Finite-element modeling of neuromodulation via controlled delivery of potassium ions using conductive polymer-coated microelectrodes
Claudio Verardo,
Leandro Julian Mele,
Luca Selmi
et al.
Abstract:Objective. The controlled delivery of potassium is an interesting neuromodulation modality, being potassium ions involved in shaping neuron excitability, synaptic transmission, network synchronization, and playing a key role in pathological conditions like epilepsy and spreading depression. Despite many successful examples of pre-clinical devices able to influence the extracellular potassium concentration, computational frameworks capturing the corresponding impact on neuronal activity are still missing. &… Show more
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