Finite element modeling and analysis of human breast tissue for electrochemotherapy

Agoramurthy, Poornima; Campana, Luca Giovanni; Sundararajan, Raji

doi:10.1109/ceidp.2011.6232629

Cited by 6 publications

(2 citation statements)

References 7 publications

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“…21 In the last years, new designs of larger electrodes, including arrays of parallel needles or composition of triangular configurations, mounted on rigid support and used to cover larger surfaces, have been presented. [22][23][24] A different approach has been proposed in the grid electrode: the design of a prototype of grid electrode including a solution for its connection to a voltage pulse generator and the evaluation of its electroporation efficiency in a cellular model has been reported in 21. With this solution detailed in the previous study, 21 an area of some tens of cm 2 can be treated by means of a grid of equispaced needle electrodes suitably supplied in order to limit the treatment time.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Electroporation Efficiency of a Grid Electrode for Electrochemotherapy

Ongaro

Campana

Mattei

et al. 2015

Technol Cancer Res Treat

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Electrochemotherapy (ECT) is a local anticancer treatment based on the combination of chemotherapy and short, tumorpermeabilizing, voltage pulses delivered using needle electrodes or plate electrodes. The application of ECT to large skin surface tumors is time consuming due to technical limitations of currently available voltage applicators. The availability of large pulse applicators with few and more spaced needle electrodes could be useful in the clinic, since they could allow managing large and spread tumors while limiting the duration and the invasiveness of the procedure. In this article, a grid electrode with 2-cm spaced needles has been studied by means of numerical models. The electroporation efficiency has been assessed on human osteosarcoma cell line MG63 cultured in monolayer. The computational results show the distribution of the electric field in a model of the treated tissue. These results are helpful to evaluate the effect of the needle distance on the electric field distribution. Furthermore, the in vitro tests showed that the grid electrode proposed is suitable to electropore, by a single application, a cell culture covering an area of 55 cm 2 . In conclusion, our data might represent substantial improvement in ECT in order to achieve a more homogeneous and time-saving treatment, with benefits for patients with cancer.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the Electroporation Efficiency of a Grid Electrode for Electrochemotherapy

Ongaro

Campana

Mattei

et al. 2015

Technol Cancer Res Treat

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“…One possible strategy is represented by the development of large surface electrodes arrangement suitable for the application on wide areas. A possible strategy was proposed in the studies of Agoramurthy et al [28] and of Bommakanti et al [29], in which the idea of larger electrodes with respect to the standard one has been explored by means of simulations tools in order to evaluate the electric field distribution. In this case the proposed device is based on linear arrays of needles.…”

Section: Introductionmentioning

confidence: 99%

A new grid electrode for electrochemotherapy treatment of large skin tumors

Castiello

Dughiero

Scandola

et al. 2014

IEEE Trans. Dielect. Electr. Insul.

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Electrochemotherapy (ECT) is a local anticancer treatment for superficial tumors which involves the administration of a chemotherapeutic drug followed by short, high-voltage pulses. Incipient clinical experience with breast cancer patients are encouraging, with a local complete response rate ranging from 50 to 90%. However, since many patients present with multiple or widespread metastases, ECT, despite its high local antitumor efficacy, need to be applied several times in order to complete treatment delivery or maintain tumor control during the follow-up. In this paper, we propose the prototype of a new grid electrode aimed at the improvement of ECT application. The device is suitable for treating large, tumor-infiltrated skin surfaces as in breast cancer patients with chest wall metastases after mastectomy. According to our tests in different in vitro models, the new device allows to apply the voltage pulses more quickly and homogeneously when compared with standard pulse applicators. This technical advancement holds promise for improving ECT outcome and, hopefully, for sparing a number of patients from the need of multiple treatments

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Electrical resistance of human soft tissue sarcomas: an ex vivo study on surgical specimens

Campana

Cesari

Dughiero

et al. 2015

Med Biol Eng Comput

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This paper presents a study about electrical resistance, which using fixed electrode geometry could be correlated to the tissue resistivity, of different histological types of human soft tissue sarcomas measured during electroporation. The same voltage pulse sequence was applied to the tumor mass shortly after surgical resection by means of a voltage pulse generator currently used in clinical practice for electrochemotherapy that uses reversible electroporation. The voltage pulses were applied by means of a standard hexagonal electrode composed by seven, 20-mm-long equispaced needles. Irrespective of tumor size, the electrode applies electric pulses to the same volume of tissue. The resistance value was computed from the voltage and current recorded by the pulse generator, and it was correlated with the histological characteristics of the tumor tissue which was assessed by a dedicated pathologist. Some differences in resistance values, which could be correlated to a difference in tissue resistivity, were noticed according to sarcoma histotype. Lipomatous tumors (i.e., those rich in adipose tissue) displayed the highest resistance values (up to 1700 Ω), whereas in the other soft tissue sarcomas, such as those originating from muscle, nerve sheath, or fibrous tissue, the electrical resistance measured was between 40 and 110 Ω. A variability in resistance was found also within the same histotype. Among lipomatous tumors, the presence of myxoid tissue between adipocytes reduced the electrical resistance (e.g., 50-100 Ω). This work represents the first step in order to explore the difference in tissue electrical properties of STS. These results may be used to verify whether tuning electric field intensity according to the specific STS histotype could improve tissue electroporation and ultimately treatment efficacy.

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Finite element modeling and analysis of human breast tissue for electrochemotherapy

Cited by 6 publications

References 7 publications

Evaluation of the Electroporation Efficiency of a Grid Electrode for Electrochemotherapy

Evaluation of the Electroporation Efficiency of a Grid Electrode for Electrochemotherapy

A new grid electrode for electrochemotherapy treatment of large skin tumors

Electrical resistance of human soft tissue sarcomas: an ex vivo study on surgical specimens

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