Fine-Tuning Development Through Antagonistic Peptides: An Emerging Theme

Lee, Jin Suk; Smet, Ive De

doi:10.1016/j.tplants.2016.10.003

Cited by 11 publications

(9 citation statements)

References 12 publications

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“…The CEP family members displayed distinct expression patterns in Arabidopsis development and were expressed divergently and exhibited tissue-specific expression patterns in Oryza sativa (Delay et al 2013;Sui et al 2016). However, the biological functions for most CEPs remain largely unknown (Lee and De Smet 2016;Okamoto et al 2016). In this study, twenty-seven CEP genes that contained the conserved CEP peptide domain were identified in apple.…”

Section: Discussionmentioning

confidence: 96%

Identification and expression of the CEP gene family in apple (Malus×domestica)

You

et al. 2018

Journal of Integrative Agriculture

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Plant peptide hormones play important roles in plant growth and development. Among these hormones, the C-TERMI-NALLYENCODED PEPTIDE (CEP) belongs to a newly found peptide family that regulates root development in Arabidopsis as well as in other species. However, nothing is known about the CEP genes in apple (Malus×domestica, MdCEP). In this study, a total of 27 apple CEP genes were identified through a genome-wide analysis and were phylogenetically divided into three classes (I, II and III). The predicted MdCEP genes were distributed across 10 of 17 chromosomes with different densities. Next, the gene structures and motif compositions of the MdCEP genes were analyzed. Subsequently, the expression analysis suggested that the MdCEP genes were highly activated in roots and that MdCEP23 may play an important role in regulating the growth and development of roots. Moreover, all of the MdCEP genes were responsive to multiple abiotic stresses, indicating that MdCEP genes may be involved with various aspects of physiological processes in apple. Nearly one-third of MdCEP genes had a significant response to low nitrogen treatment. Most of the MdCEP genes were up-regulated under stress, including mannitol, polyethylene glycol (PEG) and abscisic acid (ABA), suggesting that MdCEP genes may be involved in the drought stress response. This study provides insight into the putative functions of the MdCEP genes using a genome-wide analysis of the CEP gene family.

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Section: Discussionmentioning

confidence: 96%

Identification and expression of the CEP gene family in apple (Malus×domestica)

You

et al. 2018

Journal of Integrative Agriculture

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“…This is consistent with a model where CEP5 along with the other sucrose-induced CEP genes produce ligands, that act as agonists of CEPR1 activity and thereby inhibit the extent of sucrose-dependent LR growth. A potential role, however, for CEP5 as an antagonist of CEPR1 function in the regulation of LR initiation has also been proposed based on a CEP5 knockdown line and a CEPR1 point mutant xip1-1 displaying opposite phenotypes (Lee and De Smet, 2016; Roberts et al , 2016).…”

Section: Discussionmentioning

confidence: 99%

CEP–CEPR1 signalling inhibits the sucrose-dependent enhancement of lateral root growth

Chapman

Taleski

Ogilvie

et al. 2019

Journal of Experimental Botany

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Lateral root (LR) proliferation is a major determinant of soil nutrient uptake. How resource allocation controls the extent of LR growth remains unresolved. We used genetic, physiological, transcriptomic, and grafting approaches to define a role for C-TERMINALLY ENCODED PEPTIDE RECEPTOR 1 (CEPR1) in controlling sucrose-dependent LR growth. CEPR1 inhibited LR growth in response to applied sucrose, other metabolizable sugars, and elevated light intensity. Pathways through CEPR1 restricted LR growth by reducing LR meristem size and the length of mature LR cells. RNA-sequencing of wild-type (WT) and cepr1-1 roots with or without sucrose treatment revealed an intersection of CEP–CEPR1 signalling with the sucrose transcriptional response. Sucrose up-regulated several CEP genes, supporting a specific role for CEP–CEPR1 in the response to sucrose. Moreover, genes with basally perturbed expression in cepr1-1 overlap with WT sucrose-responsive genes significantly. We found that exogenous CEP inhibited LR growth via CEPR1 by reducing LR meristem size and mature cell length. This result is consistent with CEP–CEPR1 acting to curtail the extent of sucrose-dependent LR growth. Reciprocal grafting indicates that LR growth inhibition requires CEPR1 in both the roots and shoots. Our results reveal a new role for CEP–CEPR1 signalling in controlling LR growth in response to sucrose.

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“…The EPF-family of secreted cysteine-rich peptides regulates multiple aspects of stomatal development and other developmental processes through the ERECTA-family receptors (Torii, 2012; Lee and De Smet, 2016). In this study, we discovered an unexpected role for EPF1 and ERL1 in the autocrine regulation of stomatal differentiation potential.…”

Section: Discussionmentioning

confidence: 99%

Autocrine regulation of stomatal differentiation potential by EPF1 and ERECTA-LIKE1 ligand-receptor signaling

Han

Dang

et al. 2017

eLife

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Development of stomata, valves on the plant epidermis for optimal gas exchange and water control, is fine-tuned by multiple signaling peptides with unique, overlapping, or antagonistic activities. EPIDERMAL PATTERNING FACTOR1 (EPF1) is a founding member of the secreted peptide ligands enforcing stomatal patterning. Yet, its exact role remains unclear. Here, we report that EPF1 and its primary receptor ERECTA-LIKE1 (ERL1) target MUTE, a transcription factor specifying the proliferation-to-differentiation switch within the stomatal cell lineages. In turn, MUTE directly induces ERL1. The absolute co-expression of ERL1 and MUTE, with the co-presence of EPF1, triggers autocrine inhibition of stomatal fate. During normal stomatal development, this autocrine inhibition prevents extra symmetric divisions of stomatal precursors likely owing to excessive MUTE activity. Our study reveals the unexpected role of self-inhibition as a mechanism for ensuring proper stomatal development and suggests an intricate signal buffering mechanism underlying plant tissue patterning.DOI: http://dx.doi.org/10.7554/eLife.24102.001

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Fine-Tuning Development Through Antagonistic Peptides: An Emerging Theme

Cited by 11 publications

References 12 publications

Identification and expression of the CEP gene family in apple (Malus×domestica)

Identification and expression of the CEP gene family in apple (Malus×domestica)

CEP–CEPR1 signalling inhibits the sucrose-dependent enhancement of lateral root growth

Autocrine regulation of stomatal differentiation potential by EPF1 and ERECTA-LIKE1 ligand-receptor signaling

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