Fire Needling Acupuncture Suppresses Cartilage Damage by Mediating Macrophage Polarization in Mice with Knee Osteoarthritis

Wei, Jiangyan; Liu, Lu; Li, Zhijuan; Lyu, Tianli; Zhao, Luopeng; Xu, Xiaobai; Song, Yine; Dai, Yuchao; Li, Bin

doi:10.2147/jpr.s360555

Cited by 9 publications

(9 citation statements)

References 62 publications

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“…Our research team has found that fire needling therapy decreases pain-related behaviors in KOA mice and improves synovial membrane injury and pathological cartilage damage. 43 However, fire needling therapy is rarely compared with the first-line drugs recommended by guidelines. 44 At the same time, the relationship between acupuncture dose and effect has been paid more attention by researchers, and it has been found that acupuncture frequency is one of the aspects of acupuncture dose, whereas the study about dose–effect property of fire needling therapy is limited.…”

Section: Discussionmentioning

confidence: 99%

Fire Needling Therapy of Different Frequencies versus External Diclofenac Diethylamine Emulgel for Knee Osteoarthritis: Study Protocol for a Pilot Randomized Controlled Trial

Wang¹,

Xu²,

Zhao³

et al. 2023

JPR

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Knee osteoarthritis (KOA) is regarded as one of the leading musculoskeletal diseases. Although the efficacy is under exploration, fire needling therapy is considered an effective alternative for KOA. This trial aims to investigate the effectiveness of different frequencies of fire needling therapy in attenuating pain and promoting function in KOA patients. Methods: This is a study protocol for a pilot, three-arm, single-center, randomized controlled trial. A total of 90 participants with KOA will be recruited and randomly assigned to the high-frequency fire needling group (3 sessions per week, for 6 weeks), the lowfrequency fire needling group (1 session per week, for 6 weeks) or the positive control group (Diclofenac Diethylamine Emulgel, 3 times per day, for 6 weeks) in a 1:1:1 ratio. Participants will accomplish the trial at Week 14 after a follow-up evaluation. The response rate will be set as the primary outcome that the proportion of participants obtaining a minimal clinically important difference, which is identified as ≥2 units on the numerical rating scale (NRS) and ≥6 units on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) function score at Week 6 compared with Week 0. Secondary outcomes are NRS, WOMAC, Brief Pain Inventory, Short-Form Health Survey-12, Timed Up and Go Test, and pain threshold. Discussion: This is the first standardized protocol comparing fire needling therapy and positive control drugs. This trial may provide reliable evidence for the effectiveness of fire needling therapy and dose-effect property of it in KOA. Trial registration: The trial has been registered on Chinese Clinical Trial Registry (Registered number: ChiCTR2100043041), registered on 4 February 2021.

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Section: Discussionmentioning

confidence: 99%

Fire Needling Therapy of Different Frequencies versus External Diclofenac Diethylamine Emulgel for Knee Osteoarthritis: Study Protocol for a Pilot Randomized Controlled Trial

Wang¹,

Xu²,

Zhao³

et al. 2023

JPR

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“…Fire needle therapy has demonstrated efficacy in moderating and inhibiting cytokines such as IL-1, IL-6, IL-1β, and TNF-α, contributing to the reestablishment of immune balance. [30] (2) Mediation of inflammation:…”

Section: Fire Needle Mechanismmentioning

confidence: 99%

The effectiveness of fire needle therapy in the treatment of recurrent aphthous stomatitis: A systematic review and meta-analysis

