Fipronil toxicity in northern bobwhite quail Colinus virginianus: Reduced feeding behaviour and sulfone metabolite formation

Kitulagodage, Malsha; Isanhart, John P.; Buttemer, William A.; Hooper, Michael J.; Astheimer, Lee B.

doi:10.1016/j.chemosphere.2010.12.057

Cited by 48 publications

(31 citation statements)

References 19 publications

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“…This range-wide decline in bobwhite abundance across most of the U.S. is still ongoing today [22]–[23]. The precise reasons for recent population declines in the U.S. appear to be a complex issue, and have been attributed to factors such as variation in annual rainfall [2], [12]–[13], thermal tolerances of developing embryos within a period of global warming [24]–[25], shifts in land use and scale coupled with the decline of suitable habitat [2]–[3], [14], [20]–[21], red imported fire ants ( Solenopsis invicta ) [26]–[27], sensitivity to ecotoxins [28]–[29], and harvest intensity by humans [30]–[32], particularly during drought conditions [3], [13]. Population declines have prompted intense recent efforts to translocate bobwhites to fragmented parts of their historic range where modern abundance is low.…”

Section: Introductionmentioning

confidence: 99%

A Draft De Novo Genome Assembly for the Northern Bobwhite (Colinus virginianus) Reveals Evidence for a Rapid Decline in Effective Population Size Beginning in the Late Pleistocene

Halley

Dowd²,

Decker

et al. 2014

PLoS ONE

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Wild populations of northern bobwhites (Colinus virginianus; hereafter bobwhite) have declined across nearly all of their U.S. range, and despite their importance as an experimental wildlife model for ecotoxicology studies, no bobwhite draft genome assembly currently exists. Herein, we present a bobwhite draft de novo genome assembly with annotation, comparative analyses including genome-wide analyses of divergence with the chicken (Gallus gallus) and zebra finch (Taeniopygia guttata) genomes, and coalescent modeling to reconstruct the demographic history of the bobwhite for comparison to other birds currently in decline (i.e., scarlet macaw; Ara macao). More than 90% of the assembled bobwhite genome was captured within <40,000 final scaffolds (N50 = 45.4 Kb) despite evidence for approximately 3.22 heterozygous polymorphisms per Kb, and three annotation analyses produced evidence for >14,000 unique genes and proteins. Bobwhite analyses of divergence with the chicken and zebra finch genomes revealed many extremely conserved gene sequences, and evidence for lineage-specific divergence of noncoding regions. Coalescent models for reconstructing the demographic history of the bobwhite and the scarlet macaw provided evidence for population bottlenecks which were temporally coincident with human colonization of the New World, the late Pleistocene collapse of the megafauna, and the last glacial maximum. Demographic trends predicted for the bobwhite and the scarlet macaw also were concordant with how opposing natural selection strategies (i.e., skewness in the r-/K-selection continuum) would be expected to shape genome diversity and the effective population sizes in these species, which is directly relevant to future conservation efforts.

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Section: Introductionmentioning

confidence: 99%

A Draft De Novo Genome Assembly for the Northern Bobwhite (Colinus virginianus) Reveals Evidence for a Rapid Decline in Effective Population Size Beginning in the Late Pleistocene

Halley

Dowd²,

Decker

et al. 2014

PLoS ONE

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“…Fipronil has a higher binding affinity for insect than mammalian GABA receptors , suggesting a level of safety for vertebrates. Nonetheless, FIP has been shown to be moderately to highly toxic to some nontarget birds and fish . We hypothesized that pesticides with GABA‐modulating activities, such as FIP, may have the potential to impair fish reproduction at sublethal concentrations.…”

Section: Introductionmentioning

confidence: 99%

Effects of the insecticide fipronil on reproductive endocrinology in the fathead minnow

