Finite element analysis of nitric oxide (NO) transport in system of permeable capillary and tissue

Wei, Yajie; He, Ying; Querleux, Bernard; Mu, Lizhong

doi:10.1007/s42241-018-0076-8

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…In addition to the modeling of NO delivery in medium or large arteries, NO distribution in an ideal tubular arteriole was recently evaluated, which further considered the movements of red blood cells. The study illustrated that the permeability of red blood cells would largely determine the NO delivery process and atherosclerotic progression in microvessels [45,46]. Two computational approaches have recently been proposed to simplify the modeling of NO delivery.…”

Section: Diagnosing the Endothelial Function And Atherosclerosis Development Through Computational Modeling Of No Deliverymentioning

confidence: 99%

Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and Therapy

Zhang

Chen

et al. 2021

IJMS

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Nitric oxide (NO) is a key molecule in cardiovascular homeostasis and its abnormal delivery is highly associated with the occurrence and development of cardiovascular disease (CVD). The assessment and manipulation of NO delivery is crucial to the diagnosis and therapy of CVD, such as endothelial dysfunction, atherosclerotic progression, pulmonary hypertension, and cardiovascular manifestations of coronavirus (COVID-19). However, due to the low concentration and fast reaction characteristics of NO in the cardiovascular system, clinical applications centered on NO delivery are challenging. In this tutorial review, we first summarized the methods to estimate the in vivo NO delivery process, based on computational modeling and flow-mediated dilation, to assess endothelial function and vulnerability of atherosclerotic plaque. Then, emerging bioimaging technologies that have the potential to experimentally measure arterial NO concentration were discussed, including Raman spectroscopy and electrochemical sensors. In addition to diagnostic methods, therapies aimed at controlling NO delivery to regulate CVD were reviewed, including the NO release platform to treat endothelial dysfunction and atherosclerosis and inhaled NO therapy to treat pulmonary hypertension and COVID-19. Two potential methods to improve the effectiveness of existing NO therapy were also discussed, including the combination of NO release platform and computational modeling, and stem cell therapy, which currently remains at the laboratory stage but has clinical potential for the treatment of CVD.

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Section: Diagnosing the Endothelial Function And Atherosclerosis Development Through Computational Modeling Of No Deliverymentioning

confidence: 99%

Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and Therapy

Zhang

Chen

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Besides, the NO distribution in the idealized arterioles was evaluated with the further consideration of flowing red blood cells. The study illustrated that the permeability of red blood cells would largely determine the NO delivery process in microvessel [48,49]. However, none of the above studies have assessed the NO delivery process in the pathological artery.…”

Section: The Implication Of Nitric Oxide Delivery Analysis In Diagnosing the Endothelial Function And Atherosclerosis Developmentmentioning

confidence: 99%

The Delivery of Nitric Oxide in the Cardiovascular System: Implication for Clinical Diagnosis and Therapy

Ma¹,

Zhang²,

Chen³

et al. 2021

Preprint

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Nitric oxide (NO) is a key molecule in cardiovascular homeostasis and its abnormal delivery is highly associated with the occurrence and development of cardiovascular disease (CVD). The assessment and manipulation of NO delivery is crucial to the diagnosis and therapy of CVD, such as endothelial dysfunction, atherosclerotic progression, pulmonary hypertension, and cardiovascular manifestations of Coronavirus (COVID-19). However, due to the low concentration and fast reaction characteristics of NO in cardiovascular system, the clinical applications centered on the NO delivery are challenging. In this tutorial review, we first summarized the methods to estimate the in vivo NO delivery process based on the clinical images and mathematical modeling to assess the endothelial function and vulnerability of atherosclerotic plaque. Then, the emerging bioimaging technologies that have the potential to directly measure the arterial NO concentration were discussed, including the Raman spectroscopy and electrochemical sensor. Aside from the diagnostic methods, therapies aimed at controlling NO delivery to regulate CVD were reviewed, including the inhaled NO therapy to treat the pulmonary hypertension and COVID-19, stem cell therapy and NO-releasing platform to treat endothelial dysfunction and atherosclerosis.

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NO transport characteristics in microcirculation and its implications in the assessment of microvascular dysfunction in type 2 diabetes mellitus

He,

Liu,

Long

et al. 2024

Medicine in Novel Technology and Devices

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Finite element analysis of nitric oxide (NO) transport in system of permeable capillary and tissue

Cited by 4 publications

References 24 publications

Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and Therapy

Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and Therapy

The Delivery of Nitric Oxide in the Cardiovascular System: Implication for Clinical Diagnosis and Therapy

NO transport characteristics in microcirculation and its implications in the assessment of microvascular dysfunction in type 2 diabetes mellitus

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