Finishing Considerations for Aluminum Body Sheet Alloys

Baker, F. W.; Ginnis, M. K. Mc

doi:10.4271/740079

Cited by 2 publications

(1 citation statement)

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“…The proposed mechanism suggested that hyperglycemia may exacerbate OA progression through vascular factors, disruption of glucose metabolism or activation of pro-in ammatory mediators (cytokines, adipokines and reactive oxygen species) [52][53][54] . Moreover, cohort study and animal study have indicated that some rst-line diabetes medications, such as metformin, may have a preventive effect on OA through glucose management, inhibition of in ammation, inhibition of oxidative stress, and regulation of autophagy [55,56] . Although this effect needs further study, the risk of hyperglycemia/diabetes for OA is clear.…”

Section: Comparison With Other Studies and Possible Explanationsmentioning

confidence: 99%

Metabolic Syndrome Increases Osteoarthritis Risk : Findings from the UK Biobank Prospective Cohort Study

Zhang,

Wang,

Zhao

et al. 2023

Preprint

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Objective: The association between Metabolic Syndrome (MetS), its components, and the risk of osteoarthritis (OA) has been a topic of conflicting evidence in different studies. The aim of this present study is to investigate the association between MetS, its components, and the risk of OA using data from the UK Biobank. Methods: A prospective cohort study was conducted in the UK Biobank to assess the risk of osteoarthritis (OA) related to MetS. MetS was defined according to the criteria set by the International Diabetes Federation (IDF). Additionally, lifestyle factors, medications, and the inflammatory marker C-reactive protein (CRP) were included in the model. Cox proportional hazards regression was used to calculate hazard ratios (HR) and 95% confidence intervals (CI). The cumulative risk of OA was analyzed using Kaplan-Meier curves and log-rank tests. To explore potential nonlinear associations between MetS components and OA risk, a restricted cubic splines (RCS) model was employed. Results: A total of 45,581 cases of OA were identified among 370,311 participants, with a median follow-up time of 12.48 years. The study found that individuals with MetS had a 15% higher risk of developing OA (HR=1.15, 95%CI:1.12-1.19). Additionally, central obesity was associated with a 58% increased risk of OA (HR=1.58, 95%CI:1.5-1.66), while hyperglycemia was linked to a 13% higher risk (HR=1.13, 95%CI:1.1-1.15). Dyslipidemia, specifically in triglycerides (HR=1.07, 95%CI:1.05-1.09) and high-density lipoprotein (HR=1.05, 95%CI:1.02-1.07), was also found to be slightly associated with OA risk. Furthermore, the presence of MetS significantly increased the risk of OA by up to 35% in individuals with elevated CRP levels (HR=1.35, 95% CI:1.3-1.4). Conclusion: MetS and its components have been found to be associated with an increased risk of OA, particularly in individuals with elevated levels of CRP. These findings highlight the significance of managing MetS as a preventive and intervention measure for OA.

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Section: Comparison With Other Studies and Possible Explanationsmentioning

confidence: 99%