Finnish HLA studies confirm the increased risk conferred by HLA-B27 homozygosity in ankylosing spondylitis

Abstract

HLA-B27 homozygosity is associated with a moderately increased risk of ankylosing spondylitis compared with HLA-B27 heterozygosity. HLA-B27 positive cases had an earlier age of onset of ankylosing spondylitis than HLA-B27 negative cases and were more likely to develop AAU. HLA-DRB1 alleles may influence the age of symptom onset of ankylosing spondylitis.

Genetics in Ankylosing Spondylitis – Beyond HLA-B*27

“…This finding has been supported by the results obtained in different ethnic groups (Brown, et al, 1998a;Jaakkola, et al, 2006;Kchir, et al, 2010;Mahfoudh, et al, 2011;Ploski, et al, 1995;SaidNahal, et al, 2002;Sims, A M, et al, 2007). HLA-DRB1 was found to have a strong association with AS.…”

“…A Finnish report proposed that, in this specific population, the HLA-DRB1 alleles do not seem to play a strong role in AS susceptibility , but may influence the age of symptom onset (Jaakkola, et al, 2006). The results, in this casecontrol study, are limited due to the sample size.…”

Non-B27 MHC associations of ankylosing spondylitis

“…56 Compared with B27-negative cases, B27 carriers have previously been demonstrated to have onset of symptoms at an earlier age. 27,57,58 In the current study, there were no B27-negative cases, perhaps explaining the lack of association seen.…”

Genetic Markers in a Medieval Case of Ankylosing Spondylitis

“…This implies a risk of developing AS 3-fold higher than in heterozygous counterparts 7 . The consensus sequence obtained has shown that the individual has the HLA-B*27:90:01 subtype, for which there are no prior studies; but we may propose a possible link to AS.…”