2012
DOI: 10.1073/pnas.1206093109
|View full text |Cite
|
Sign up to set email alerts
|

Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome

Abstract: The functional relevance of brain-derived neurotrophic factor (BDNF) is beginning to be well appreciated not only in mice, but also in humans. Because reduced levels typically correlate with impaired neuronal function, increasing BDNF levels with well-tolerated drugs diffusing into the central nervous system may help in ameliorating functional deficits. With this objective in mind, we used the sphingosine-1 phosphate receptor agonist fingolimod, a drug that crosses the blood–brain barrier. In addition, fingoli… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

17
219
4
2

Year Published

2013
2013
2021
2021

Publication Types

Select...
10

Relationship

0
10

Authors

Journals

citations
Cited by 238 publications
(242 citation statements)
references
References 45 publications
17
219
4
2
Order By: Relevance
“…28,29,45 Similarly, FTY720 treatment induced production of neurotrophic factors BDNF and GDNF, promoted NSC proliferation, and drove embryonic stem cells to differentiate into the OLG lineage. 28,[46][47][48] Furthermore, it has also been shown that FTY720 can enhance remyelination in organotypic slice cultures. 27,49,50 In vivo studies demonstrated that FTY720 is effective at treating acute EAE by promoting OPC proliferation and differentiation and by stimulating the sonic hedgehog (Shh) signaling pathway.…”
Section: Discussionmentioning
confidence: 99%
“…28,29,45 Similarly, FTY720 treatment induced production of neurotrophic factors BDNF and GDNF, promoted NSC proliferation, and drove embryonic stem cells to differentiate into the OLG lineage. 28,[46][47][48] Furthermore, it has also been shown that FTY720 can enhance remyelination in organotypic slice cultures. 27,49,50 In vivo studies demonstrated that FTY720 is effective at treating acute EAE by promoting OPC proliferation and differentiation and by stimulating the sonic hedgehog (Shh) signaling pathway.…”
Section: Discussionmentioning
confidence: 99%
“…S1PRs have also been shown to limit events of demyelination and promote remyelination, which are probably mediated by the dampening of pro-inflammatory cytokine levels (Miron et al, 2010;Sheridan and Dev, 2012). Overall, therefore, S1PRs represent an important drug target that can be exploited for use in neuroinflammatory, demyelinating and neurodegenerative diseases, as documented by a growing body of literature (Asle-Rousta et al, 2013;Deogracias et al, 2012). Here we investigate whether regulation of S1P signalling alters psychosine-induced astrocyte dysfunction, pro-inflammatory cytokine release and demyelination.…”
Section: Introductionmentioning
confidence: 99%
“…As previously reported, this epigenetic regulation by fingolimod could also lead to an augmented expression of growth factors such as BDNF that play a fundamental role in synaptic plasticity process, which are involved in memory formation and retention [21,[80][81][82]. In any case, the role of HDAC modulation in epilepsy and more specifically in WAG/Rij rats still does not permit us to either support or discard its involvement in fingolimod effects, also considering the potential of HDAC modulation in epileptogenesis and animal behavior [34,83,84].…”
Section: Discussionmentioning
confidence: 80%