Fingolimod loaded niosomes attenuates sevoflurane induced cognitive impairments

Weng, Hong‑Liang; Liu, Xiaoguang; Ren, Yongying; Li, Yujian; Li, XingDa

doi:10.1007/s10544-021-00603-x

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“…Cognitive improvement using S1PR antagonists, particularly with FTY720, has been previously reported. 64 , 65 , 66 , 67 , 68 However, there has been no comprehensive evaluation of its effect on neuroinflammatory cell signaling pathways and amyloid clearance by microglia. Our previous study was based on the effect of FTY720 on neuroinflammation induced by intracranial injection of Aβ into wild type brain, but it did not use a genetic AD mouse model.…”

Section: Discussionmentioning

confidence: 99%