Wu,

Cheng,

et al. 2024

Medicine

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Background: Recurrent aphthous stomatitis (RAS) is common in clinical practice and imposes both physical and psychological distress on patients. Objective: This study aimed to evaluate the clinical effectiveness of fire needle therapy for the treatment of RAS, providing a basis for clinical decision-making. Methods: Eight databases, in both Chinese and English, were searched from their inception until December 2022. All randomized controlled trials (RCTs) that utilized fire needle therapy, either alone or combined with other treatments for RAS, were considered. Data evaluation and extraction were conducted independently by 2 authors. Results: The revised Cochrane Risk of Bias Version 2 tool was employed to assess the risk of bias in the included RCTs. A meta-analysis was conducted using Review Manager 5.4 and Stata 15.0. Nine RCTs involving 1469 patients were selected for inclusion. The meta-analysis revealed that, compared to a non-fire-needle control group (primarily utilizing vitamin and transfer factor treatments), fire needle therapy for RAS significantly improved the total effective rate (relative risk = 1.25, 95% confidence interval [CI] [1.14, 1.36], P < .00001), reduced the visual analogue scale score (mean difference = −1.68, 95% CI [−1.82, −1.53], P < .0001), diminished the Traditional Chinese Medicine symptom score (standardized mean difference = −1.20, 95% CI [−1.76, −0.65], P < .0001), and shortened the healing time (mean difference = −1.66, 95% CI [−2.73, −0.59], P = .002). Notably, there was no significant difference in the recurrence rate between the groups (relative risk = −0.18, 95% CI [−0.36, 0.01], P = .06). Further subgroup analysis on total efficacy rate was performed based on variables such as experimental group intervention, control group intervention, and duration of therapy to explore potential sources of heterogeneity. Conclusion: Fire needle therapy appears to be a clinically effective treatment for RAS, offering benefits such as pain alleviation, symptom improvement based on the Traditional Chinese Medicine parameters, and faster recovery. Nonetheless, the overall quality of the RCTs available raises concerns. Future research, involving high-quality RCTs, is essential to confirm the clinical efficacy and safety of this treatment. Registration number: PROSPERO (CRD42023387973).

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“…The fire needling applied to KOA mice confirmed this process. [32][33][34] Wang et al 35 found that after trinitrobenzene sulfonic acid (TNBS) stimulation, tyrosine hydroxylase immunoreactive (TH-IR) neurons in the L6 dorsal root ganglion of colitis rats increased and overgrew to sensory neurons, resulting in colitis and secondary hindfoot hypersensitivity. Applications of EA at ST36 and ST37 can reduce colitis and allergic reaction, which may be mediated by inhibiting TH-IR germination in L6 Dorsal root ganglion (DRG).…”

Section: Immune Cells and Neuronsmentioning

confidence: 99%

Mechanisms of acupuncture–electroacupuncture on inflammatory pain

Zhang,

Zhou,

Huo

et al. 2023

Mol Pain

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Acupuncture, as a traditional treatment, has been extensively used in China for thousands of years. According to the World Health Organization (WHO), acupuncture is recommended for the treatment of 77 diseases. And sixteen of these diseases are related to inflammatory pain. As a combination of traditional acupuncture and modern electrotherapy, electroacupuncture (EA) has satisfactory analgesic effects on various acute and chronic pain. Because of its good analgesic effects and no side effects, acupuncture has been widely accepted all over the world. Despite the increase in the number of studies, the mechanisms via which acupuncture exerts its analgesic effects have not been conclusively established. A literature review of related research is of great significance to elaborate on its mechanisms and to inform on further research directions. We elucidated on its mechanisms of action on inflammatory pain from two levels: peripheral and central. It includes the mechanisms of acupuncture in the periphery (immune cells and neurons, purinergic pathway, nociceptive ion channel, cannabinoid receptor and endogenous opioid peptide system) and central nervous system (TPRV1, glutamate and its receptors, glial cells, GABAergic interneurons and signaling molecules ). In this review, we collected relevant recent studies to systematically explain the mechanisms of acupuncture in treating inflammatory pain, with a view to providing direction for future applications of acupuncture in inflammatory pain and promoting clinical development.

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Fire Needling Acupuncture Suppresses Cartilage Damage by Mediating Macrophage Polarization in Mice with Knee Osteoarthritis

Cited by 9 publications

References 62 publications

Fire Needling Therapy of Different Frequencies versus External Diclofenac Diethylamine Emulgel for Knee Osteoarthritis: Study Protocol for a Pilot Randomized Controlled Trial

Fire Needling Therapy of Different Frequencies versus External Diclofenac Diethylamine Emulgel for Knee Osteoarthritis: Study Protocol for a Pilot Randomized Controlled Trial

The effectiveness of fire needle therapy in the treatment of recurrent aphthous stomatitis: A systematic review and meta-analysis

Mechanisms of acupuncture–electroacupuncture on inflammatory pain

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