Fine structure of trabecular meshwork and iris in pigmentary glaucoma

Shimizu, Tsutomu; Hara, Katsunori; Futa, R

doi:10.1007/bf00413148

Cited by 19 publications

(12 citation statements)

References 7 publications

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“…The full circumference of the TM tends to be affected, although pigmentation is more prominent inferiorly, possibly owing to gravity. Histologically, the melanin is located within the TM cells indicative of their phagocytic properties 15,22,35,44,45,51–54 …”

Section: Pigment Dispersion Syndromementioning

confidence: 99%

“…Histologically, the melanin is located within the TM cells indicative of their phagocytic properties. 15,22,35,44,45,[51][52][53][54] Pigment deposition also occurs at Schwalbe's line, 4 producing a thin, dark line similar to Sampaolesi's line in PXF syndrome. In a similar manner to the TM, Schwalbe's line tends to be more prominently pigmented inferiorly.…”

Section: Backward Bowing Of the Irismentioning

confidence: 99%

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Pigment dispersion syndrome and pigmentary glaucoma – a major review

Niyadurupola

Broadway

2008

Clinical Exper Ophthalmology

161

167

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Pigment dispersion syndrome (PDS) is an interesting condition that can lead to secondary open angle glaucoma. Pigmentary glaucoma is primarily a disease of young people, myopes and men. PDS is characterized by the presence of Krukenberg spindles, iris trans-illumination defects, trabecular meshwork pigmentation and backward bowing of the iris. Posterior bowing of the iris causes rubbing of the pigmented iris epithelium against lens structures, liberation of pigment and trabecular meshwork changes that result in reduced aqueous outflow with the risk of glaucoma. Peripheral laser iridotomy can reverse backward bowing of the iris and may prevent progression of pigmentary glaucoma.

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Section: Pigment Dispersion Syndromementioning

confidence: 99%

Section: Backward Bowing Of the Irismentioning

confidence: 99%

Pigment dispersion syndrome and pigmentary glaucoma – a major review

Niyadurupola

Broadway

2008

Clinical Exper Ophthalmology

161

167

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“…The separation between beams observed in controls was not readily visualized in participants with PDS (see also Ref. 33).…”

Section: Discussionmentioning

confidence: 98%

High-Resolution, Adaptive Optics Imaging of the Human Trabecular Meshwork In Vivo

King

Burns

Sapoznik

et al. 2019

Trans. Vis. Sci. Tech.

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PurposeTo image the human trabecular meshwork (TM) in vivo using adaptive optics gonioscopy (AOG) with approximately 2-μm lateral resolution.MethodsAn existing Indiana University adaptive optics scanning laser ophthalmoscope was altered by adding a 12-mm button lens to a clinical gonioscopic lens allowing high-resolution imaging of the human iridocorneal angle. First an anatomic model eye was used to refine the imaging technique and then nine participants (7 controls and 2 participants with pigment dispersion syndrome) were imaged.ResultsAll nine participants were successfully imaged without adverse events. High-resolution imaging of the human TM was achieved allowing for visualization of the TM beams, and presumed endothelial cells. Uveal meshwork beams in controls averaged 25.5 μm (range, 15.2–44.7) in diameter with pores averaging 42.6 μm (range, 22.3–51.4) while the corneoscleral meshwork pores averaged 8.9 μm (range, 7.7–12.1). Differences in appearance of the uveal and corneoscleral meshwork were noted between the two participants with pigment dispersion syndrome and the controls. These included nearly absent spacing between the beams and enlarged endothelial cells with hyperreflective areas.ConclusionsAOG allows for near cellular level resolution of the human TM in vivo. This may allow for further understanding of age-related changes that occur as well as provide a deeper understanding of medical and surgical alterations for the treatment of glaucoma.Translational RelevanceFurther development of this approach may allow for direct measurements at a micometer level in vivo of changes that occur in the human trabecular meshwork with glaucoma and therapeutic interventions.

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“…Histologic examination has revealed that pigment granules are phagocytosed by both corneal epithelial cells and trabecular meshwork cells rather than being adsorbed onto their surface [ 11 – 14 ]. Phagocytic stress causes alterations to the trabecular meshwork extracellular matrix structure and adhesion [ 15 , 16 ] which could explain the trabecular meshwork dysfunction observed in PDS/PG patients [ 14 ]. In PDS/PG patients, trabecular meshwork cells die and exhibit localized necrosis [ 17 ].…”

Section: Pathophysiologymentioning

confidence: 99%

Molecular Genetics of Pigment Dispersion Syndrome and Pigmentary Glaucoma: New Insights into Mechanisms

Lahola-Chomiak

Walter

2018

Journal of Ophthalmology

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We explore the ideas and advances surrounding the genetic basis of pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG). As PG is the leading cause of nontraumatic blindness in young adults and current tailored interventions have proven ineffective, a better understanding of the underlying causes of PDS, PG, and their relationship is essential. Despite PDS being a subclinical disease, a large proportion of patients progress to PG with associated vision loss. Decades of research have supported a genetic component both for PDS and conversion to PG. We review the body of evidence supporting a genetic basis in humans and animal models and reevaluate classical mechanisms of PDS/PG considering this new evidence.

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Fine structure of trabecular meshwork and iris in pigmentary glaucoma

Cited by 19 publications

References 7 publications

Pigment dispersion syndrome and pigmentary glaucoma – a major review

Pigment dispersion syndrome and pigmentary glaucoma – a major review

High-Resolution, Adaptive Optics Imaging of the Human Trabecular Meshwork In Vivo

Molecular Genetics of Pigment Dispersion Syndrome and Pigmentary Glaucoma: New Insights into Mechanisms

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