In this article, a case study of a load-carrying vehicle chassis with various loading conditions in six maneuvers has been conducted. These maneuvers include acceleration and deceleration in a loaded and un-loaded situation, drops, pothole, turn, and sinusoidal obstacles. Finite element analysis has been implemented in order to calculate stress distribution and fatigue life. Stress analysis indicated that the joints stiffness is higher where the auxiliary profiles were utilized. However, this procedure is cumbersome and auxiliary plates would be a more efficient strategy. The effects of using auxiliary plates have been investigated in the fatigue and stress distribution of the aforementioned chassis. The analysis revealed that the 300 mm drop has the maximum tension and accordingly embodies the shortest fatigue life. Furthermore, for welding joints, three different strategies for geometry configuration including welding bead, reinforcing plates, and extra auxiliary profiles under the welded joints were assumed.