Background: Gun related mortality rate in the USA surpassed other developed countries. This study hypothesizes that injury patterns, weapon type, and mortality differ between suicide groups as opposed to homicide. Methods: The National Trauma Database (NDTB) was queried from January 2017 to December 2019. All firearm related injuries were included, and weapon type was abstracted. Differences between homicide and suicide groups by sex, age, race, and injury severity were compared using a Mann-Whitney test for numerical data and Fisher’s exact test for categorical data. The association between weapon type and mortality relative to suicide as opposed to homicide was assessed in Fisher’s exact tests. Significance was defined as p < 0.05. Results: There was 100,031 homicide and 11,714 suicide subjects met inclusion criteria. Homicides were mostly assault victims (97.6%), male (88%), black (62%), less severe injury (mean ISS 12.07) and median age 20 years old (IQR: 14, 30), (p < 0.01). Suicides were mostly male (83%), white (79%), more severe injury (mean ISS 20.73), and median age of 36 years old (IQR: 19, 54, p < 0.01). Suicide group had higher odds of head/neck (OR=13.6) or face (OR=5.7) injuries, with lower odds of injury to chest (OR=0.55), abdominal or pelvic contents (OR=0.25), extremities or pelvic girdle (OR=0.15), or external areas (OR=0.32). Mortality rate was higher for suicide group (44.8%; 95% confidence interval (CI): 43.9%, 45.7%) compared to the homicide group (11.5%; 95% CI: 11.3%, 11.7%). Conclusions: Suicide had higher mortality, more severe injuries, and more head/neck/facial injuries than homicide. Majority of suicides were with handguns. Level of Evidence: Level IV