voluntary informed consent, approved by the Committee on Biomedical Ethics (Protocol No. 6 of 10.03.2020), from each employee being examined.

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Firefighting and melanoma, epidemiological and toxicological associations: a case report

Cited by 3 publications

References 14 publications

Associations between Recognition and Behaviors Regarding the Use, Washing and Management of Firefighting Protection Suits and Public Health Awareness of Occupational Exposure Risks among Firefighters

Associations between Recognition and Behaviors Regarding the Use, Washing and Management of Firefighting Protection Suits and Public Health Awareness of Occupational Exposure Risks among Firefighters

In this issue of Occupational Medicine

Genetic factors of toxic effects development in pollution liquidators of the former factory with mercury electrolysis technology

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