Finite size panoramic optical system integrated design

Melatonin effect on platelets and coagulation: Implications for a prophylactic indication in COVID-19

“…Evidence suggests that following activation of the Angiotensin (Ang) II -Ang II receptor type 1 (AT1R) pathway, the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) is activated [56] , [116] , [117] , [118] , [119] . NOX is present in many different cells and organs, like cardiomyocytes, vascular smooth muscle cells, endothelial cells, macrophages, and neutrophils [120] , and its activation is one of the critical factors to the generation of reactive oxygen species (ROS) [121] . Studies have shown that COVID-19 patients experienced oxidative stress due to the activation of NOX [122] and inhibition of NOX-2 in macrophages has been reported to improve disease phenotypes by decreasing oxidative stress [123] .…”