Bencic

Villeneuve

Blake

et al. 2013

Enviro Toxic and Chemistry

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Gamma-aminobutyric acid (GABA) and GABA receptors play an important role in neuroendocrine regulation in fish. Disruption of the GABAergic system by environmental contaminants could interfere with normal regulation of the hypothalamic-pituitary-gonadal axis, leading to impaired fish reproduction. The present study used a 21-d fathead minnow (Pimephales promelas) reproduction assay to investigate the reproductive toxicity of fipronil (FIP), a broad-spectrum phenylpyrazole insecticide that acts as a noncompetitive blocker of GABA receptor-gated chloride channels. Continuous exposure up to 5 µg FIP/L had no significant effect on most of the endpoints measured, including fecundity, secondary sexual characteristics, plasma steroid and vitellogenin concentrations, ex vivo steroid production, and targeted gene expression in gonads or brain. The gonad mass, gonadosomatic index, and histological stage of the gonad were all significantly different in females exposed to 0.5 µg FIP/L compared with those exposed to 5.0 µg FIP/L; however, there were no other significant effects on these measurements in the controls or any of the other treatments in either males and females. Overall, the results do not support a hypothesized adverse outcome pathway linking FIP antagonism of the GABA receptor(s) to reproductive impairment in fish.

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“…Northern bobwhite is one of the most widely managed species, but the species has experienced drastic population declines mainly due to large-scale habitat loss and fragmentation from changes in land use (Brennan 1991, Hern andez et al 2012, Crosby et al 2015. Although agricultural chemicals are likely not a major cause of population declines (Hern andez et al 2012), survival of birds in a localized area can be negatively influenced by ingestion of seeds and insects contaminated with insecticides (Brewer et al 1996, Kitulagodage et al 2011 or naturally occurring toxins, such as mycotoxins and plant secondary metabolites (Price et al 1993).…”

mentioning

confidence: 99%

Response of northern bobwhites fed single doses of gossypol

et al. 2018

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Cottonseed products have been used as a feed supplement for ruminant livestock and white‐tailed deer (Odocoileus virginianus). Gossypol, a secondary plant metabolite found in cotton (Gossypium spp.), is known to be toxic to a variety of animals, specifically monogastric mammals and birds. However, there are no published data regarding the effects of gossypol in northern bobwhites (Colinus virginianus). Our goal was to determine whether ingestion of gossypol presents a threat to northern bobwhite survival and reproduction. We performed this study at Tarleton State University Northern Bobwhite Research Center (Stephenville, TX, USA) during March and April 2016, using the Environmental Protection Agency's 850.2100 Guideline: Avian Acute Oral Toxicity Test. We administered one‐time doses of refined gossypol to northern bobwhites at 20 mg/kg, 200 mg/kg, 262 mg/kg, 342 mg/kg, 447 mg/kg, 585 mg/kg, 765 mg/kg, and 1,000 mg/kg body weight (BW) and observed them daily throughout a 14‐day period. We measured feed consumption daily and body mass weekly. Birds receiving larger doses (447–1,000 mg/kg BW) consumed less total feed postdosing (55.46 ± 56.46 g, n = 39) and had greater, negative postdosing percent change in mass (−23.02 ± 13.04%, n = 85) compared with control birds and those receiving lower doses (20–342 mg/kg BW). We also examined laying performance and egg quality of birds dosed with 20 mg/kg and 200 mg/kg BW (n = 30 pairs) and the growth rate and percent mortality of second‐generation young produced from these pairs. There was no difference in laying performance, egg quality, the percentage of chicks that hatched, and the growth rate and percent mortality of chicks between the dosing rates. Our results suggest that gossypol can have adverse effects on feed consumption and body mass in northern bobwhites at sufficient doses; however, a one‐time acute dose of gossypol up to 200 mg/kg BW does not pose any negative reproductive effects. © 2018 The Wildlife Society.

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Fipronil toxicity in northern bobwhite quail Colinus virginianus: Reduced feeding behaviour and sulfone metabolite formation

Cited by 48 publications

References 19 publications

A Draft De Novo Genome Assembly for the Northern Bobwhite (Colinus virginianus) Reveals Evidence for a Rapid Decline in Effective Population Size Beginning in the Late Pleistocene

A Draft De Novo Genome Assembly for the Northern Bobwhite (Colinus virginianus) Reveals Evidence for a Rapid Decline in Effective Population Size Beginning in the Late Pleistocene

Effects of the insecticide fipronil on reproductive endocrinology in the fathead minnow

Response of northern bobwhites fed single doses of gossypol

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