Finger Length Pattern as a Biomarker for Osteoarthritis and Chronic Joint Pain: A Population‐Based Study and Meta‐Analysis After Systematic Review

Kruijf, Marjolein de; Kerkhof, Hanneke J. M.; Peters, Marjolein J.; Bierma-Zeinstra, Sita M A; Hofman, Albert; Uitterlinden, André G.; Huggen, Frank J. P. M.; Meurs, Joyce B. J. van

doi:10.1002/acr.22320

Cited by 10 publications

(16 citation statements)

References 25 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Type 3 finger length pattern, an indicator of prenatal androgen exposure, was associated with symptomatic (but not radiographic) knee OA, chronic pain, and hand OA in the Rotterdam Study (21). Almost half of the association between elevated BMI and knee OA was explained by serum leptin level in the Maintenance of Balance, Independent Living, Intellect, and Zest in the Elderly Boston Study (22).…”

Section: Resultsmentioning

confidence: 99%

Osteoarthritis year in review 2015: clinical

Sharma

2016

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

The purpose of this review is to highlight clinical research in osteoarthritis. A literature search was conducted using PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) with the search terms “osteoarthritis [All Fields] AND treatment [All Fields]” and the following limits activated: humans, English language, all adult 19+ years, published between April 1, 2014 and April 1, 2015. A second literature search was then conducted with the search terms “osteoarthritis [All Fields] AND epidemiology [All Fields]”, with the same limits. Reports of surgical outcome, case series, surgical technique, tissue sample or culture studies, trial protocols, and pilot studies were excluded. Of 1523, 148 were considered relevant. Among epidemiologic and observational clinical studies, themes included physical activity, early knee OA, and confidence/instability/falls. Symptom outcomes of pharmacologic treatments were reported for methotrexate, adalimumab, anti-nerve growth factor monoclonal antibodies, strontium ranelate, bisphosphonates, glucosamine, and chondroitin sulfate, and structural outcomes of pharmacologic treatments for strontium ranelate, recombinant human fibroblast growth factor 18, and glucosamine and chondroitin sulfate. Symptom outcomes of non-pharmacologic interventions were reported for: neuromuscular exercise, quadriceps strengthening, weight reduction and maintenance, TENS, therapeutic ultrasound, stepped care strategies, cognitive behavior therapy for sleep disturbance, acupuncture, gait modification, booster physical therapy, a web-based therapeutic exercise resource center for knee OA; hip physical therapy for hip OA; and joint protection and hand exercises for hand OA. Structure outcomes of non-pharmacologic interventions were reported for patellofemoral bracing.

show abstract

Section: Resultsmentioning

confidence: 99%

Osteoarthritis year in review 2015: clinical

Sharma

2016

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

show abstract

“…We have identified several factors associated to pain, which were not related to structural damage of the joints [ 200 ]. We demonstrated that type 3 finger length pattern, an indicator of prenatal androgen exposure, was associated with having symptomatic knee OA, and chronic pain [ 201 ].…”

Section: Endocrine and Locomotor Diseasesmentioning

confidence: 99%

The Rotterdam Study: 2016 objectives and design update

et al. 2015

Self Cite

View full text Add to dashboard Cite

The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. The findings of the Rotterdam Study have been presented in over 1200 research articles and reports (see www.erasmus-epidemiology.nl/rotterdamstudy). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods.

show abstract

“…Another example is finger length pattern, which is thought to be an indicator of prenatal androgen exposure. Type 3 finger length pattern (longer fourth digit than second digit) has been associated with having symptomatic knee OA and chronic pain, which might be explained by an influence of embryogenic sex hormone exposure on brain development …”

Section: Epigenetic Programming During Developmentmentioning

confidence: 99%

Role of Epigenomics in Bone and Cartilage Disease

Meurs

Boer

López-Delgado

et al. 2019

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

Phenotypic variation in skeletal traits and diseases is the product of genetic and environmental factors. Epigenetic mechanisms include information-containing factors, other than DNA sequence, that cause stable changes in gene expression and are maintained during cell divisions. They represent a link between environmental influences, genome features, and the resulting phenotype. The main epigenetic factors are DNA methylation, posttranslational changes of histones, and higher-order chromatin structure. Sometimes non-coding RNAs, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are also included in the broad term of epigenetic factors. There is rapidly expanding experimental evidence for a role of epigenetic factors in the differentiation of bone cells and the pathogenesis of skeletal disorders, such as osteoporosis and osteoarthritis. However, different from genetic factors, epigenetic signatures are cell-and tissue-specific and can change with time. Thus, elucidating their role has particular difficulties, especially in human studies. Nevertheless, epigenomewide association studies are beginning to disclose some disease-specific patterns that help to understand skeletal cell biology and may lead to development of new epigenetic-based biomarkers, as well as new drug targets useful for treating diffuse and localized disorders. Here we provide an overview and update of recent advances on the role of epigenomics in bone and cartilage diseases.Besides chromatin-related marks and structure, non-coding RNAs (ncRNAs) are also frequently included among the mechanisms of epigenetic control. (8) They are classified as small RNAs (<200 nucleotides) and long RNAs (>200 nucleotides). The best-known subset of small RNAs are microRNAs (miRNAs, 18 to 25 nucleotides), which inhibit protein synthesis by binding to the 3 0 -untranslated region of target mRNAs. Long non-coding RNAs (lncRNAs) modulate the activity of both nearby genes and distant genes by a variety of mechanisms. For instance, they often serve as scaffolds for transcription factors and other molecules involved in initiation of transcription, including Box 1. Epigenomics-Related TermsChromatin: The complex of DNA and its packaging molecules. The core of the chromatin is the nucleosome, which consists of an octamer of 4 histones around which 147 bp of DNA is wrapped around.Chromosome conformation capture and Hi-C: Techniques used to map the spatial (3D) organization of the chromatin in the nucleus. Chromosome conformation capture (3C) quantifies the number of interactions between a given loci and the rest of the genome. In Hi-C, all genomic interaction between all genomic regions are quantified.CTCF: CCCTC-binding factor, highly conserved zinc finger protein involved in diverse genomic regulatory functions, including transcriptional activation/repression, insulation, imprinting, and X-chromosome inactivation, through mediating the formation of chromatin loops. DNA methyl-transferases (DNMTs): Family of enzymes responsible for the methylation of DNA. DNMT1...

show abstract

Finger Length Pattern as a Biomarker for Osteoarthritis and Chronic Joint Pain: A Population‐Based Study and Meta‐Analysis After Systematic Review

Cited by 10 publications

References 25 publications

Osteoarthritis year in review 2015: clinical

Osteoarthritis year in review 2015: clinical

The Rotterdam Study: 2016 objectives and design update

Role of Epigenomics in Bone and Cartilage Disease

Contact Info

Product

Resources

About