Finite Assembly of Three‐Dimensional DNA Hierarchical Nanoarchitectures through Orthogonal and Directional Bonding

Abstract

Reliable orthogonal bonding with precise and flexible orientation control would be ideal for building finite complex nanostructures via self‐assembly. Employing a three‐dimensional (3D) DNA origami, hexagonal prism DNA origami (HDO), as building block, we demonstrate it is practical to construct finite hierarchical nanoarchitectures with complicated conformations through orthogonal and directional bonding. The as‐designed HDO building block has twelve prescribed directional valences in 3D space and each of them supports two opposite orientations, yielding the capability to generate abundant directional bonding. Meanwhile, we minimize the thorny non‐specific interactions among HDOs and enable the orthogonal bonding between any two valences based on self‐similar designing. Consequently, various hierarchical nanostructures are prepared at will simply by the combination of HDOs with appropriate valences. We believe this route towards hierarchically assembly is inspiring and hope it will facilitate the fabrication of functional superstructures.

Rigid POSS Nanofiller Regulated the Interfacial Self‐assembly of Particles into 2D Monolayer Superlattice with Fixed Interparticle Spacing†

“…between ligands on NPs plays a decisive role for the directional assembly of NPs. [ 35‐37 ] Nie's group achieved self‐limiting self‐assembly of NPs governed by the precise control of the interaction between polymer ligands on NPs. [ 38 ] Interestingly, the assembly of NPs is chemometrics regulated; that is, NPs in assemblies acted as “artificial atom” to reproduce the structure and symmetry of molecules.…”

Automated design of 3D DNA origami with non-rasterized 2D curvature

“…DNA origami ( 1) is an enticing technique for nanoscale design because of its simple and consistent design principles (2)(3)(4)(5)(6)(7), from which it can produce self-assembling (8)(9)(10)(11)(12)(13)(14), spatially organized nanomaterials (15)(16)(17) to study nanoscale phenomena (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31). The catalog of DNA origami shapes and their respective underlying design strategies has become increasingly varied by exploitation of algorithmic principles and optimization of synthesis conditions (32)(33)(34)(35)(36).…”