Finite element modelling of diseased carotid bifurcations generated from in vivo computerised tomographic angiography

Creane, Arthur; Maher, Eoghan; Sultan, Sherif; Hynes, Niamh; Kelly, Daniel J.; Lally, Caitríona

doi:10.1016/j.compbiomed.2010.02.006

Cited by 35 publications

(35 citation statements)

References 29 publications

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“…In terms of other FE simulations, our results showed similar 2 or slightly lower stress values than other carotid models 8,6 . Usually the external face of the artery is a free face which does not reflect the physiological conditions of the artery, surrounded by connective tissue.…”

Section: Discussionsupporting

confidence: 63%

A Structural Approach Including the Behavior of Collagen Cross-Links to Model Patient-Specific Human Carotid Arteries

2014

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In this work the mechanical response of the carotid arterial wall is studied. Some limitations of previous models of the arterial wall are overcomed and variability of the fitting problem is reduced. We review some experimental data from the literature and provide a constitutive model to characterize such data. A strain energy function is intoduced including the behavior of cross-links between the main collagen fibers. With this function we are able to fit experimental data including information about the microstructure that previous models were not able to do. To demonstrate the applicability of the proposed model a patientspecific carotid artery geometry is reconstruted and simulated in a finite element framework, providing a microstructural description of the arterial wall. Our results qualitatively and 1 Micro-structural modeling of patient specific human carotid artery 2 quantitatively describe the experimental findings given in the literature fitting macroscopic mechanical tests including information of the microstructure distribution.

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Section: Discussionsupporting

confidence: 63%

A Structural Approach Including the Behavior of Collagen Cross-Links to Model Patient-Specific Human Carotid Arteries

2014

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“…plaque and lumen combined). This was less than 11% in all selected vessels, full details of which are provided in Creane et al (2010). In total, four vessels were selected (1-4), creating diseased and healthy models for each of them.…”

Section: Patient-specific Geometriesmentioning

confidence: 99%

“…From these images, structured hexahedral meshes of the left and right carotid bifurcations for each patient were created using a custom-built system described in Creane et al (2010). The models contained two layers, a plaque surrounded by a healthy arterial wall (Fig.…”

Section: Patient-specific Geometriesmentioning

confidence: 99%

“…It was compared to an analytical tangent to insure fast convergence. Mesh density tests were also performed, further details of which can be found in Creane et al (2010). Four patient-based models were considered in this study.…”

Section: Finite Element Implementationmentioning

confidence: 99%

“…Several studies have attempted to correlate the stresses within the plaque to its vulnerability using patient-specific finite element (FE) analyses (Li et al 2006;Tang et al 2008;Gao et al 2009;Kiousis et al 2009;Creane et al 2010). A significant limitation of many of these studies (Li et al 2006;Tang et al 2008;Gao et al 2009;Creane et al 2010) is the use of an isotropic material model given that it is known that the arterial wall behaves anisotropically (Rhodin 1980;Patel et al 1969;Holzapfel et al 2002) and since this may significantly alter the predicted stresses (Rodriguez et al 2008). The ultimate goal of many of these studies is to find a threshold stress value which will indicate plaque rupture/vulnerability.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prediction of fibre architecture and adaptation in diseased carotid bifurcations

Creane

Maher

Sultan

et al. 2010

Biomech Model Mechanobiol

Self Cite

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Many studies have used patient-specific finite element models to estimate the stress environment in atherosclerotic plaques, attempting to correlate the magnitude of stress to plaque vulnerability. In complex geometries, few studies have incorporated the anisotropic material response of arterial tissue. This paper presents a fibre remodelling algorithm to predict the fibre architecture, and thus anisotropic material response in four patient-specific models of the carotid bifurcation. The change in fibre architecture during disease progression and its affect on the stress environment in the plaque were predicted. The mean fibre directions were assumed to lie at an angle between the two positive principal strain directions. The angle and the degree of dispersion were assumed to depend on the ratio of principal strain values. Results were compared with experimental observations and other numerical studies. In non-branching regions of each model, the typical double helix arterial fibre pattern was predicted while at the bifurcation and in regions of plaque burden, more complex fibre architectures were found. The predicted change in fibre architecture in the arterial tissue during plaque progression was found to alter the stress environment in the plaque. This suggests that the specimen-specific anisotropic response of the tissue should be taken into account to accurately predict stresses in the plaque. Since determination of the fibre architecture in vivo is a difficult task, the system presented here provides a useful method of estimating the fibre architecture in complex arterial geometries.

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Patient‐specific finite element analysis of carotid artery stenting: a focus on vessel modeling

Auricchio

Conti

Ferrara

et al. 2012

Numer Methods Biomed Eng

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Finite element analysis is nowadays a well-assessed technique to investigate the impact of stenting on vessel wall and, given the rapid progression of both medical imaging techniques and computational methods, the challenge of using the simulation of carotid artery stenting as procedure planning tool to support the clinical practice can be approached. Within this context, the present study investigates the impact of carotid stent apposition on carotid artery anatomy by means of patient-specific finite element analysis. In particular, we focus on the influence of the vessel constitutive model on the prediction of carotid artery wall tensional state of lumen gain and of vessel straightening. For this purpose, we consider, for a given stent design and CA anatomy, two constitutive models for the CA wall, that is, a hyperelastic isotropic versus a fiber-reinforced hyperelastic anisotropic model. Despite both models producing similar patterns with respect to stress distribution, the anisotropic model predicts a higher vessel straightening and a more evident discontinuity of the lumen area near the stent ends as observed in the clinical practice. Although still affected by several simplifications, the present study can be considered as further step toward a realistic simulation of carotid artery stenting.

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Finite element modelling of diseased carotid bifurcations generated from in vivo computerised tomographic angiography

Cited by 35 publications

References 29 publications

A Structural Approach Including the Behavior of Collagen Cross-Links to Model Patient-Specific Human Carotid Arteries

A Structural Approach Including the Behavior of Collagen Cross-Links to Model Patient-Specific Human Carotid Arteries

Prediction of fibre architecture and adaptation in diseased carotid bifurcations

Patient‐specific finite element analysis of carotid artery stenting: a focus on vessel modeling

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